Multiple endocrine neoplasia type 2 other diagnostic studies

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]

Overview

Other diagnostic studies for multiple endocrine neoplasia type 2 include molecular genetic testing which include sequence analysis of select exons of mainly 10,11, 13-16 and sequence analysis of RET gene.

Other Diagnostic Studies

Molecular Genetic Testing

Molecular genetic testing

Test	Method
Select exon testing	Sequence analysis of select exons of mainly 10,11, 13-16
Single-gene testing	Sequence analysis of RET gene
A multi-gene panel	RET and other genes of interest

Histopathological Staining of the Biopsy

• Histopathological staining of medullary thyroid cancer

1. Calcitonin: positive in tumor cells
2. Chromogranin: positive in tumor cells
3. Synaptophysin: positive in tumor cells

References

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