Alpha 1-antichymotrypsin
| serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
| |
| Identifiers | |
| Symbol | SERPINA3 |
| Alt. Symbols | AACT |
| Entrez | 12 |
| HUGO | 16 |
| OMIM | 107280 |
| RefSeq | NM_001085 |
| UniProt | P01011 |
| Other data | |
| Locus | Chr. 14 q32.1 |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Alpha 1-antichymotrypsin is an alpha globulin glycoprotein that is a member of the serine proteinase inhibitor (serpin) family.
It inhibits the activity of certain enzymes called proteinases, such as cathepsin G that is found in neutrophils, and chymases found in mast cells, by cleaving them into a different shape or conformation. This activity protects some tissues, such as the lower respiratory tract, from damage caused by proteolytic enzymes.[1]
Alpha 1-antichymotrypsin is also associated with the pathogenesis of Alzheimer's disease as it enhances the formation of amyloid-fibrils in this disease.[1]
This enzyme is produced in the liver, and is an acute phase protein that is induced during inflammation.
References
- ↑ 1.0 1.1 Kalsheker N (1996). "Alpha 1-antichymotrypsin". Int. J. Biochem. Cell Biol. 28 (9): 961-4. PMID 8930118.
External links
Serpins | |
|---|---|
| inhibitory | Alpha 1-antichymotrypsin - Alpha 1-antitrypsin - Alpha 2-antiplasmin - Antithrombin - C1-inhibitor - Heparin cofactor II - Protein C inhibitor - Plasminogen activator inhibitor-1 - Plasminogen activator inhibitor-2 - Protein Z-related protease inhibitor |
| noninhibitory | Maspin - Ovalbumin - Heat shock protein 47 - Thyroxine-binding globulin - Transcortin |
Globulins: alpha globulins |
|---|
| Alpha 1-antichymotrypsin - Alpha 1-antitrypsin - Alpha 2-macroglobulin - Alpha 2-antiplasmin - Antithrombin - Ceruloplasmin - Haptoglobin - Heparin cofactor II - Orosomucoid - Retinol binding protein - Transcortin |
Protein: glycoproteins |
|---|
| Activin - ADAM protein - Alpha 1-antichymotrypsin - Apolipoprotein H - CD70 - Asialoglycoprotein - Avidin - B-cell activating factor - 4-1BB ligand - Cholesterylester transfer protein - Clusterin - Colony-stimulating factor - Haemopexin - Inhibin - Lactoferrin - Membrane glycoproteins - Mucoprotein - Myelin protein zero - Osteonectin - Protein C - Protein S - Proteoglycan - Serum Amyloid P component - Sialoglycoprotein (CD43, Glycophorin, Glycophorin C) - Thrombopoietin - Thyroglobulin - Thyroxine-binding proteins - Transcortin - Tumor necrosis factor-alpha - Uteroglobin - Vitronectin |
Acute phase proteins |
|---|
| Alpha 1-antichymotrypsin - Alpha 1-antitrypsin - Alpha 2-macroglobulin - C-reactive protein - Ceruloplasmin - C3 - Fibrin - Haptoglobin - Haemopexin - Orosomucoid - Serum albumin (negative) - Amyloid (P, A) - Transferrin |
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