KCNK1: Difference between revisions

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{{Infobox_gene}}
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'''Potassium channel subfamily K member 1''' is a [[protein]] that in humans is encoded by the ''KCNK1'' [[gene]].<ref name="pmid8661042">{{cite journal |vauthors=Lesage F, Mattei M, Fink M, Barhanin J, Lazdunski M | title = Assignment of the human weak inward rectifier K+ channel TWIK-1 gene to chromosome 1q42-q43 | journal = Genomics | volume = 34 | issue = 1 | pages = 153–5 |date=Dec 1996 | pmid = 8661042 | pmc = | doi =10.1006/geno.1996.0259 }}</ref><ref name="pmid16382106">{{cite journal |vauthors=Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S | title = International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels | journal = Pharmacol Rev | volume = 57 | issue = 4 | pages = 527–40 |date=Dec 2005 | pmid = 16382106 | pmc =  | doi = 10.1124/pr.57.4.12 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: KCNK1 potassium channel, subfamily K, member 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3775| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Potassium channel, subfamily K, member 1
| HGNCid = 6272
| Symbol = KCNK1
| AltSymbols =; DPK; HOHO; K2p1.1; TWIK-1; TWIK1
| OMIM = 601745
| ECnumber = 
| Homologene = 1691
| MGIid = 109322
| Function = {{GNF_GO|id=GO:0005216 |text = ion channel activity}} {{GNF_GO|id=GO:0005242 |text = inward rectifier potassium channel activity}} {{GNF_GO|id=GO:0005244 |text = voltage-gated ion channel activity}} {{GNF_GO|id=GO:0005267 |text = potassium channel activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0030955 |text = potassium ion binding}}
  | Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005768 |text = endosome}} {{GNF_GO|id=GO:0008076 |text = voltage-gated potassium channel complex}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006813 |text = potassium ion transport}}
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3775
    | Hs_Ensembl = 
    | Hs_RefseqProtein = NP_002236
    | Hs_RefseqmRNA = NM_002245
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 
    | Hs_GenLoc_start = 
    | Hs_GenLoc_end = 
    | Hs_Uniprot = 
    | Mm_EntrezGene = 16525
    | Mm_Ensembl = ENSMUSG00000033998
    | Mm_RefseqmRNA = NM_008430
    | Mm_RefseqProtein = NP_032456
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 8
    | Mm_GenLoc_start = 128881260
    | Mm_GenLoc_end = 128916775
    | Mm_Uniprot = Q99L99
  }}
}}
'''Potassium channel, subfamily K, member 1''', also known as '''KCNK1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: KCNK1 potassium channel, subfamily K, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3775| accessdate = }}</ref>


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{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, it may require other non-pore-forming proteins for activity.<ref name="entrez">{{cite web | title = Entrez Gene: KCNK1 potassium channel, subfamily K, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3775| accessdate = }}</ref>
| summary_text = This gene encodes K<sub>2P</sub>1.1, a member of the superfamily of [[potassium channel]] [[protein]]s containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, and it may require other non-pore-forming proteins for activity.<ref name="entrez" />
}}
}}


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==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
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| citations =  
| citations =  
*{{cite journal  | author=Goldstein SA, Wang KW, Ilan N, Pausch MH |title=Sequence and function of the two P domain potassium channels: implications of an emerging superfamily. |journal=J. Mol. Med. |volume=76 |issue= 1 |pages= 13-20 |year= 1998 |pmid= 9462864 |doi=  }}
*{{cite journal  |vauthors=Goldstein SA, Wang KW, Ilan N, Pausch MH |title=Sequence and function of the two P domain potassium channels: implications of an emerging superfamily |journal=J. Mol. Med. |volume=76 |issue= 1 |pages= 13–20 |year= 1998 |pmid= 9462864 |doi=10.1007/s109-1998-8100-0 }}
*{{cite journal  | author=Lesage F, Lazdunski M |title=Molecular and functional properties of two-pore-domain potassium channels. |journal=Am. J. Physiol. Renal Physiol. |volume=279 |issue= 5 |pages= F793-801 |year= 2000 |pmid= 11053038 |doi=  }}
*{{cite journal  |vauthors=Lesage F, Lazdunski M |title=Molecular and functional properties of two-pore-domain potassium channels |journal=Am. J. Physiol. Renal Physiol. |volume=279 |issue= 5 |pages= F793–801 |year= 2000 |pmid= 11053038 |doi=  }}
*{{cite journal  | author=Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N |title=Potassium leak channels and the KCNK family of two-P-domain subunits. |journal=Nat. Rev. Neurosci. |volume=2 |issue= 3 |pages= 175-84 |year= 2001 |pmid= 11256078 |doi=  }}
*{{cite journal  |vauthors=Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N |title=Potassium leak channels and the KCNK family of two-P-domain subunits |journal=Nat. Rev. Neurosci. |volume=2 |issue= 3 |pages= 175–84 |year= 2001 |pmid= 11256078 |doi=10.1038/35058574  }}
*{{cite journal  | author=Goldstein SA, Bayliss DA, Kim D, ''et al.'' |title=International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels. |journal=Pharmacol. Rev. |volume=57 |issue= 4 |pages= 527-40 |year= 2006 |pmid= 16382106 |doi= 10.1124/pr.57.4.12 }}
*{{cite journal  | author=Lesage F |title=TWIK-1, a ubiquitous human weakly inward rectifying K+ channel with a novel structure |journal=EMBO J. |volume=15 |issue= 5 |pages= 1004–11 |year= 1996 |pmid= 8605869 |doi=  | pmc=449995  |name-list-format=vanc| author2=Guillemare E | author3=Fink M | display-authors=3  | last4=Duprat  | first4=F  | last5=Lazdunski  | first5=M  | last6=Romey  | first6=G  | last7=Barhanin  | first7=J }}
*{{cite journal  | author=Lesage F, Guillemare E, Fink M, ''et al.'' |title=TWIK-1, a ubiquitous human weakly inward rectifying K+ channel with a novel structure. |journal=EMBO J. |volume=15 |issue= 5 |pages= 1004-11 |year= 1996 |pmid= 8605869 |doi=  }}
*{{cite journal  | author=Lesage F |title=Dimerization of TWIK-1 K+ channel subunits via a disulfide bridge |journal=EMBO J. |volume=15 |issue= 23 |pages= 6400–7 |year= 1997 |pmid= 8978667 |doi= | pmc=452465  |name-list-format=vanc| author2=Reyes R  | author3=Fink M  | display-authors=3  | last4=Duprat  | first4=F  | last5=Guillemare  | first5=E  | last6=Lazdunski  | first6=M }}
*{{cite journal | author=Lesage F, Mattéi M, Fink M, ''et al.'' |title=Assignment of the human weak inward rectifier K+ channel TWIK-1 gene to chromosome 1q42-q43. |journal=Genomics |volume=34 |issue= 1 |pages= 153-5 |year= 1996 |pmid= 8661042 |doi=  }}
*{{cite journal  | author=Orias M |title=Cloning and localization of a double-pore K channel, KCNK1: exclusive expression in distal nephron segments |journal=Am. J. Physiol. |volume=273 |issue= 4 Pt 2 |pages= F663–6 |year= 1997 |pmid= 9362344 |doi= |name-list-format=vanc| author2=Velázquez H  | author3=Tung F  | display-authors=3  | last4=Lee  | first4=G  | last5=Desir  | first5=GV }}
*{{cite journal  | author=Lesage F, Reyes R, Fink M, ''et al.'' |title=Dimerization of TWIK-1 K+ channel subunits via a disulfide bridge. |journal=EMBO J. |volume=15 |issue= 23 |pages= 6400-7 |year= 1997 |pmid= 8978667 |doi=  }}
*{{cite journal  | author=Wang Z |title=Differential distribution of inward rectifier potassium channel transcripts in human atrium versus ventricle |journal=Circulation |volume=98 |issue= 22 |pages= 2422–8 |year= 1999 |pmid= 9832487 |doi= 10.1161/01.cir.98.22.2422|name-list-format=vanc| author2=Yue L  | author3=White M  | display-authors=3  | last4=Pelletier  | first4=G  | last5=Nattel  | first5=S }}
*{{cite journal  | author=Orias M, Velázquez H, Tung F, ''et al.'' |title=Cloning and localization of a double-pore K channel, KCNK1: exclusive expression in distal nephron segments. |journal=Am. J. Physiol. |volume=273 |issue= 4 Pt 2 |pages= F663-6 |year= 1997 |pmid= 9362344 |doi=  }}
*{{cite journal  | author=Medhurst AD |title=Distribution analysis of human two pore domain potassium channels in tissues of the central nervous system and periphery |journal=Brain Res. Mol. Brain Res. |volume=86 |issue= 1–2 |pages= 101–14 |year= 2001 |pmid= 11165377 |doi=10.1016/S0169-328X(00)00263-1  |name-list-format=vanc| author2=Rennie G  | author3=Chapman CG  | display-authors=3  | last4=Meadows  | first4=H  | last5=Duckworth  | first5=MD  | last6=Kelsell  | first6=RE  | last7=Gloger  | first7=II  | last8=Pangalos  | first8=MN }}
*{{cite journal  | author=Wang Z, Yue L, White M, ''et al.'' |title=Differential distribution of inward rectifier potassium channel transcripts in human atrium versus ventricle. |journal=Circulation |volume=98 |issue= 22 |pages= 2422-8 |year= 1999 |pmid= 9832487 |doi=  }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Medhurst AD, Rennie G, Chapman CG, ''et al.'' |title=Distribution analysis of human two pore domain potassium channels in tissues of the central nervous system and periphery. |journal=Brain Res. Mol. Brain Res. |volume=86 |issue= 1-2 |pages= 101-14 |year= 2001 |pmid= 11165377 |doi=  }}
*{{cite journal  |vauthors=Nicolas MT, Barhanin J, Reyes R, Demêmes D |title=Cellular localization of TWIK-1, a two-pore-domain potassium channel in the rodent inner ear |journal=Hear. Res. |volume=181 |issue= 1–2 |pages= 20–6 |year= 2004 |pmid= 12855359 |doi=10.1016/S0378-5955(03)00162-X }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-format=vanc| author2=Suzuki Y  | author3=Nishikawa T  | display-authors=3  | last4=Otsuki  | first4=Tetsuji  | last5=Sugiyama  | first5=Tomoyasu  | last6=Irie  | first6=Ryotaro  | last7=Wakamatsu  | first7=Ai  | last8=Hayashi  | first8=Koji  | last9=Sato  | first9=Hiroyuki }}
*{{cite journal  | author=Nicolas MT, Barhanin J, Reyes R, Demêmes D |title=Cellular localization of TWIK-1, a two-pore-domain potassium channel in the rodent inner ear. |journal=Hear. Res. |volume=181 |issue= 1-2 |pages= 20-6 |year= 2004 |pmid= 12855359 |doi=  }}
*{{cite journal  | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Rajan S |title=Sumoylation silences the plasma membrane leak K+ channel K2P1 |journal=Cell |volume=121 |issue= 1 |pages= 37–47 |year= 2005 |pmid= 15820677 |doi= 10.1016/j.cell.2005.01.019 |name-list-format=vanc| author2=Plant LD  | author3=Rabin ML  | display-authors=3  | last4=Butler  | first4=Margaret H.  | last5=Goldstein  | first5=Steve A.N. }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Rual JF |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |name-list-format=vanc| author2=Venkatesan K  | author3=Hao T  | display-authors=3  | last4=Hirozane-Kishikawa  | first4=Tomoko  | last5=Dricot  | first5=Amélie  | last6=Li  | first6=Ning  | last7=Berriz  | first7=Gabriel F.  | last8=Gibbons  | first8=Francis D.  | last9=Dreze  | first9=Matija }}
*{{cite journal  | author=Rajan S, Plant LD, Rabin ML, ''et al.'' |title=Sumoylation silences the plasma membrane leak K+ channel K2P1. |journal=Cell |volume=121 |issue= 1 |pages= 37-47 |year= 2005 |pmid= 15820677 |doi= 10.1016/j.cell.2005.01.019 }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
}}
}}
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{{refend}}
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* {{MeshName|KCNK1+protein,+human}}
* {{MeshName|KCNK1+protein,+human}}


{{membrane-protein-stub}}
{{NLM content}}
{{NLM content}}
{{Ion channels}}
{{Ion channels|g3}}
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[[Category:Ion channels]]
[[Category:Ion channels]]
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{{membrane-protein-stub}}

Latest revision as of 06:15, 2 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Potassium channel subfamily K member 1 is a protein that in humans is encoded by the KCNK1 gene.[1][2][3]

This gene encodes K2P1.1, a member of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, and it may require other non-pore-forming proteins for activity.[3]

See also

References

  1. ↑ Lesage F, Mattei M, Fink M, Barhanin J, Lazdunski M (Dec 1996). "Assignment of the human weak inward rectifier K+ channel TWIK-1 gene to chromosome 1q42-q43". Genomics. 34 (1): 153–5. doi:10.1006/geno.1996.0259. PMID 8661042.
  2. ↑ Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (Dec 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol Rev. 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID 16382106.
  3. ↑ 3.0 3.1 "Entrez Gene: KCNK1 potassium channel, subfamily K, member 1".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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