High density lipoprotein historical perspective: Difference between revisions
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Revision as of 12:23, 13 September 2013
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High Density Lipoprotein Microchapters |
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High density lipoprotein historical perspective On the Web |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Historical Perspective
Historically, beginning in the late 1970's cholesterol and lipid assays were promoted to estimate total HDL-cholesterol because such tests used to be far less expensive, by about 50 fold, than measured lipoprotein particle concentrations and subclass analysis. Over time, with continued research, decreasing costs, greater availability and wider acceptance of other "lipoprotein subclass analysis" assay methods, including NMR spectroscopy, human studies have continued to show a stronger correlation between human clinically obvious cardiovascular events and quantitatively measured large HDL-particle concentrations.[1]
References
- ↑ Umemoto T, Han CY, Mitra P; et al. (2013). "Apolipoprotein A-I and HDL Have Anti-Inflammatory Effects onAdipocytes via Cholesterol Transporters: ATP-Binding Cassette (ABC) A-1, ABCG-1 and Scavenger Receptor B-1(SRB-1)". Circulation Research. doi:10.1161/CIRCRESAHA.111.300581. PMID 23501697. Unknown parameter
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