High VLDL causes

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Very Low Density Lipoprotein Microchapters


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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mugilan Poongkunran M.B.B.S [2]


High VLDL may be a consequence of inherited diseases that affect the lipid metabolism, or cab be due to secondary causes such as drugs and chronic liver disease.


Life Threatening Causes

Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated.

Common Causes

Causes by Organ System

Cardiovascular No underlying causes
Chemical/Poisoning Diterpenoids
Dental No underlying causes
Dermatologic No underlying causes
Drug Side Effect Azathioprine, bexarotene, calcineurin inhibitors, chlortalidone, corticosteroids, cyclosporine, desvenlafaxine, immunosuppressive agents, levonorgestrel, lopinavir, mycophenolate, nicotine, norgestrel, prednisone, progestin, protease inhibitors, rapamycin, rosiglitazone, sirolimus, thiazide, tocilizumab
Ear Nose Throat No underlying causes
Endocrine Acromegaly, Cushing's syndrome, dehydroepiandrosterone, diabetes mellitus type 2, hypercortisolism, hypothyroidism, polycystic ovarian syndrome, subclinical hypothyroidism
Environmental No underlying causes
Gastroenterologic Acute hepatitis, chronic liver disease, obstructive jaundice
Genetic Acid sphingomyelinase deficiency, apolipoprotein C-II deficiency, autosomal recessive hypercholesterolemia, familial combined hyperlipidemia, familial defective apolipoprotein B-100, familial hypercholesterolemia, familial hyperlipoproteinemia type 5, familial hypertriglyceridaemia, familial mixed hyperlipidaemia, IL 28B polymorphisms, lipoprotein lipase deficiency, Niemann-Pick disease, polygenic hypercholesterolemia
Hematologic No underlying causes
Iatrogenic No underlying causes
Infectious Disease Gram negative sepsis, H. pylori infection, small bowel bacterial overgrowth syndrome
Musculoskeletal/Orthopedic No underlying causes
Neurologic No underlying causes
Nutritional/Metabolic Chenodeoxycholic acid, high carbohydrate diet, high saturated fat diet, polygenic hypercholesterolemia, primary hyperlipoproteinemia, primary hypolipoproteinemia, selenium deficiency
Obstetric/Gynecologic Polycystic ovarian syndrome
Oncologic Lymphoma, multiple myeloma
Ophthalmologic No underlying causes
Overdose/Toxicity No underlying causes
Psychiatric No underlying causes
Pulmonary No underlying causes
Renal/Electrolyte Chronic kidney disease, nephrotic syndrome, uremia
Rheumatology/Immunology/Allergy Dysproteinemia, monoclonal gammopathy, multiple myeloma, paraproteinemia
Sexual No underlying causes
Trauma No underlying causes
Urologic No underlying causes
Miscellaneous Alcoholism

Causes in Alphabetical Order


  1. 1.0 1.1 Durrington, P. (2003). "Dyslipidaemia". Lancet. 362 (9385): 717–31. doi:10.1016/S0140-6736(03)14234-1. PMID 12957096. Unknown parameter |month= ignored (help)
  2. 2.0 2.1 Covington, MB. (2004). "Omega-3 fatty acids". Am Fam Physician. 70 (1): 133–40. PMID 15259529. Unknown parameter |month= ignored (help)
  3. Kronenberg, F. (2005). "Dyslipidemia and nephrotic syndrome: recent advances". J Ren Nutr. 15 (2): 195–203. PMID 15827892. Unknown parameter |month= ignored (help)

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