Multiple endocrine neoplasia type 2 history and symptoms: Difference between revisions

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{{CMG}}; {{AE}} {{Ammu}}
{{CMG}}; {{AE}} {{Ammu}}
==Overview==
==Overview==
Symptoms of multiple endocrine neoplasia type 2 include [[headache]], hoarseness of voice, [[palpitation]]s, [[anxiety]], [[pallor]] and [[weight loss]].
The hallmark of multiple endocrine neoplasia type 2 is [finding]. A positive history of [finding 1] and [finding 2] is suggestive of [disease name]. The most common symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3]. Common symptoms of [disease] include [symptom 1], [symptom 2], and [symptom 3]. Less common symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3].
==History==
==Diagnosis==
The current clinical criterea  for detecting Multiple endocrine neoplasia type 2 is as follows:<ref name=Genetics>{{cite web | title = Genetics-University of Washington, Seattle) | url =http://www.ncbi.nlm.nih.gov/books/NBK1116/}}</ref>
{| style="border: 2px solid #DCDCDC; font-size: 90%; width: 60%;" align=left
! style="padding: 0 5px; font-size: 120%; background: #4479BA" align=left| ''{{fontcolor|#FFF|Clinical criterea for diagnosis of Multiple endocrine neoplasia type 2}}''
|-
! style="padding: 0 5px; font-size: 95%; background:  #DCDCDC" align=left| '''2 or more specific endocrine tumors ([[medullary thyroid carcinoma]], [[pheochromocytoma]] or [[parathyroid]] hyperplasia)'''
|-
! style="padding: 0 5px; font-size: 95%; background:  #DCDCDC" align=left | '''Familial medullary thyroid carcinoma is diagnosed in families with four or more cases of medullary thryoid cacrinoma without [[pheochromocytoma]] and [[parathyroid]] [[adenoma]]'''
|-
! style="padding: 0 5px; font-size: 95%; background:  #DCDCDC" align=left | '''Multiple endocrine neoplasia type 2b is diagnosed if there is early onset of medullary throid carcinoma, mucosal neuromas of [[lip]]s and [[tongue]], disctinctive facial features with enlarged [[lip]]s and marfanoid body habitus'''
|}
<br><br><br><br><br><br>


==Symptoms==
==History and Symptoms==
===Constitutional Symptoms===
* Tall, thin, "[[Marfan syndrome|marfanoid]]" body build, in which long [[bone]]s are disproportionately elongated.
* Tall, thin, "[[Marfan syndrome|marfanoid]]" body build, in which long [[bone]]s are disproportionately elongated
* Masses beneath [[mucosal]] surfaces in the [[mouth]], [[lip]]s, and [[eye]]s. Numerous yellowish-white, sessile, painless [[Nodule (medicine)|nodules]] on the [[lip]]s or [[tongue]], with deeper lesions having normal coloration. There may be enough [[neuroma]]s in the [[body]] of the [[lip]]s to produce enlargement and a "blubbery [[lip]]" appearance. Similar [[Nodule (medicine)|nodules]] may be seen on the [[sclera]] and [[eyelid]]s
* Masses beneath mucosal surfaces in the [[mouth]], [[lip]]s, and [[eye]]s. Numerous yellowish-white, sessile, painless nodules on the [[lip]]s or [[tongue]], with deeper lesions having normal coloration. There may be enough [[neuroma]]s in the body of the [[lip]]s to produce enlargement and a "blubbery lip" appearance. Similar nodules may be seen on the [[sclera]] and [[eyelid]]s.
* Low [[muscle]] [[mass]], sometimes with [[myopathy]]
* Low [[muscle]] mass, sometimes with [[myopathy]]
* [[Pallor]]
* [[Weight loss]]
* [[Weight loss]]
* Delayed puberty
* [[Delayed puberty]]
* [[Sweating]]
* [[Sweating]]
* Hand [[tremor]]
*[[Hand]] [[tremor]]
* Sleeping difficulty
* [[Sleeping difficulty]]
* [[Lethargy]]
* [[Lethargy]]
===Gastrointestinal Symptoms===
===Gastrointestinal Symptoms===
* Gastrointestinal complaints, especially [[constipation]]
* [[Dysphagia|Trouble swallowing]]
* A nodule, [[lump]], or swelling in the [[neck]]
* [[Pain]] in the front of the [[neck]]
* [[Hoarseness]] or other voice changes
* Trouble [[swallowing]]
* [[Diarrhea]]
* [[Diarrhea]]
* [[Abdominal pain]]
* [[Abdominal pain]]
* [[Constipation]]
* [[Constipation]]
* [[Nausea]]
* [[Nausea]]
* Decreased appetite
* [[Anorexia|Decreased appetite]]
 
===Respiratory Symptoms===
===Respiratory Symptoms===
* Breathing problems
*[[Breathing]] problems
* Continuous [[cough]]
* Continuous [[cough]]
* [[Cough]] with [[blood]]
* [[Cough]] with [[blood]]
===Cardiovascular Symptoms===
===Cardiovascular Symptoms===
* [[Chest pain]]
* [[Chest pain]]
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* [[Anxiety]] often resembling that of a [[panic attack]]
* [[Anxiety]] often resembling that of a [[panic attack]]
* [[Diaphoresis]]
* [[Diaphoresis]]
===Neurologic Symptoms===
===Neurologic Symptoms===
* [[Headaches]]
* [[Headaches]]
* Irritability
*[[Irritability]]
* Nervousness
* Nervousness
* [[Confusion]]
* [[Confusion]]
===Ophthalmology Symptoms===
===Ophthalmology Symptoms===
* [[Dry eye]]s or lack of tears, which is an especially helpful sign in children
* [[Dry eye]]s or lack of [[tears]], which is an especially helpful [[Medical sign|sign]] in children.


==References==
==References==
{{reflist|2}}
{{reflist|2}}
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Latest revision as of 12:13, 24 June 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]

Overview

The hallmark of multiple endocrine neoplasia type 2 is [finding]. A positive history of [finding 1] and [finding 2] is suggestive of [disease name]. The most common symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3]. Common symptoms of [disease] include [symptom 1], [symptom 2], and [symptom 3]. Less common symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3].

History and Symptoms

Gastrointestinal Symptoms

Respiratory Symptoms

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References

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