11β-hydroxysteroid dehydrogenase type 1

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hydroxysteroid (11-beta) dehydrogenase 1
Identifiers
SymbolHSD11B1
Alt. symbolsHSD11B, HSD11
Entrez3290
HUGO5208
OMIM600713
RefSeqNM_005525
UniProtP28845
Other data
EC number1.1.1.146
LocusChr. 1 q32-q41

11β-hydroxysteroid dehydrogenase type 1 is an NADPH-dependent enzyme highly expressed in key metabolic tissues including liver, adipose tissue, and the central nervous system.

In these tissues, HSD11B1 reduces cortisone to the active hormone cortisol that activates glucocorticoid receptors.

It is inhibited by carbenoxolone, a drug typically used in the treatment of peptic ulcers.


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