KCNA4

Potassium voltage-gated channel, shaker-related subfamily, member 4
PDB rendering based on 1kn7.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1kn7​, 1zto​
Identifiers
Symbols	KCNA4 ; HK1; HBK4; HPCN2; HUKII; KCNA4L; KCNA8; KV1.4; PCN2
External IDs	Template:OMIM5 Template:MGI HomoloGene: 20514
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Potassium voltage-gated channel, shaker-related subfamily, member 4, also known as KCNA4 or K_v1.4, is a human gene.

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the A-type potassium current class, the members of which may be important in the regulation of the fast repolarizing phase of action potentials in heart and thus may influnce the duration of cardiac action potential. The coding region of this gene is intronless, and the gene is clustered with genes KCNA3 and KCNA10 on chromosome 1.

See also

• Voltage-gated potassium channel

Further reading

• Gutman GA, Chandy KG, Grissmer S; et al. (2006). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol. Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Scott HS, Litjens T, Hopwood JJ, Morris CP (1993). "PCR detection of two RFLPs in exon I of the alpha-L-iduronidase (IDUA) gene". Hum. Genet. 90 (3): 327. PMID 1362562.CS1 maint: Multiple names: authors list (link)
• Gessler M, Grupe A, Grzeschik KH, Pongs O (1993). "The potassium channel gene HK1 maps to human chromosome 11p14.1, close to the FSHB gene". Hum. Genet. 90 (3): 319–21. PMID 1487251.CS1 maint: Multiple names: authors list (link)
• Philipson LH, Hice RE, Schaefer K; et al. (1991). "Sequence and functional expression in Xenopus oocytes of a human insulinoma and islet potassium channel". Proc. Natl. Acad. Sci. U.S.A. 88 (1): 53–7. PMID 1986382.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tamkun MM, Knoth KM, Walbridge JA; et al. (1991). "Molecular cloning and characterization of two voltage-gated K+ channel cDNAs from human ventricle". FASEB J. 5 (3): 331–7. PMID 2001794.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Philipson LH, Schaefer K, LaMendola J; et al. (1991). "Sequence of a human fetal skeletal muscle potassium channel cDNA related to RCK4". Nucleic Acids Res. 18 (23): 7160. PMID 2263489.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kim E, Niethammer M, Rothschild A; et al. (1995). "Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases". Nature. 378 (6552): 85–8. doi:10.1038/378085a0. PMID 7477295.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Klocke R, Roberds SL, Tamkun MM; et al. (1994). "Chromosomal mapping in the mouse of eight K(+)-channel genes representing the four Shaker-like subfamilies Shaker, Shab, Shaw, and Shal". Genomics. 18 (3): 568–74. PMID 7905852.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Philipson LH, Eddy RL, Shows TB, Bell GI (1993). "Assignment of human potassium channel gene KCNA4 (Kv1.4, PCN2) to chromosome 11q13.4-->q14.1". Genomics. 15 (2): 463–4. doi:10.1006/geno.1993.1094. PMID 8449523.CS1 maint: Multiple names: authors list (link)
• Niethammer M, Kim E, Sheng M (1996). "Interaction between the C terminus of NMDA receptor subunits and multiple members of the PSD-95 family of membrane-associated guanylate kinases". J. Neurosci. 16 (7): 2157–63. PMID 8601796.CS1 maint: Multiple names: authors list (link)
• Kim E, Sheng M (1997). "Differential K+ channel clustering activity of PSD-95 and SAP97, two related membrane-associated putative guanylate kinases". Neuropharmacology. 35 (7): 993–1000. PMID 8938729.
• Kim E, Naisbitt S, Hsueh YP; et al. (1997). "GKAP, a novel synaptic protein that interacts with the guanylate kinase-like domain of the PSD-95/SAP90 family of channel clustering molecules". J. Cell Biol. 136 (3): 669–78. PMID 9024696.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Niethammer M, Valtschanoff JG, Kapoor TM; et al. (1998). "CRIPT, a novel postsynaptic protein that binds to the third PDZ domain of PSD-95/SAP90". Neuron. 20 (4): 693–707. PMID 9581762.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Brenman JE, Topinka JR, Cooper EC; et al. (1998). "Localization of postsynaptic density-93 to dendritic microtubules and interaction with microtubule-associated protein 1A". J. Neurosci. 18 (21): 8805–13. PMID 9786987.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Coleman SK, Newcombe J, Pryke J, Dolly JO (1999). "Subunit composition of Kv1 channels in human CNS". J. Neurochem. 73 (2): 849–58. PMID 10428084.CS1 maint: Multiple names: authors list (link)
• D'Adamo MC, Imbrici P, Sponcichetti F, Pessia M (1999). "Mutations in the KCNA1 gene associated with episodic ataxia type-1 syndrome impair heteromeric voltage-gated K(+) channel function". FASEB J. 13 (11): 1335–45. PMID 10428758.CS1 maint: Multiple names: authors list (link)
• Hogan A, Shepherd L, Chabot J; et al. (2001). "Interaction of gamma 1-syntrophin with diacylglycerol kinase-zeta. Regulation of nuclear localization by PDZ interactions". J. Biol. Chem. 276 (28): 26526–33. doi:10.1074/jbc.M104156200. PMID 11352924.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cukovic D, Lu GW, Wible B; et al. (2001). "A discrete amino terminal domain of Kv1.5 and Kv1.4 potassium channels interacts with the spectrin repeats of alpha-actinin-2". FEBS Lett. 498 (1): 87–92. PMID 11389904.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Imamura F, Maeda S, Doi T, Fujiyoshi Y (2002). "Ligand binding of the second PDZ domain regulates clustering of PSD-95 with the Kv1.4 potassium channel". J. Biol. Chem. 277 (5): 3640–6. doi:10.1074/jbc.M106940200. PMID 11723117.CS1 maint: Multiple names: authors list (link)
• Piserchio A, Pellegrini M, Mehta S; et al. (2002). "The PDZ1 domain of SAP90. Characterization of structure and binding". J. Biol. Chem. 277 (9): 6967–73. doi:10.1074/jbc.M109453200. PMID 11744724.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• Kv1.4+Potassium+Channel at the US National Library of Medicine Medical Subject Headings (MeSH)
• KCNA4+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.