High VLDL causes: Difference between revisions

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===Common Causes===
===Common Causes===
*[[Androgens]]
*[[Chronic liver disease]]
*[[Chronic liver disease]]
*[[diabetes mellitus|Diabetes mellitus type 2]]
*[[Familial hypercholesterolemia]]<ref name="Durrington-2003">{{Cite journal  | last1 = Durrington | first1 = P. | title = Dyslipidaemia. | journal = Lancet | volume = 362 | issue = 9385 | pages = 717-31 | month = Aug | year = 2003 | doi = 10.1016/S0140-6736(03)14234-1 | PMID = 12957096 }}</ref>
*[[Familial hypercholesterolemia]]<ref name="Durrington-2003">{{Cite journal  | last1 = Durrington | first1 = P. | title = Dyslipidaemia. | journal = Lancet | volume = 362 | issue = 9385 | pages = 717-31 | month = Aug | year = 2003 | doi = 10.1016/S0140-6736(03)14234-1 | PMID = 12957096 }}</ref>
*[[Saturated fat|High saturated fat diet]]<ref name="Covington-2004">{{Cite journal  | last1 = Covington | first1 = MB. | title = Omega-3 fatty acids. | journal = Am Fam Physician | volume = 70 | issue = 1 | pages = 133-40 | month = Jul | year = 2004 | doi =  | PMID = 15259529 }}</ref>
*[[Saturated fat|High saturated fat diet]]<ref name="Covington-2004">{{Cite journal  | last1 = Covington | first1 = MB. | title = Omega-3 fatty acids. | journal = Am Fam Physician | volume = 70 | issue = 1 | pages = 133-40 | month = Jul | year = 2004 | doi =  | PMID = 15259529 }}</ref>
*[[Progestagens]]


===Causes by Organ System===
===Causes by Organ System===
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| '''Endocrine'''
| '''Endocrine'''
|bgcolor="Beige"| [[Androgens]], [[dehydroepiandrosterone]], [[growth hormone deficiency]], [[hypercortisolism]], [[hypothyroidism]], [[polycystic ovarian syndrome]], [[progestagens]], [[Hypothyroidism|subclinical hypothyroidism]], [[testosterone]]
|bgcolor="Beige"| [[Androgens]], [[Cushing's syndrome]], [[dehydroepiandrosterone]], [[diabetes mellitus type 2]], [[growth hormone deficiency]], [[hypercortisolism]], [[hypothyroidism]], [[polycystic ovarian syndrome]], [[progestagens]], [[Hypothyroidism|subclinical hypothyroidism]], [[testosterone]]
|-
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| '''Genetic'''
| '''Genetic'''
|bgcolor="Beige"| [[Niemann-Pick disease|Acid sphingomyelinase deficiency]], [[apolipoprotein C2|apolipoprotein C-II deficiency]], [[Familial hypercholesterolemia|autosomal recessive hypercholesterolemia]], [[familial combined hyperlipidemia]], [[Apolipoprotein B deficiency|familial defective apolipoprotein B-100]], [[familial hypercholesterolemia]], [[familial hypertriglyceridaemia]], [[familial mixed hyperlipidaemia]], [[Hyperlipoproteinemia|familial hyperlipoproteinemia]], [[Interleukin 28#Clinical Significance|IL 28B polymorphisms]], [[lipoprotein lipase deficiency]], [[Niemann-Pick disease]], [[hypercholesterolemia|polygenic hypercholesterolemia]], type 5]]
|bgcolor="Beige"| [[Niemann-Pick disease|Acid sphingomyelinase deficiency]], [[apolipoprotein C2|apolipoprotein C-II deficiency]], [[Familial hypercholesterolemia|autosomal recessive hypercholesterolemia]], [[familial combined hyperlipidemia]], [[Apolipoprotein B deficiency|familial defective apolipoprotein B-100]], [[familial hypercholesterolemia]], [[familial hypertriglyceridaemia]], [[familial mixed hyperlipidaemia]], [[Hyperlipoproteinemia|familial hyperlipoproteinemia type 5]], [[Interleukin 28#Clinical Significance|IL 28B polymorphisms]], [[lipoprotein lipase deficiency]], [[Niemann-Pick disease]], [[hypercholesterolemia|polygenic hypercholesterolemia]]
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| '''Infectious Disease'''
| '''Infectious Disease'''
|bgcolor="Beige"| [[Gram negative bacteremia]], [[H. pylori]],  [[small bowel bacterial overgrowth syndrome]],
|bgcolor="Beige"| [[Gram negative bacteremia|gram negative sepsis]], [[H. pylori infection]],  [[small bowel bacterial overgrowth syndrome]],
|-
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Revision as of 16:02, 25 September 2013

Very Low Density Lipoprotein Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mugilan Poongkunran M.B.B.S [2]

Overview

High VLDL may primarily be a consequence of inherited (genetic) diseases that affect the lipid metabolism, or due to secondary causes other than the primary inherited disorders of lipid metabolism.

Causes

Life Threatening Causes

Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated.

Common Causes

Causes by Organ System

Cardiovascular No underlying causes
Chemical/Poisoning Diterpenoids
Dental No underlying causes
Dermatologic No underlying causes
Drug Side Effect Atazanavir, azathioprine, bexarotene, calcineurin inhibitors, chlortalidone, corticosteroids, cyclosporine, desvenlafaxine, fish oil supplements, immunosuppressive agents, levonorgestrel, lopinavir, mycophenolate, nicotine, norgestrel, prednisone, progestin, rapamycin, rosiglitazone, sirolimus, thiazide, tocilizumab
Ear Nose Throat No underlying causes
Endocrine Androgens, Cushing's syndrome, dehydroepiandrosterone, diabetes mellitus type 2, growth hormone deficiency, hypercortisolism, hypothyroidism, polycystic ovarian syndrome, progestagens, subclinical hypothyroidism, testosterone
Environmental No underlying causes
Gastroenterologic No underlying causes
Genetic Acid sphingomyelinase deficiency, apolipoprotein C-II deficiency, autosomal recessive hypercholesterolemia, familial combined hyperlipidemia, familial defective apolipoprotein B-100, familial hypercholesterolemia, familial hypertriglyceridaemia, familial mixed hyperlipidaemia, familial hyperlipoproteinemia type 5, IL 28B polymorphisms, lipoprotein lipase deficiency, Niemann-Pick disease, polygenic hypercholesterolemia
Hematologic No underlying causes
Iatrogenic No underlying causes
Infectious Disease gram negative sepsis, H. pylori infection, small bowel bacterial overgrowth syndrome,
Musculoskeletal/Orthopedic No underlying causes
Neurologic No underlying causes
Nutritional/Metabolic Chenodeoxycholic acid, high carbohydrate diet, high saturated fat diet, omega-3 polyunsaturated fatty acids, polygenic hypercholesterolemia, primary hyperlipoproteinemia, primary hypolipoproteinemia, selenium deficiency
Obstetric/Gynecologic Polycystic ovarian syndrome
Oncologic No underlying causes
Ophthalmologic No underlying causes
Overdose/Toxicity No underlying causes
Psychiatric No underlying causes
Pulmonary No underlying causes
Renal/Electrolyte Chronic kidney disease, nephrotic syndrome
Rheumatology/Immunology/Allergy Dysproteinemia, lipopolysaccharides, monoclonal gammopathy, paraproteinemia
Sexual No underlying causes
Trauma No underlying causes
Urologic No underlying causes
Miscellaneous No underlying causes

Causes in Alphabetical Order

References

  1. 1.0 1.1 Durrington, P. (2003). "Dyslipidaemia". Lancet. 362 (9385): 717–31. doi:10.1016/S0140-6736(03)14234-1. PMID 12957096. Unknown parameter |month= ignored (help)
  2. 2.0 2.1 Covington, MB. (2004). "Omega-3 fatty acids". Am Fam Physician. 70 (1): 133–40. PMID 15259529. Unknown parameter |month= ignored (help)
  3. Pejic, RN.; Lee, DT. "Hypertriglyceridemia". J Am Board Fam Med. 19 (3): 310–6. PMID 16672684.
  4. Kronenberg, F. (2005). "Dyslipidemia and nephrotic syndrome: recent advances". J Ren Nutr. 15 (2): 195–203. PMID 15827892. Unknown parameter |month= ignored (help)


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