Sandbox chemo1: Difference between revisions

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== Chemotherapeutic Agents by Category ==
== Chemotherapeutic Agents by Category ==


=== Cytotoxic Chemotherapy ===
=== Alkylating agents ===
 
==== Alkylating agents ====


====== Nitrogen mustards ======
====== Nitrogen mustards ======
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* [[Thiotepa|Thiotepa (Tepadina)]]
* [[Thiotepa|Thiotepa (Tepadina)]]


====== Methylhydrazine derivative ======
====== Methylhydrazines ======
* [[Procarbazine|Procarbazine (Matulane)]]
* [[Procarbazine|Procarbazine (Matulane)]]


====== Alkyl sulfonate ======
====== Alkylsulfonates ======
* [[Busulfan|Busulfan (Myleran)]]
* [[Busulfan|Busulfan (Myleran)]]


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----
----


===== Anthracyclines =====
=== Antimetabolites ===
*[[Daunorubicin|Daunorubicin (Daunoxome)]]
 
*[[Doxorubicin|Doxorubicin (Adriamycin,Rubex)]]
====== Folic acid analogs ======
*[[Epirubicin|Epirubicin (Ellence)]]
* [[Methotrexate|Methotrexate (Mexate, Folex)]]
*[[Idarubicin hydrochloride|Idarubicin (Idamycin)]]
* [[Pemetrexed|Pemetrexed (Alimta)]]
 
====== Pyrimidine analogs ======
* [[Azacytidine|Azacytidine (Vidaza)]]
* [[Capecitabine|Capecitabine (Xeloda)]]
* [[Cytarabine|Cytarabine (Cytosar)]]
* [[Floxuridine|Floxuridine (FUDR)]]
* [[Fluorouracil|Fluorouracil (Adrucil, Efudex)]]
* [[Gemcitabine|Gemcitabine (Gemzar)]]


====== Purine analogs ======
* [[Cladribine|Cladribine (Leustatin)]]
* [[Clofarabine|Clofarabine (Clolar)]]
* [[Fludarabine|Fludarabine (Fludara)]]
* [[Mercaptopurine|Mercaptopurine (Purinethol)]]
* [[Nelarabine|Nelarabine (Arranon)]]
* [[Pentostatin|Pentostatin (Nipent)]]
* [[Thioguanine|Thioguanine (Tabloid)]]


===== Antimetabolites =====
====== Ribonucleotide reductase inhibitors ======
*[[Capecitabine|Capecitabine (Xeloda)]]
* [[Hydroxyurea|Hydroxyurea (Hydrea)]]
*[[Fluorouracil|Fluorouracil (Adrucil, Efudex)]]
*[[Floxuridine|Floxuridine (FUDR)]]
*[[Fludarabine|Fludarabine (Fludara)]]
*[[Gemcitabine|Gemcitabine (Gemzar)]]
*[[Hydroxyurea|Hydroxyurea (Hydrea)]]
*[[Mercaptopurine|Mercaptopurine (Purinethol)]]
*[[Methotrexate|Methotrexate (Mexate,Folex)]]


===== Antimitotic agent=====
----
*[[Docetaxel|Docetaxel (Taxotere)]]
*[[Eribulin|Eribulin (Halaven)]]
*[[Etoposide|Etoposide (Vespid)]]
*[[Ixabepilone|Ixabepilone (Ixempra)]]
*[[Vinblastine|Vinblastine (Velban,Velsar)]]
*[[Vincristine|Vincristine (Oncovin,Vincasar)]]
*[[Vinorelbine|Vinorelbine (Navelbine)]]


=== Natural products ===


===== DNA synthesis inhibitors =====
====== Vinca alkaloids ======
*[[Streptozocin|Streptozocin (Zanosar)]]
* [[Vinblastine|Vinblastine (Velban, Velsar)]]
* [[Vincristine|Vincristine (Oncovin, Vincasar)]]
* [[Vincristine liposome|Vincristine liposome (Marqibo)]]
* [[Vinorelbine|Vinorelbine (Navelbine)]]


===== Microtubule inhibitors =====
====== Taxanes ======
*[[Ixabepilone|Ixabepilone (Ixempra)]]
* [[Docetaxel|Docetaxel (Taxotere)]]
* [[Paclitaxel|Paclitaxel (Taxol, Onxol)]]


===== Nitrogen mustards =====
====== Epipodophyllotoxins ======
*[[Estramustine|Estramustine (Emcyt)]]
* [[Etoposide|Etoposide (Vespid)]]
*[[Mechlorethamine|Mechlorethamine (Mustargen)]]
* [[Teniposide|Teniposide (Vumon)]]


===== Nitrosureas =====
====== Camptothecins ======
*[[Lomustine|Lomustine (CeeNU)]]
* [[Irinotecan|Irinotecan (Camptosar)]]
* [[Topotecan|Topotecan (Hycamtin)]]


===== Platinum agents =====
====== Anthracyclines ======
* [[Bleomycin|Bleomycin (Blenoxane)]]
* [[Dactinomycin|Dactinomycin (Cosmegen)]]
* [[Daunorubicin|Daunorubicin (Daunoxome)]]
* [[Doxorubicin|Doxorubicin (Adriamycin, Rubex)]]
* [[Epirubicin|Epirubicin (Ellence)]]
* [[Idarubicin|Idarubicin (Idamycin)]]
* [[Mitomycin C|Mitomycin C (Mutamycin)]]
* [[Mitoxantrone|Mitoxantrone (Novantrone)]]
* [[Valrubicin|Valrubicin (Valstar)]]


===== Proteasome inhibitors =====
====== Antineoplastic enzymes ======
*[[Carfilzomib|Carfilzomib (Kyprolis)]]
* [[L-Asparaginase|L-Asparaginase (Elspar)]]
* [[Pegaspargase|Pegaspargase (Oncaspar)]]
* [[Glucarpidase|Glucarpidase (Voraxaze)]]
 
----
 
=== Hormones and Antagonists ===


===== Taxanes =====
====== Adrenocortical suppressants ======
* [[Mitotane|Mitotane (Lysodren)]]


===== Topoisomerase inhibitors =====
====== Adrenocortico-steroids ======
*[[Irinotecan hydrochloride|Irinotecan (Camptosar)]]
* [[Prednisone|Prednisone (Deltasone)]]


===== Vinca alkaloids =====
====== Progestins ======
*[[Vinblastine|Vinblastine (Velban,Velsar)]]
* [[Medroxyprogesterone|Medroxyprogesterone (Provera)]]
*[[Vincristine|Vincristine (Oncovin,Vincasar)]]
* [[Megestrol|Megestrol (Megace)]]


====== Anti-estrogens ======
* [[Tamoxifen|Tamoxifen (Nolvadex)]]
* [[Toremifene|Toremifene (Fareston)]]


----
====== Aromatase inhibitors ======
* [[Anastrozole|Anastrozole (Arimidex)]]
* [[Exemestane|Exemestane (Aromasin)]]
* [[Letrozole|Letrozole (Femara)]]


{{Button|Endocrine therapy}}
====== Androgens ======
* [[Fluoxymesterone|Fluoxymesterone (Halotestin)]]


===== Antiandrogens =====
====== Anti-androgens ======
* [[Abiraterone|Abiraterone (Zytiga)]]
* [[Abiraterone|Abiraterone (Zytiga)]]
* [[Bicalutamide|Bicalutamide (Casodex)]]
* [[Bicalutamide|Bicalutamide (Casodex)]]
* [[Dutasteride|Dutasteride (Avodart)]]
* [[Dutasteride|Dutasteride (Avodart)]]
* [[Enzalutamide|Enzalutamide (Xtandi)]]
* [[Enzalutamide|Enzalutamide (Xtandi)]]
* [[Flutamide|Flutamide (Eulexin)]]
* [[Finasteride|Finasteride (Proscar)]]
* [[Finasteride|Finasteride (Proscar)]]
* [[Flutamide|Flutamide (Eulexin)]]
* [[Ketoconazole|Ketoconazole (Nizoral)]]
* [[Ketoconazole|Ketoconazole (Nizoral)]]
* [[Leuprolide|Leuprolide (Lupron)]]
* [[Nilutamide|Nilutamide (Nilandron)]]
* [[Nilutamide|Nilutamide (Nilandron)]]
* [[Triptorelin|Triptorelin (Trelstar)]]
* [[Triptorelin|Triptorelin (Trelstar)]]


===== Steroid synthesis inhibitors =====
===== GnRH agonists =====
* [[Abiraterone|Abiraterone (Zytiga)]]
* [[Buserelin|Buserelin (Superfact)]]  
* [[Aminoglutethimide|Aminoglutethimide (Cytadren)]]
* [[Goserelin|Goserelin (Zoladex)]]
* [[Anastrozole|Anastrozole (Arimidex)]]
* [[Leuprolide|Leuprolide (Lupron)]]
* [[Exemestane|Exemestane (Aromasin)]]
* [[Letrozole|Letrozole (Femara)]]
* [[Mitotane|Mitotane (Lysodren)]]


===== Androgen receptor inhibitors =====
===== GnRH antagonists =====
*[[Nilutamide|Nilutamide (Nilandron)]]
* [[Degarelix|Degarelix (Firmagon)]]


===== 5α-reductase inhibitors =====
----


===== GnRH agonists =====
=== Biologics ===
* [[Buserelin|Buserelin (Superfact)]]
* [[Goserelin Acetate|Goserelin Acetate (Zoladex)]]
* [[Leuprolide|Leuprolide (Lupron)]]


===== GnRH antagonists =====
===== Monoclonal antibodies =====
*[[Degarelix|Degarelix (Firmagon)]]


===== Aromatase inhibitors =====
====== Anti-CD20 antibodies ======
*[[Anastrozole|Anastrozole (Arimidex)]]
* [[Rituximab|Rituximab (Rituxan)]]
*[[Exemestane|Exemestane (Aromasin))]]
* [[Ibritumomab|Ibritumomab (Zevalin)]]
*[[Letrozole|Letrozole (Femara)]]
* [[Obinutuzumab|Obinutuzumab (Gazyva)]]
===== Selective estrogen receptor modulators =====
* [[Ofatumumab|Ofatumumab (Arzerra)]]


----
====== Anti-CD30 antibodies ======
* [[Brentuximab|Brentuximab (Adcetris)]]


{{Button|Biologics}}
====== Anti-CD33 antibodies ======
* [[Gemtuzumab|Gemtuzumab (Mylotarg)]]


===== Antibody medications =====
====== Anti-CD52 antibodies ======
*[[Cetuximab|Cetuximab (Erbitux)]]
* [[Alemtuzumab|Alemtuzumab (Campath)]]
*[[Denosumab|Denosumab (Xgeva)]]
*[[Ibritumomab tiuxetan|Ibritumomab tiuxetan (Zevalin)]]
*[[Ipilimumab|Ipilimumab (Yervoy)]]
*[[Nivolumab |Nivolumab (Opdivo)]]
*[[Obinutuzumab|Obinutuzumab (Gazyva)]]
*[[Ofatumumab|Ofatumumab (Arzerra)]]
*[[Pembrolizumab|Pembrolizumab (KEYTRUDA)]]


====== Anti-CTLA–4 antibodies ======
* [[Ipilimumab|Ipilimumab (Yervoy)]]


===== Antibody-drug conjugates =====
====== Anti-EGFR (ErbB1) antibodies ======
*[[Ado-trastuzumab emtansine|Ado-trastuzumab emtansine (Kadcyla)]]
* [[Cetuximab|Cetuximab (Erbitux)]]
*[[Brentuximab vedotin|Brentuximab vedotin (Adcetris)]]
* [[Panitumumab|Panitumumab (Vectibix)]]
*[[Gemtuzumab ozogamicin|Gemtuzumab ozogamicin (Mylotarg)]]


===== Anti-HER2 medications =====
====== Anti-PD–1 antibodies ======
*[[Ado-trastuzumab emtansine|Ado-trastuzumab emtansine (Kadcyla)]]
* [[Nivolumab |Nivolumab (Opdivo)]]
*[[Trastuzumab|Trastuzumab (Herceptin)]]
* [[Pembrolizumab|Pembrolizumab (Keytruda)]]


===== Enzymes =====
====== Anti-HER2/neu (ErbB2) antibodies ======
*[[Pegaspargase|Pegaspargase (Oncaspar)]]
* [[Ado-trastuzumab emtansine|Ado-trastuzumab emtansine (Kadcyla)]]
*[[Glucarpidase|Glucarpidase (Voraxaze)]]
* [[Trastuzumab|Trastuzumab (Herceptin)]]


===== IL-6 inhibitors =====
====== Anti-VEGF antibodies ======
*[[Siltuximab|Siltuximab (Sylvant)]]
* [[Bevacizumab|Bevacizumab (Avastin)]]


===== IL-2 inhibitors =====
===== IL-2 inhibitors =====
* [[Aldesleukin|Aldesleukin (Proleukin)]]
* [[Denileukin diftitox|Denileukin diftitox (Ontak)]]
* [[Denileukin diftitox|Denileukin diftitox (Ontak)]]
===== IL-6 inhibitors =====
* [[Siltuximab|Siltuximab (Sylvant)]]


===== Immunotherapy =====
===== Immunotherapy =====
*[[Interferon alfa-2b|Interferon alfa-2b (Intron A)]]
* [[Interferon alfa-2b|Interferon alfa-2b (Intron A)]]
 
===== Immunomodulatory drugs (IMiDs) =====
 
* [[Everolimus|Everolimus (Afinitor)]]
* [[Lenalidomide|Lenalidomide (Revlimid)]]
* [[Pomalidomide|Pomalidomide (Pomalyst)]]


----
----


{{Button|Hematopoietic Growth Factors}}
=== Hematopoietic Growth Factors ===


===== Erythrocyte growth factors =====
===== Erythrocyte growth factors =====
*[[Erythropoietin|Erythropoietin (Procrit)]]
* [[Erythropoietin|Erythropoietin (Procrit)]]


===== Granulocyte growth factors =====
===== Granulocyte growth factors =====
*[[Filgrastim|Filgrastim (Granix)]]
* [[Filgrastim|Filgrastim (Granix)]]
*[[Sargramostim|Sargramostin (Leukine)]]
* [[Sargramostim|Sargramostin (Leukine)]]
*[[Tbo-filgrastim|Tbo-filgrastim (Granix)]]
* [[Tbo-filgrastim|Tbo-filgrastim (Granix)]]


===== Megakaryocyte growth factors =====
===== Megakaryocyte growth factors =====
* [[Eltrombopag|Eltrombopag (Promacta)]]
* [[Eltrombopag|Eltrombopag (Promacta)]]
* [[Romiplostim|Romiplostim (Nplate)]]


----
----


{{Button|Supportive Medications}}
=== Supportive Medications ===


===== Chemotherapy protective agents =====
===== Chemotherapy protective agents =====
*[[Amifostine|Amifostine (Ethyol)]]
* [[Amifostine|Amifostine (Ethyol)]]
*[[Cyanocobalamin|Cyanocobalamin]]
* [[Cyanocobalamin|Cyanocobalamin]]
*[[Dexrazoxane|Dexrazoxane (Zinecard)]]
* [[Dexrazoxane|Dexrazoxane (Zinecard)]]
*[[Folinic acid|Folinic acid (Leucovorin)]]
* [[Folinic acid|Folinic acid (Leucovorin)]]
*[[Glucarpidase|Glucarpidase (Voraxaze)]]
* [[Glucarpidase|Glucarpidase (Voraxaze)]]
*[[Levoleucovorin|Levoleucovorin (Fusilev)]]
* [[Levoleucovorin|Levoleucovorin (Fusilev)]]
*[[Mesna|Mesna (Mesnex)]]
* [[Mesna|Mesna (Mesnex)]]


===== Antiemetic agents =====
===== Antiemetic agents =====
*[[Netupitant and palonosetron |Netupitant and palonosetron (Akynzeo)]]
* [[Netupitant and palonosetron |Netupitant and palonosetron (Akynzeo)]]


===== RANK ligand inhibitors =====
===== RANK ligand inhibitors =====
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----
----


{{Button|Miscellaneous}}
=== Miscellaneous ===
===== Antibiotic =====
*[[Mitomycin C|Mitomycin C (Mutamycin)]]


===== Mitotic inhibitors =====
* [[Eribulin|Eribulin (Halaven)]]
* [[Ixabepilone|Ixabepilone (Ixempra)]]


===== Bisphosphonate =====
===== Bisphosphonates =====
* [[Zoledronic Acid|Zoledronic Acid (Zometa)]]
* [[Zoledronic Acid|Zoledronic Acid (Zometa)]]
===== Endocrine-Metabolic agents =====
* [[Fluoxymesterone|Fluoxymesterone (Halotestin)]]
* [[Medroxyprogesterone acetate|Medroxyprogesterone acetate (Provera)]]
* [[Megestrol|Megestrol (Megace)]]


===== HDAC inhibitors =====
===== HDAC inhibitors =====
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===== Hedgehog pathway inhibitors =====
===== Hedgehog pathway inhibitors =====
* [[Vismodegib|Vismodegib (Erivedge)]]
* [[Vismodegib|Vismodegib (Erivedge)]]
===== Immunomodulatory drugs (IMiDs) =====
* [[Everolimus|Everolimus (Afinitor)]]
* [[Lenalidomide|Lenalidomide (Revlimid)]]
* [[Pomalidomide|Pomalidomide (Pomalyst)]]


===== Kinase inhibitors =====
===== Kinase inhibitors =====
* [[Afatinib|Afatinib (Gliotrif)]]
* [[Afatinib|Afatinib (Gliotrif)]]
* [[Cabozantinib|Cabozantinib (Cometriq)]]
* [[Cabozantinib|Cabozantinib (Cometriq)]]
Line 245: Line 259:
* [[Dasatinib|Dasatinib (Sprycel)]]
* [[Dasatinib|Dasatinib (Sprycel)]]
* [[Erlotinib|Erlotinib (Tarceva)]]
* [[Erlotinib|Erlotinib (Tarceva)]]
* [[Gefitinib|Gefitinib (Iressa)]]
* [[Ibrutinib|Ibrutinib (Imbruvica)]]
* [[Ibrutinib|Ibrutinib (Imbruvica)]]
* [[Idelalisib|Idelalisib (Zydelig)]]
* [[Idelalisib|Idelalisib (Zydelig)]]
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* [[Nilotinib|Nilotinib (Tasigna)]]
* [[Nilotinib|Nilotinib (Tasigna)]]
* [[Palbociclib|Palbociclib (Ibrance)]]
* [[Palbociclib|Palbociclib (Ibrance)]]
* [[Sorafenib|Sorafenib (Nexavar)]]
* [[Sunitinib|Sunitinib (Sutent)]]
===== mTOR Inhibitors =====
* [[Temsirolimus|Temsirolimus (Torisel)]]
* [[Everolimus|Everolimus (Afinitor)]]
===== Proteasome inhibitors =====
* [[Bortezomib|Bortezomib (Velcade)]]
* [[Carfilzomib|Carfilzomib (Kyprolis)]]


===== Radioactive agents =====
===== Radioactive agents =====
* [[Radium-223 chloride|Radium-223 chloride (Xofigo)]]
* [[Radium-223 chloride|Radium-223 chloride (Xofigo)]]


===== Somatostatin analogues =====
===== Somatostatin analogs =====
* [[Octreotide|Octreotide (Octreotide)]]
* [[Octreotide|Octreotide (Octreotide)]]


Latest revision as of 18:00, 25 February 2015

Chemotherapeutic Agents by Category

Alkylating agents

Nitrogen mustards
Ethylenimines
Methylhydrazines
Alkylsulfonates
Nitrosoureas
Triazenes
Platinum coordination complexes

Antimetabolites

Folic acid analogs
Pyrimidine analogs
Purine analogs
Ribonucleotide reductase inhibitors

Natural products

Vinca alkaloids
Taxanes
Epipodophyllotoxins
Camptothecins
Anthracyclines
Antineoplastic enzymes

Hormones and Antagonists

Adrenocortical suppressants
Adrenocortico-steroids
Progestins
Anti-estrogens
Aromatase inhibitors
Androgens
Anti-androgens
GnRH agonists
GnRH antagonists

Biologics

Monoclonal antibodies
Anti-CD20 antibodies
Anti-CD30 antibodies
Anti-CD33 antibodies
Anti-CD52 antibodies
Anti-CTLA–4 antibodies
Anti-EGFR (ErbB1) antibodies
Anti-PD–1 antibodies
Anti-HER2/neu (ErbB2) antibodies
Anti-VEGF antibodies
IL-2 inhibitors
IL-6 inhibitors
Immunotherapy

Hematopoietic Growth Factors

Erythrocyte growth factors
Granulocyte growth factors
Megakaryocyte growth factors

Supportive Medications

Chemotherapy protective agents
Antiemetic agents
RANK ligand inhibitors

Miscellaneous

Mitotic inhibitors
Bisphosphonates
HDAC inhibitors
Hedgehog pathway inhibitors
Immunomodulatory drugs (IMiDs)
Kinase inhibitors
mTOR Inhibitors
Proteasome inhibitors
Radioactive agents
Somatostatin analogs
VEGF receptor-2 antagonists
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