Outer mitochondrial membrane

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The outer mitochondrial membrane, which encloses the entire organelle, has a protein-to-phospholipid ratio similar to the eukaryotic plasma membrane (about 1:1 by weight). It contains numerous integral proteins called porins, which contain a relatively large internal channel (about 2-3 nm) that is permeable to all molecules of 5000 daltons or less. Larger molecules can only traverse the outer membrane by active transport through mitochondrial membrane transport proteins. The outer membrane also contains enzymes involved in such diverse activities as the elongation of fatty acids, oxidation of epinephrine (adrenaline), and the degradation of tryptophan.

v • d • e Mitochondrial enzymes and transporters
Outer membrane	Long fatty acyl CoA synthetase - Kynureninase - Monoamine oxidase
Intermembrane space	Adenylate kinase - Creatine kinase
Inner membrane	Coenzyme Q - cytochrome c reductase -Cytochrome c - Dihydroorotate dehydrogenase -Glutamate aspartate transporter - Glycerol-3-phosphate dehydrogenase - NADH dehydrogenase - Succinate dehydrogenase
Matrix	Aconitase - Aspartate transaminase - ALDH2 - Carbamoyl phosphate synthase - Citrate synthase - Fumarase - Glutamate dehydrogenase - Isocitrate dehydrogenase - Malate dehydrogenase - Ornithine transcarbamoylase - Oxoglutarate dehydrogenase - Pyruvate dehydrogenase complex - Succinyl coenzyme A synthetase
Mitochondrial DNA	Complex I (7 units) - Complex III (1 unit) - Complex IV (3 units) - ATP synthase (2 units)

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Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .