Plasminogen activator inhibitor-2
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| serpin peptidase inhibitor, clade B (ovalbumin), member 2
| |
| Identifiers | |
| Symbol | SERPINB2 |
| Alt. Symbols | PLANH2, PAI2 |
| Entrez | 5055 |
| HUGO | 8584 |
| OMIM | 173390 |
| RefSeq | NM_002575 |
| UniProt | P05120 |
| Other data | |
| Locus | Chr. 18 q21.3 |
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Plasminogen activator inhibitor-2 (placental PAI) is a coagulation factor which inactivates tPA & urokinase. It is present in most cells, especially monocytes/macrophages. PAI-2 exists in two forms, a 60 kDa extracellular glycosylated form and a 43 kDa intracellular form.
It is only present at detectable quantities in blood during pregnancy, as it is produced by the placenta, and may explain partially the increased rate of thrombosis during pregnancy. The majority of expressed PAI-2 remains unsecreted due to the presence of an inefficient internal signal peptide.
See also
External links
Proteins: coagulation | |
|---|---|
| Coagulation factors | intrinsic pathway (FXII, FXI, FIX, FVIII) - extrinsic pathway (Tissue factor, FVII) - common pathway (FX, FV, (Pro)thrombin / FII, Fibrin / FI, FXIII) - HMWK - vWF - Kallikrein |
| Inhibitors | Antithrombin - Protein C - Protein S - Protein Z - ZPI - TFPI |
| Fibrinolysis | Plasmin - tPA/urokinase - PAI-1/2 - α2-AP - α2-macroglobulin - TAFI |
Serpins | |
|---|---|
| inhibitory | Alpha 1-antichymotrypsin - Alpha 1-antitrypsin - Alpha 2-antiplasmin - Antithrombin - C1-inhibitor - Heparin cofactor II - Protein C inhibitor - Plasminogen activator inhibitor-1 - Plasminogen activator inhibitor-2 - Protein Z-related protease inhibitor |
| noninhibitory | Maspin - Ovalbumin - Heat shock protein 47 - Thyroxine-binding globulin - Transcortin |
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
