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Interleukin 20 (IL20) is a protein that in humans is encoded by the IL20gene.[1] Interkeukin 20 also includes other cytokines, including IL-19, IL-20, IL-22, IL-24, and IL-26. Based on common structural and functional properties of IL-20's receptors and target cells, these cytokines constitute the same subfamily, IL-20.[2]
Function
The protein encoded by this gene is a cytokine structurally related to interleukin 10 (IL-10). This cytokine has been shown to transduce its signal through signal transducer and activator of transcription 3 (STAT3) in keratinocytes. A specific receptor for this cytokine is found to be expressed in skin and upregulated dramatically in psoriatic skin, suggesting a role for this protein in epidermal function and psoriasis.[1]
Interleukin-20 (IL-20) is a protein belonging to the IL-10 family of cytokines. IL-20 is produced by activated keratinocytes and monocytes and transmits an intracellular signal through two distinct cell-surface receptor complexes on keratinocytes and other epithelial cells. IL-20 regulates proliferation and differentiation of keratinocytes during inflammation, particularly inflammation associated with the skin. In addition, IL-20 also causes cell expansion of multipotential hematopoieticprogenitor cells.[3]
Anti IL-20
Anti-IL-20 monoclonal antibodies have been researched as clinical candidates for the treatment or prevention of psoriasis, rheumatoid arthritis, atherosclerosis, osteoporosis, and stroke.[4][5][6]
↑Rutz S, Wang X, Ouyang W (Dec 2014). "The IL-20 subfamily of cytokines--from host defence to tissue homeostasis". Nature Reviews. Immunology. 14 (12): 783–95. doi:10.1038/nri3766. PMID25421700.
↑Rich BE, Kupper TS (August 2006). "Interleukin 20". Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry. 5 (3): 243–250. doi:10.2174/187152306778017683.
↑Kragstrup TW, Otkjaer K, Holm C, Jørgensen A, Hokland M, Iversen L, Deleuran B (Jan 2008). "The expression of IL-20 and IL-24 and their shared receptors are increased in rheumatoid arthritis and spondyloarthropathy". Cytokine. 41 (1): 16–23. doi:10.1016/j.cyto.2007.10.004. PMID18061474.