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{{PBB|geneid=3708}}
{{Infobox_gene}}
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'''Inositol 1,4,5-trisphosphate receptor type 1''' is a [[protein]] that in humans is encoded by the ''ITPR1'' [[gene]].<ref name="pmid7945203">{{cite journal | vauthors = Yamada N, Makino Y, Clark RA, Pearson DW, Mattei MG, Guénet JL, Ohama E, Fujino I, Miyawaki A, Furuichi T | title = Human inositol 1,4,5-trisphosphate type-1 receptor, InsP3R1: structure, function, regulation of expression and chromosomal localization | journal = The Biochemical Journal | volume = 302 | issue = Pt 3 | pages = 781–90 | date = Sep 1994 | pmid = 7945203 | pmc = 1137299 | doi =  10.1042/bj3020781}}</ref><ref name="pmid7500840">{{cite journal | vauthors = Nucifora FC, Li SH, Danoff S, Ullrich A, Ross CA | title = Molecular cloning of a cDNA for the human inositol 1,4,5-trisphosphate receptor type 1, and the identification of a third alternatively spliced variant | journal = Brain Research. Molecular Brain Research | volume = 32 | issue = 2 | pages = 291–6 | date = Sep 1995 | pmid = 7500840 | pmc =  | doi = 10.1016/0169-328X(95)00089-B }}</ref><ref name="pmid17590087">{{cite journal | vauthors = van de Leemput J, Chandran J, Knight MA, Holtzclaw LA, Scholz S, Cookson MR, Houlden H, Gwinn-Hardy K, Fung HC, Lin X, Hernandez D, Simon-Sanchez J, Wood NW, Giunti P, Rafferty I, Hardy J, Storey E, Gardner RJ, Forrest SM, Fisher EM, Russell JT, Cai H, Singleton AB | title = Deletion at ITPR1 underlies ataxia in mice and spinocerebellar ataxia 15 in humans | journal = PLoS Genetics | volume = 3 | issue = 6 | pages = e108 | date = Jun 2007 | pmid = 17590087 | pmc = 1892049 | doi = 10.1371/journal.pgen.0030108 }}</ref><ref name="pmid17932120">{{cite journal | vauthors = Iwaki A, Kawano Y, Miura S, Shibata H, Matsuse D, Li W, Furuya H, Ohyagi Y, Taniwaki T, Kira J, Fukumaki Y | title = Heterozygous deletion of ITPR1, but not SUMF1, in spinocerebellar ataxia type 16 | journal = Journal of Medical Genetics | volume = 45 | issue = 1 | pages = 32–5 | date = Jan 2008 | pmid = 17932120 | pmc =  | doi = 10.1136/jmg.2007.053942 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ITPR1 inositol 1,4,5-triphosphate receptor, type 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3708| accessdate = }}</ref>


== Interactions ==


'''Inositol 1,4,5-triphosphate receptor, type 1''', also known as '''ITPR1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ITPR1 inositol 1,4,5-triphosphate receptor, type 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3708| accessdate = }}</ref>
ITPR1 has been shown to [[Protein-protein interaction|interact]] with:
{{div col|colwidth=20em}}
* [[AHCYL1]],<ref name = pmid12525476>{{cite journal | vauthors = Ando H, Mizutani A, Matsu-ura T, Mikoshiba K | title = IRBIT, a novel inositol 1,4,5-trisphosphate (IP3) receptor-binding protein, is released from the IP3 receptor upon IP3 binding to the receptor | journal = The Journal of Biological Chemistry | volume = 278 | issue = 12 | pages = 10602–12 | date = Mar 2003 | pmid = 12525476 | doi = 10.1074/jbc.M210119200 }}</ref>
* [[CA8]],<ref name = pmid12611586>{{cite journal | vauthors = Hirota J, Ando H, Hamada K, Mikoshiba K | title = Carbonic anhydrase-related protein is a novel binding protein for inositol 1,4,5-trisphosphate receptor type 1 | journal = The Biochemical Journal | volume = 372 | issue = Pt 2 | pages = 435–41 | date = Jun 2003 | pmid = 12611586 | pmc = 1223404 | doi = 10.1042/BJ20030110 }}</ref>
* [[EPB41L1]]<ref name = pmid12676536>{{cite journal | vauthors = Maximov A, Tang TS, Bezprozvanny I | title = Association of the type 1 inositol (1,4,5)-trisphosphate receptor with 4.1N protein in neurons | journal = Molecular and Cellular Neurosciences | volume = 22 | issue = 2 | pages = 271–83 | date = Feb 2003 | pmid = 12676536 | doi =  10.1016/s1044-7431(02)00027-1}}</ref>
* [[FKBP1A]],<ref name = pmid16278292>{{cite journal | vauthors = MacMillan D, Currie S, Bradley KN, Muir TC, McCarron JG | title = In smooth muscle, FK506-binding protein modulates IP3 receptor-evoked Ca2+ release by mTOR and calcineurin | journal = Journal of Cell Science | volume = 118 | issue = Pt 23 | pages = 5443–51 | date = Dec 2005 | pmid = 16278292 | doi = 10.1242/jcs.02657 }}</ref><ref name = pmid9346894>{{cite journal | vauthors = Cameron AM, Nucifora FC, Fung ET, Livingston DJ, Aldape RA, Ross CA, Snyder SH | title = FKBP12 binds the inositol 1,4,5-trisphosphate receptor at leucine-proline (1400-1401) and anchors calcineurin to this FK506-like domain | journal = The Journal of Biological Chemistry | volume = 272 | issue = 44 | pages = 27582–8 | date = Oct 1997 | pmid = 9346894 | doi =  10.1074/jbc.272.44.27582}}</ref>
* [[MRVI1]],<ref name = pmid10724174/>
* [[PRKG1]],<ref name = pmid10724174>{{cite journal | vauthors = Schlossmann J, Ammendola A, Ashman K, Zong X, Huber A, Neubauer G, Wang GX, Allescher HD, Korth M, Wilm M, Hofmann F, Ruth P | title = Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase Ibeta | journal = Nature | volume = 404 | issue = 6774 | pages = 197–201 | date = Mar 2000 | pmid = 10724174 | doi = 10.1038/35004606 }}</ref>
* [[RHOA]],<ref name = pmid12766172>{{cite journal | vauthors = Mehta D, Ahmmed GU, Paria BC, Holinstat M, Voyno-Yasenetskaya T, Tiruppathi C, Minshall RD, Malik AB | title = RhoA interaction with inositol 1,4,5-trisphosphate receptor and transient receptor potential channel-1 regulates Ca2+ entry. Role in signaling increased endothelial permeability | journal = The Journal of Biological Chemistry | volume = 278 | issue = 35 | pages = 33492–500 | date = Aug 2003 | pmid = 12766172 | doi = 10.1074/jbc.M302401200 }}</ref>  and
* [[TRPC4]].<ref name = pmid14505576>{{cite journal | vauthors = Yuan JP, Kiselyov K, Shin DM, Chen J, Shcheynikov N, Kang SH, Dehoff MH, Schwarz MK, Seeburg PH, Muallem S, Worley PF | title = Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors | journal = Cell | volume = 114 | issue = 6 | pages = 777–89 | date = Sep 2003 | pmid = 14505576 | doi =  10.1016/s0092-8674(03)00716-5}}</ref><ref name = pmid11163362>{{cite journal | vauthors = Mery L, Magnino F, Schmidt K, Krause KH, Dufour JF | title = Alternative splice variants of hTrp4 differentially interact with the C-terminal portion of the inositol 1,4,5-trisphosphate receptors | journal = FEBS Letters | volume = 487 | issue = 3 | pages = 377–83 | date = Jan 2001 | pmid = 11163362 | doi =  10.1016/s0014-5793(00)02362-0}}</ref>
{{Div col end}}


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== See also ==
{{PBB_Summary
| section_title =
| summary_text =
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==See also==
* [[Inositol triphosphate]]
* [[Inositol triphosphate]]
* [[Inositol triphosphate receptor]]
* [[Inositol triphosphate receptor]]


==References==
== References ==
{{reflist|2}}
{{reflist}}
{{clear}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Stove V, Verhasselt B | title = Modelling thymic HIV-1 Nef effects | journal = Current HIV Research | volume = 4 | issue = 1 | pages = 57–64 | date = Jan 2006 | pmid = 16454711 | doi = 10.2174/157016206775197583 }}
| citations =
* {{cite journal | vauthors = Joseph SK, Lin C, Pierson S, Thomas AP, Maranto AR | title = Heteroligomers of type-I and type-III inositol trisphosphate receptors in WB rat liver epithelial cells | journal = The Journal of Biological Chemistry | volume = 270 | issue = 40 | pages = 23310–6 | date = Oct 1995 | pmid = 7559486 | doi = 10.1074/jbc.270.40.23310 }}
*{{cite journal | author=Stove V, Verhasselt B |title=Modelling thymic HIV-1 Nef effects. |journal=Curr. HIV Res. |volume=4 |issue= 1 |pages= 57–64 |year= 2006 |pmid= 16454711 |doi= }}
* {{cite journal | vauthors = Harnick DJ, Jayaraman T, Ma Y, Mulieri P, Go LO, Marks AR | title = The human type 1 inositol 1,4,5-trisphosphate receptor from T lymphocytes. Structure, localization, and tyrosine phosphorylation | journal = The Journal of Biological Chemistry | volume = 270 | issue = 6 | pages = 2833–40 | date = Feb 1995 | pmid = 7852357 | doi = 10.1074/jbc.270.6.2833 }}
*{{cite journal | author=Nucifora FC, Li SH, Danoff S, ''et al.'' |title=Molecular cloning of a cDNA for the human inositol 1,4,5-trisphosphate receptor type 1, and the identification of a third alternatively spliced variant. |journal=Brain Res. Mol. Brain Res. |volume=32 |issue= 2 |pages= 291–6 |year= 1996 |pmid= 7500840 |doi= }}
* {{cite journal | vauthors = Wojcikiewicz RJ, Furuichi T, Nakade S, Mikoshiba K, Nahorski SR | title = Muscarinic receptor activation down-regulates the type I inositol 1,4,5-trisphosphate receptor by accelerating its degradation | journal = The Journal of Biological Chemistry | volume = 269 | issue = 11 | pages = 7963–9 | date = Mar 1994 | pmid = 8132516 | doi =  }}
*{{cite journal | author=Joseph SK, Lin C, Pierson S, ''et al.'' |title=Heteroligomers of type-I and type-III inositol trisphosphate receptors in WB rat liver epithelial cells. |journal=J. Biol. Chem. |volume=270 |issue= 40 |pages= 23310–6 |year= 1995 |pmid= 7559486 |doi= }}
* {{cite journal | vauthors = Komalavilas P, Lincoln TM | title = Phosphorylation of the inositol 1,4,5-trisphosphate receptor by cyclic GMP-dependent protein kinase | journal = The Journal of Biological Chemistry | volume = 269 | issue = 12 | pages = 8701–7 | date = Mar 1994 | pmid = 8132598 | doi =  }}
*{{cite journal | author=Harnick DJ, Jayaraman T, Ma Y, ''et al.'' |title=The human type 1 inositol 1,4,5-trisphosphate receptor from T lymphocytes. Structure, localization, and tyrosine phosphorylation. |journal=J. Biol. Chem. |volume=270 |issue= 6 |pages= 2833–40 |year= 1995 |pmid= 7852357 |doi=  }}
* {{cite journal | vauthors = Cameron AM, Steiner JP, Roskams AJ, Ali SM, Ronnett GV, Snyder SH | title = Calcineurin associated with the inositol 1,4,5-trisphosphate receptor-FKBP12 complex modulates Ca2+ flux | journal = Cell | volume = 83 | issue = 3 | pages = 463–72 | date = Nov 1995 | pmid = 8521476 | doi = 10.1016/0092-8674(95)90124-8 }}
*{{cite journal | author=Yamada N, Makino Y, Clark RA, ''et al.'' |title=Human inositol 1,4,5-trisphosphate type-1 receptor, InsP3R1: structure, function, regulation of expression and chromosomal localization. |journal=Biochem. J. |volume=302 ( Pt 3) |issue= |pages= 781–90 |year= 1994 |pmid= 7945203 |doi=  }}
* {{cite journal | vauthors = Yan J, Khanna KK, Lavin MF | title = Induction of inositol 1,4,5 trisphosphate receptor genes by ionizing radiation | journal = International Journal of Radiation Biology | volume = 69 | issue = 5 | pages = 539–46 | date = May 1996 | pmid = 8648241 | doi = 10.1080/095530096145544 }}
*{{cite journal | author=Wojcikiewicz RJ, Furuichi T, Nakade S, ''et al.'' |title=Muscarinic receptor activation down-regulates the type I inositol 1,4,5-trisphosphate receptor by accelerating its degradation. |journal=J. Biol. Chem. |volume=269 |issue= 11 |pages= 7963–9 |year= 1994 |pmid= 8132516 |doi= }}
* {{cite journal | vauthors = Quinton TM, Dean WL | title = Multiple inositol 1,4,5-trisphosphate receptor isoforms are present in platelets | journal = Biochemical and Biophysical Research Communications | volume = 224 | issue = 3 | pages = 740–6 | date = Jul 1996 | pmid = 8713116 | doi = 10.1006/bbrc.1996.1093 }}
*{{cite journal | author=Komalavilas P, Lincoln TM |title=Phosphorylation of the inositol 1,4,5-trisphosphate receptor by cyclic GMP-dependent protein kinase. |journal=J. Biol. Chem. |volume=269 |issue= 12 |pages= 8701–7 |year= 1994 |pmid= 8132598 |doi= }}
* {{cite journal | vauthors = Cameron AM, Nucifora FC, Fung ET, Livingston DJ, Aldape RA, Ross CA, Snyder SH | title = FKBP12 binds the inositol 1,4,5-trisphosphate receptor at leucine-proline (1400-1401) and anchors calcineurin to this FK506-like domain | journal = The Journal of Biological Chemistry | volume = 272 | issue = 44 | pages = 27582–8 | date = Oct 1997 | pmid = 9346894 | doi = 10.1074/jbc.272.44.27582 }}
*{{cite journal | author=Cameron AM, Steiner JP, Roskams AJ, ''et al.'' |title=Calcineurin associated with the inositol 1,4,5-trisphosphate receptor-FKBP12 complex modulates Ca2+ flux. |journal=Cell |volume=83 |issue= 3 |pages= 463–72 |year= 1996 |pmid= 8521476 |doi= }}
* {{cite journal | vauthors = Deelman LE, Jonk LJ, Henning RH | title = The isolation and characterization of the promoter of the human type 1 inositol 1,4,5-trisphosphate receptor | journal = Gene | volume = 207 | issue = 2 | pages = 219–25 | date = Jan 1998 | pmid = 9511764 | doi = 10.1016/S0378-1119(97)00630-6 }}
*{{cite journal | author=Yan J, Khanna KK, Lavin MF |title=Induction of inositol 1,4,5 trisphosphate receptor genes by ionizing radiation. |journal=Int. J. Radiat. Biol. |volume=69 |issue= 5 |pages= 539–46 |year= 1996 |pmid= 8648241 |doi= }}
* {{cite journal | vauthors = Martin C, Chapman KE, Seckl JR, Ashley RH | title = Partial cloning and differential expression of ryanodine receptor/calcium-release channel genes in human tissues including the hippocampus and cerebellum | journal = Neuroscience | volume = 85 | issue = 1 | pages = 205–16 | date = Jul 1998 | pmid = 9607712 | doi = 10.1016/S0306-4522(97)00612-X }}
*{{cite journal | author=Quinton TM, Dean WL |title=Multiple inositol 1,4,5-trisphosphate receptor isoforms are present in platelets. |journal=Biochem. Biophys. Res. Commun. |volume=224 |issue= 3 |pages= 740–6 |year= 1996 |pmid= 8713116 |doi= 10.1006/bbrc.1996.1093 }}
* {{cite journal | vauthors = Tu JC, Xiao B, Yuan JP, Lanahan AA, Leoffert K, Li M, Linden DJ, Worley PF | title = Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors | journal = Neuron | volume = 21 | issue = 4 | pages = 717–26 | date = Oct 1998 | pmid = 9808459 | doi = 10.1016/S0896-6273(00)80589-9 }}
*{{cite journal | author=Cameron AM, Nucifora FC, Fung ET, ''et al.'' |title=FKBP12 binds the inositol 1,4,5-trisphosphate receptor at leucine-proline (1400-1401) and anchors calcineurin to this FK506-like domain. |journal=J. Biol. Chem. |volume=272 |issue= 44 |pages= 27582–8 |year= 1997 |pmid= 9346894 |doi= }}
* {{cite journal | vauthors = Kiselyov K, Xu X, Mozhayeva G, Kuo T, Pessah I, Mignery G, Zhu X, Birnbaumer L, Muallem S | title = Functional interaction between InsP3 receptors and store-operated Htrp3 channels | journal = Nature | volume = 396 | issue = 6710 | pages = 478–82 | date = Dec 1998 | pmid = 9853757 | doi = 10.1038/24890 }}
*{{cite journal | author=Deelman LE, Jonk LJ, Henning RH |title=The isolation and characterization of the promoter of the human type 1 inositol 1,4,5-trisphosphate receptor. |journal=Gene |volume=207 |issue= 2 |pages= 219–25 |year= 1998 |pmid= 9511764 |doi= }}
* {{cite journal | vauthors = Lin P, Yao Y, Hofmeister R, Tsien RY, Farquhar MG | title = Overexpression of CALNUC (nucleobindin) increases agonist and thapsigargin releasable Ca2+ storage in the Golgi | journal = The Journal of Cell Biology | volume = 145 | issue = 2 | pages = 279–89 | date = Apr 1999 | pmid = 10209024 | pmc = 2133108 | doi = 10.1083/jcb.145.2.279 }}
*{{cite journal | author=Martin C, Chapman KE, Seckl JR, Ashley RH |title=Partial cloning and differential expression of ryanodine receptor/calcium-release channel genes in human tissues including the hippocampus and cerebellum. |journal=Neuroscience |volume=85 |issue= 1 |pages= 205–16 |year= 1998 |pmid= 9607712 |doi= }}
* {{cite journal | vauthors = Schlossmann J, Ammendola A, Ashman K, Zong X, Huber A, Neubauer G, Wang GX, Allescher HD, Korth M, Wilm M, Hofmann F, Ruth P | title = Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase Ibeta | journal = Nature | volume = 404 | issue = 6774 | pages = 197–201 | date = Mar 2000 | pmid = 10724174 | doi = 10.1038/35004606 }}
*{{cite journal | author=Tu JC, Xiao B, Yuan JP, ''et al.'' |title=Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors. |journal=Neuron |volume=21 |issue= 4 |pages= 717–26 |year= 1998 |pmid= 9808459 |doi= }}
* {{cite journal | vauthors = Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, Zago MA, Bordin S, Costa FF, Goldman GH, Carvalho AF, Matsukuma A, Baia GS, Simpson DH, Brunstein A, de Oliveira PS, Bucher P, Jongeneel CV, O'Hare MJ, Soares F, Brentani RR, Reis LF, de Souza SJ, Simpson AJ | title = Shotgun sequencing of the human transcriptome with ORF expressed sequence tags | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 97 | issue = 7 | pages = 3491–6 | date = Mar 2000 | pmid = 10737800 | pmc = 16267 | doi = 10.1073/pnas.97.7.3491 }}
*{{cite journal | author=Kiselyov K, Xu X, Mozhayeva G, ''et al.'' |title=Functional interaction between InsP3 receptors and store-operated Htrp3 channels. |journal=Nature |volume=396 |issue= 6710 |pages= 478–82 |year= 1998 |pmid= 9853757 |doi= 10.1038/24890 }}
* {{cite journal | vauthors = Mayne M, Holden CP, Nath A, Geiger JD | title = Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages | journal = Journal of Immunology | volume = 164 | issue = 12 | pages = 6538–42 | date = Jun 2000 | pmid = 10843712 | doi = 10.4049/jimmunol.164.12.6538 }}
*{{cite journal | author=Lin P, Yao Y, Hofmeister R, ''et al.'' |title=Overexpression of CALNUC (nucleobindin) increases agonist and thapsigargin releasable Ca2+ storage in the Golgi. |journal=J. Cell Biol. |volume=145 |issue= 2 |pages= 279–89 |year= 1999 |pmid= 10209024 |doi= }}
* {{cite journal | vauthors = Tanimura A, Tojyo Y, Turner RJ | title = Evidence that type I, II, and III inositol 1,4,5-trisphosphate receptors can occur as integral plasma membrane proteins | journal = The Journal of Biological Chemistry | volume = 275 | issue = 35 | pages = 27488–93 | date = Sep 2000 | pmid = 10874040 | doi = 10.1074/jbc.M004495200 }}
*{{cite journal | author=Schlossmann J, Ammendola A, Ashman K, ''et al.'' |title=Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase Ibeta. |journal=Nature |volume=404 |issue= 6774 |pages= 197–201 |year= 2000 |pmid= 10724174 |doi= 10.1038/35004606 }}
*{{cite journal | author=Dias Neto E, Correa RG, Verjovski-Almeida S, ''et al.'' |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491–6 |year= 2000 |pmid= 10737800 |doi=  }}
*{{cite journal  | author=Mayne M, Holden CP, Nath A, Geiger JD |title=Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages. |journal=J. Immunol. |volume=164 |issue= 12 |pages= 6538–42 |year= 2000 |pmid= 10843712 |doi=  }}
*{{cite journal  | author=Tanimura A, Tojyo Y, Turner RJ |title=Evidence that type I, II, and III inositol 1,4,5-trisphosphate receptors can occur as integral plasma membrane proteins. |journal=J. Biol. Chem. |volume=275 |issue= 35 |pages= 27488–93 |year= 2000 |pmid= 10874040 |doi= 10.1074/jbc.M004495200 }}
}}
{{refend}}
{{refend}}


== External links ==
== External links ==
* {{MeshName|ITPR1+protein,+human}}
* {{MeshName|ITPR1+protein,+human}}
* [https://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=sca15  GeneReviews/NCBI/NIH/UW entry on Spinocerebellar Ataxia Type 15]


 
{{PDB Gallery|geneid=3708}}
{{Ion channels}}
{{Ion channels|g1}}


[[Category:Ion channels]]
[[Category:Ion channels]]
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Latest revision as of 00:13, 1 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Inositol 1,4,5-trisphosphate receptor type 1 is a protein that in humans is encoded by the ITPR1 gene.[1][2][3][4][5]

Interactions

ITPR1 has been shown to interact with:

See also

References

  1. ↑ Yamada N, Makino Y, Clark RA, Pearson DW, Mattei MG, Guénet JL, Ohama E, Fujino I, Miyawaki A, Furuichi T (Sep 1994). "Human inositol 1,4,5-trisphosphate type-1 receptor, InsP3R1: structure, function, regulation of expression and chromosomal localization". The Biochemical Journal. 302 (Pt 3): 781–90. doi:10.1042/bj3020781. PMC 1137299. PMID 7945203.
  2. ↑ Nucifora FC, Li SH, Danoff S, Ullrich A, Ross CA (Sep 1995). "Molecular cloning of a cDNA for the human inositol 1,4,5-trisphosphate receptor type 1, and the identification of a third alternatively spliced variant". Brain Research. Molecular Brain Research. 32 (2): 291–6. doi:10.1016/0169-328X(95)00089-B. PMID 7500840.
  3. ↑ van de Leemput J, Chandran J, Knight MA, Holtzclaw LA, Scholz S, Cookson MR, Houlden H, Gwinn-Hardy K, Fung HC, Lin X, Hernandez D, Simon-Sanchez J, Wood NW, Giunti P, Rafferty I, Hardy J, Storey E, Gardner RJ, Forrest SM, Fisher EM, Russell JT, Cai H, Singleton AB (Jun 2007). "Deletion at ITPR1 underlies ataxia in mice and spinocerebellar ataxia 15 in humans". PLoS Genetics. 3 (6): e108. doi:10.1371/journal.pgen.0030108. PMC 1892049. PMID 17590087.
  4. ↑ Iwaki A, Kawano Y, Miura S, Shibata H, Matsuse D, Li W, Furuya H, Ohyagi Y, Taniwaki T, Kira J, Fukumaki Y (Jan 2008). "Heterozygous deletion of ITPR1, but not SUMF1, in spinocerebellar ataxia type 16". Journal of Medical Genetics. 45 (1): 32–5. doi:10.1136/jmg.2007.053942. PMID 17932120.
  5. ↑ "Entrez Gene: ITPR1 inositol 1,4,5-triphosphate receptor, type 1".
  6. ↑ Ando H, Mizutani A, Matsu-ura T, Mikoshiba K (Mar 2003). "IRBIT, a novel inositol 1,4,5-trisphosphate (IP3) receptor-binding protein, is released from the IP3 receptor upon IP3 binding to the receptor". The Journal of Biological Chemistry. 278 (12): 10602–12. doi:10.1074/jbc.M210119200. PMID 12525476.
  7. ↑ Hirota J, Ando H, Hamada K, Mikoshiba K (Jun 2003). "Carbonic anhydrase-related protein is a novel binding protein for inositol 1,4,5-trisphosphate receptor type 1". The Biochemical Journal. 372 (Pt 2): 435–41. doi:10.1042/BJ20030110. PMC 1223404. PMID 12611586.
  8. ↑ Maximov A, Tang TS, Bezprozvanny I (Feb 2003). "Association of the type 1 inositol (1,4,5)-trisphosphate receptor with 4.1N protein in neurons". Molecular and Cellular Neurosciences. 22 (2): 271–83. doi:10.1016/s1044-7431(02)00027-1. PMID 12676536.
  9. ↑ MacMillan D, Currie S, Bradley KN, Muir TC, McCarron JG (Dec 2005). "In smooth muscle, FK506-binding protein modulates IP3 receptor-evoked Ca2+ release by mTOR and calcineurin". Journal of Cell Science. 118 (Pt 23): 5443–51. doi:10.1242/jcs.02657. PMID 16278292.
  10. ↑ Cameron AM, Nucifora FC, Fung ET, Livingston DJ, Aldape RA, Ross CA, Snyder SH (Oct 1997). "FKBP12 binds the inositol 1,4,5-trisphosphate receptor at leucine-proline (1400-1401) and anchors calcineurin to this FK506-like domain". The Journal of Biological Chemistry. 272 (44): 27582–8. doi:10.1074/jbc.272.44.27582. PMID 9346894.
  11. ↑ 11.0 11.1 Schlossmann J, Ammendola A, Ashman K, Zong X, Huber A, Neubauer G, Wang GX, Allescher HD, Korth M, Wilm M, Hofmann F, Ruth P (Mar 2000). "Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase Ibeta". Nature. 404 (6774): 197–201. doi:10.1038/35004606. PMID 10724174.
  12. ↑ Mehta D, Ahmmed GU, Paria BC, Holinstat M, Voyno-Yasenetskaya T, Tiruppathi C, Minshall RD, Malik AB (Aug 2003). "RhoA interaction with inositol 1,4,5-trisphosphate receptor and transient receptor potential channel-1 regulates Ca2+ entry. Role in signaling increased endothelial permeability". The Journal of Biological Chemistry. 278 (35): 33492–500. doi:10.1074/jbc.M302401200. PMID 12766172.
  13. ↑ Yuan JP, Kiselyov K, Shin DM, Chen J, Shcheynikov N, Kang SH, Dehoff MH, Schwarz MK, Seeburg PH, Muallem S, Worley PF (Sep 2003). "Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors". Cell. 114 (6): 777–89. doi:10.1016/s0092-8674(03)00716-5. PMID 14505576.
  14. ↑ Mery L, Magnino F, Schmidt K, Krause KH, Dufour JF (Jan 2001). "Alternative splice variants of hTrp4 differentially interact with the C-terminal portion of the inositol 1,4,5-trisphosphate receptors". FEBS Letters. 487 (3): 377–83. doi:10.1016/s0014-5793(00)02362-0. PMID 11163362.

Further reading

  • Stove V, Verhasselt B (Jan 2006). "Modelling thymic HIV-1 Nef effects". Current HIV Research. 4 (1): 57–64. doi:10.2174/157016206775197583. PMID 16454711.
  • Joseph SK, Lin C, Pierson S, Thomas AP, Maranto AR (Oct 1995). "Heteroligomers of type-I and type-III inositol trisphosphate receptors in WB rat liver epithelial cells". The Journal of Biological Chemistry. 270 (40): 23310–6. doi:10.1074/jbc.270.40.23310. PMID 7559486.
  • Harnick DJ, Jayaraman T, Ma Y, Mulieri P, Go LO, Marks AR (Feb 1995). "The human type 1 inositol 1,4,5-trisphosphate receptor from T lymphocytes. Structure, localization, and tyrosine phosphorylation". The Journal of Biological Chemistry. 270 (6): 2833–40. doi:10.1074/jbc.270.6.2833. PMID 7852357.
  • Wojcikiewicz RJ, Furuichi T, Nakade S, Mikoshiba K, Nahorski SR (Mar 1994). "Muscarinic receptor activation down-regulates the type I inositol 1,4,5-trisphosphate receptor by accelerating its degradation". The Journal of Biological Chemistry. 269 (11): 7963–9. PMID 8132516.
  • Komalavilas P, Lincoln TM (Mar 1994). "Phosphorylation of the inositol 1,4,5-trisphosphate receptor by cyclic GMP-dependent protein kinase". The Journal of Biological Chemistry. 269 (12): 8701–7. PMID 8132598.
  • Cameron AM, Steiner JP, Roskams AJ, Ali SM, Ronnett GV, Snyder SH (Nov 1995). "Calcineurin associated with the inositol 1,4,5-trisphosphate receptor-FKBP12 complex modulates Ca2+ flux". Cell. 83 (3): 463–72. doi:10.1016/0092-8674(95)90124-8. PMID 8521476.
  • Yan J, Khanna KK, Lavin MF (May 1996). "Induction of inositol 1,4,5 trisphosphate receptor genes by ionizing radiation". International Journal of Radiation Biology. 69 (5): 539–46. doi:10.1080/095530096145544. PMID 8648241.
  • Quinton TM, Dean WL (Jul 1996). "Multiple inositol 1,4,5-trisphosphate receptor isoforms are present in platelets". Biochemical and Biophysical Research Communications. 224 (3): 740–6. doi:10.1006/bbrc.1996.1093. PMID 8713116.
  • Cameron AM, Nucifora FC, Fung ET, Livingston DJ, Aldape RA, Ross CA, Snyder SH (Oct 1997). "FKBP12 binds the inositol 1,4,5-trisphosphate receptor at leucine-proline (1400-1401) and anchors calcineurin to this FK506-like domain". The Journal of Biological Chemistry. 272 (44): 27582–8. doi:10.1074/jbc.272.44.27582. PMID 9346894.
  • Deelman LE, Jonk LJ, Henning RH (Jan 1998). "The isolation and characterization of the promoter of the human type 1 inositol 1,4,5-trisphosphate receptor". Gene. 207 (2): 219–25. doi:10.1016/S0378-1119(97)00630-6. PMID 9511764.
  • Martin C, Chapman KE, Seckl JR, Ashley RH (Jul 1998). "Partial cloning and differential expression of ryanodine receptor/calcium-release channel genes in human tissues including the hippocampus and cerebellum". Neuroscience. 85 (1): 205–16. doi:10.1016/S0306-4522(97)00612-X. PMID 9607712.
  • Tu JC, Xiao B, Yuan JP, Lanahan AA, Leoffert K, Li M, Linden DJ, Worley PF (Oct 1998). "Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors". Neuron. 21 (4): 717–26. doi:10.1016/S0896-6273(00)80589-9. PMID 9808459.
  • Kiselyov K, Xu X, Mozhayeva G, Kuo T, Pessah I, Mignery G, Zhu X, Birnbaumer L, Muallem S (Dec 1998). "Functional interaction between InsP3 receptors and store-operated Htrp3 channels". Nature. 396 (6710): 478–82. doi:10.1038/24890. PMID 9853757.
  • Lin P, Yao Y, Hofmeister R, Tsien RY, Farquhar MG (Apr 1999). "Overexpression of CALNUC (nucleobindin) increases agonist and thapsigargin releasable Ca2+ storage in the Golgi". The Journal of Cell Biology. 145 (2): 279–89. doi:10.1083/jcb.145.2.279. PMC 2133108. PMID 10209024.
  • Schlossmann J, Ammendola A, Ashman K, Zong X, Huber A, Neubauer G, Wang GX, Allescher HD, Korth M, Wilm M, Hofmann F, Ruth P (Mar 2000). "Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase Ibeta". Nature. 404 (6774): 197–201. doi:10.1038/35004606. PMID 10724174.
  • Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, Zago MA, Bordin S, Costa FF, Goldman GH, Carvalho AF, Matsukuma A, Baia GS, Simpson DH, Brunstein A, de Oliveira PS, Bucher P, Jongeneel CV, O'Hare MJ, Soares F, Brentani RR, Reis LF, de Souza SJ, Simpson AJ (Mar 2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proceedings of the National Academy of Sciences of the United States of America. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
  • Mayne M, Holden CP, Nath A, Geiger JD (Jun 2000). "Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages". Journal of Immunology. 164 (12): 6538–42. doi:10.4049/jimmunol.164.12.6538. PMID 10843712.
  • Tanimura A, Tojyo Y, Turner RJ (Sep 2000). "Evidence that type I, II, and III inositol 1,4,5-trisphosphate receptors can occur as integral plasma membrane proteins". The Journal of Biological Chemistry. 275 (35): 27488–93. doi:10.1074/jbc.M004495200. PMID 10874040.

External links

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