Fatigue in children: Difference between revisions
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==Overview== | ==Overview== | ||
[[Fatigue]] is a symptom defined by a subjective sense of increased more than average [[tiredness]] and exhaustion after a routine task that impairs one’s physical and mental capabilities<ref name="pmid20456309">{{cite journal| author=van Langenberg DR, Gibson PR| title=Systematic review: fatigue in inflammatory bowel disease. | journal=Aliment Pharmacol Ther | year= 2010 | volume= 32 | issue= 2 | pages= 131-43 | pmid=20456309 | doi=10.1111/j.1365-2036.2010.04347.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20456309 }} </ref>. The [[chronic fatigue syndrome]] is defined as severe persistent debilitating [[fatigue]] for six months or more along with somatic symptoms like [[myalgia]], [[headache]], [[joint pain]] and [[sore throat]]<ref name="pmid7978722">{{cite journal| author=Fukuda K, Straus SE, Hickie I, Sharpe MC, Dobbins JG, Komaroff A| title=The chronic fatigue syndrome: a comprehensive approach to its definition and study. International Chronic Fatigue Syndrome Study Group. | journal=Ann Intern Med | year= 1994 | volume= 121 | issue= 12 | pages= 953-9 | pmid=7978722 | doi=10.7326/0003-4819-121-12-199412150-00009 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7978722 }} </ref>. The incidence of [[fatigue]] is high in children particularly in [[adolescence]] due to high education and psychosocial stress<ref name="pmid16740810">{{cite journal| author=ter Wolbeek M, van Doornen LJ, Kavelaars A, Heijnen CJ| title=Severe fatigue in adolescents: a common phenomenon? | journal=Pediatrics | year= 2006 | volume= 117 | issue= 6 | pages= e1078-86 | pmid=16740810 | doi=10.1542/peds.2005-2575 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16740810 }} </ref>. It can have severe debilating adverse effects on [[children]] and negatively impact their academic and social life.The [[fatigue]] can also be a symptom of an underlying [[disease]]. Hence, a thorough clinical evaluation and relevant investigations should be performed to rule out any underlying [[pathology]]. | |||
==Classification== | ==Classification== | ||
* | * There is no known classification of [[fatigue]] in [[children]]. | ||
==Pathophysiology== | ==Pathophysiology== | ||
*The pathogenesis of [ | *The pathogenesis of [[fatigue]] in [[children]] is unknown and it depends upon the underlying [[disease]]. | ||
* | *It is characterized by impaired [[humoral]] and [[cellular immunity]] with a reduced response by [[natural killer cell]]s and [[lymphocyte]]s in response to various [[viral]] [[infection]]s<ref name="pmid8491097">{{cite journal| author=Lloyd AR, Wakefield D, Hickie I| title=Immunity and the pathophysiology of chronic fatigue syndrome. | journal=Ciba Found Symp | year= 1993 | volume= 173 | issue= | pages= 176-87; discussion 187-92 | pmid=8491097 | doi=10.1002/9780470514382.ch11 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8491097 }} </ref>. | ||
*A reduced level of the total [[immunoglobulins]] G and its various subclasses have also been documented. | |||
* | |||
==Causes== | ==Causes== | ||
| Line 49: | Line 38: | ||
* Strained family relations | * Strained family relations | ||
==Differentiating [ | ==Differentiating [[fatigue]] from other Diseases== | ||
Chronic [[fatigue]] in children should be differentiated from other symptoms that result in extreme [[tiredness]] like [[sleeplessness]] and [[muscle weakness]]<ref name="pmid19389615">{{cite journal| author=Nutini M, Karczewski M, Capoor J| title=Fatigue in children with neurologic impairments. | journal=Phys Med Rehabil Clin N Am | year= 2009 | volume= 20 | issue= 2 | pages= 339-46 | pmid=19389615 | doi=10.1016/j.pmr.2008.12.004 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19389615 }} </ref>. | |||
These symptoms can be differentiated by thorough examination of the [[patient]]. The symptoms of [[tiredness]] due to [[sleeplessness]] are alleviated by adequate [[sleep]] and adjusting sleep wake cycle<ref name="pmid16376590">{{cite journal| author=Shen J, Barbera J, Shapiro CM| title=Distinguishing sleepiness and fatigue: focus on definition and measurement. | journal=Sleep Med Rev | year= 2006 | volume= 10 | issue= 1 | pages= 63-76 | pmid=16376590 | doi=10.1016/j.smrv.2005.05.004 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16376590 }} </ref>. The [[muscle weakness]] is mainly due to underlying [[pathogy]] at the [[neuromuscular junction]]. It is tested by detailed [[neurological examination]] assessing [[muscle]] motor strength testing<ref name="pmid19389615">{{cite journal| author=Nutini M, Karczewski M, Capoor J| title=Fatigue in children with neurologic impairments. | journal=Phys Med Rehabil Clin N Am | year= 2009 | volume= 20 | issue= 2 | pages= 339-46 | pmid=19389615 | doi=10.1016/j.pmr.2008.12.004 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19389615 }} </ref>. | |||
==Epidemiology and Demographics== | ==Epidemiology and Demographics== | ||
The prevalence of [[fatigue]] in children is approximately 59,000 to 386,000 per 100,000 individuals in terminal [[cancer]]. | The prevalence of [[fatigue]] in [[children]] is approximately 59,000 to 386,000 per 100,000 individuals in terminal [[cancer]]. | ||
===Age=== | ===Age=== | ||
* The prevalence of [[fatigue]] increases with age. The [[fatigue]] commonly affects children during childhood, school, and adolescent years<ref name="pmid15781924">{{cite journal| author=Haines LC, Saidi G, Cooke RW| title=Prevalence of severe fatigue in primary care. | journal=Arch Dis Child | year= 2005 | volume= 90 | issue= 4 | pages= 367-8 | pmid=15781924 | doi=10.1136/adc.2003.039917 | pmc=1720362 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15781924 }} </ref>. | * The prevalence of [[fatigue]] increases with age. The [[fatigue]] commonly affects [[children]] during [[childhood]], school, and [[adolescent]] years<ref name="pmid15781924">{{cite journal| author=Haines LC, Saidi G, Cooke RW| title=Prevalence of severe fatigue in primary care. | journal=Arch Dis Child | year= 2005 | volume= 90 | issue= 4 | pages= 367-8 | pmid=15781924 | doi=10.1136/adc.2003.039917 | pmc=1720362 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15781924 }} </ref>. | ||
* The peak age of prevalence is 15 years. The prevalence than decreases exponentially in boys while it remains high in girls till 18 years of age<ref name="pmid15781924">{{cite journal| author=Haines LC, Saidi G, Cooke RW| title=Prevalence of severe fatigue in primary care. | journal=Arch Dis Child | year= 2005 | volume= 90 | issue= 4 | pages= 367-8 | pmid=15781924 | doi=10.1136/adc.2003.039917 | pmc=1720362 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15781924 }} </ref>.. | * The peak age of prevalence is 15 years. The prevalence than decreases exponentially in boys while it remains high in girls till 18 years of age<ref name="pmid15781924">{{cite journal| author=Haines LC, Saidi G, Cooke RW| title=Prevalence of severe fatigue in primary care. | journal=Arch Dis Child | year= 2005 | volume= 90 | issue= 4 | pages= 367-8 | pmid=15781924 | doi=10.1136/adc.2003.039917 | pmc=1720362 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15781924 }} </ref>.. | ||
| Line 68: | Line 58: | ||
===Race=== | ===Race=== | ||
There is no racial predilection for [[fatigue]] in children. | There is no racial predilection for [[fatigue]] in [[children]]. | ||
==Risk Factors== | ==Risk Factors== | ||
| Line 77: | Line 67: | ||
*Early clinical features include [[headache]], [[myalgia]], [[joint pain]], increased [[body]] [[temperature]], more [[tiredness]] thn normal after doing physical exertion<ref name="pmid15581533">{{cite journal| author=Mears CJ, Taylor RR, Jordan KM, Binns HJ, Pediatric Practice Research Group| title=Sociodemographic and symptom correlates of fatigue in an adolescent primary care sample. | journal=J Adolesc Health | year= 2004 | volume= 35 | issue= 6 | pages= 528e.21-6 | pmid=15581533 | doi=10.1016/j.jadohealth.2004.02.012 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15581533 }} </ref>. | *Early clinical features include [[headache]], [[myalgia]], [[joint pain]], increased [[body]] [[temperature]], more [[tiredness]] thn normal after doing physical exertion<ref name="pmid15581533">{{cite journal| author=Mears CJ, Taylor RR, Jordan KM, Binns HJ, Pediatric Practice Research Group| title=Sociodemographic and symptom correlates of fatigue in an adolescent primary care sample. | journal=J Adolesc Health | year= 2004 | volume= 35 | issue= 6 | pages= 528e.21-6 | pmid=15581533 | doi=10.1016/j.jadohealth.2004.02.012 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15581533 }} </ref>. | ||
*If left untreated, 20.5% of patients with [[fatigue]] in children may progress to develop [[depression]], [[mood disorder]]s, increase absence from school, and poor academic performance<ref name="pmid7838632">{{cite journal| author=Carter BD, Edwards JF, Kronenberger WG, Michalczyk L, Marshall GS| title=Case control study of chronic fatigue in pediatric patients. | journal=Pediatrics | year= 1995 | volume= 95 | issue= 2 | pages= 179-86 | pmid=7838632 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7838632 }} </ref>. | *If left untreated, 20.5% of patients with [[fatigue]] in [[children]] may progress to develop [[depression]], [[mood disorder]]s, increase absence from school, and poor academic performance<ref name="pmid7838632">{{cite journal| author=Carter BD, Edwards JF, Kronenberger WG, Michalczyk L, Marshall GS| title=Case control study of chronic fatigue in pediatric patients. | journal=Pediatrics | year= 1995 | volume= 95 | issue= 2 | pages= 179-86 | pmid=7838632 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7838632 }} </ref>. | ||
* | *Prognosis is generally good with the resolution of symptoms in 46.6% of [[patient]]s after four to six months<ref name="pmid17332180">{{cite journal| author=Rimes KA, Goodman R, Hotopf M, Wessely S, Meltzer H, Chalder T| title=Incidence, prognosis, and risk factors for fatigue and chronic fatigue syndrome in adolescents: a prospective community study. | journal=Pediatrics | year= 2007 | volume= 119 | issue= 3 | pages= e603-9 | pmid=17332180 | doi=10.1542/peds.2006-2231 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17332180 }} </ref>. | ||
==Diagnosis== | ==Diagnosis== | ||
| Line 86: | Line 75: | ||
* The diagnosis of [[chronic fatigue syndrome]] is based on the [[Centers for Disease Control and Prevention]] criteria<ref name="pmid7978722">{{cite journal| author=Fukuda K, Straus SE, Hickie I, Sharpe MC, Dobbins JG, Komaroff A| title=The chronic fatigue syndrome: a comprehensive approach to its definition and study. International Chronic Fatigue Syndrome Study Group. | journal=Ann Intern Med | year= 1994 | volume= 121 | issue= 12 | pages= 953-9 | pmid=7978722 | doi=10.7326/0003-4819-121-12-199412150-00009 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7978722 }} </ref>. | * The diagnosis of [[chronic fatigue syndrome]] is based on the [[Centers for Disease Control and Prevention]] criteria<ref name="pmid7978722">{{cite journal| author=Fukuda K, Straus SE, Hickie I, Sharpe MC, Dobbins JG, Komaroff A| title=The chronic fatigue syndrome: a comprehensive approach to its definition and study. International Chronic Fatigue Syndrome Study Group. | journal=Ann Intern Med | year= 1994 | volume= 121 | issue= 12 | pages= 953-9 | pmid=7978722 | doi=10.7326/0003-4819-121-12-199412150-00009 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7978722 }} </ref>. | ||
* The diagnosis of [[chronic fatigue syndrome]] is made when at least four of the following eight diagnostic criteria are met and symptoms are present for more than 6 months: | * The diagnosis of [[chronic fatigue syndrome]] is made when at least four of the following eight diagnostic criteria are met and symptoms are present for more than 6 months: | ||
* Impaired [[memory]] or [[concentration]] | :* Impaired [[memory]] or [[concentration]] | ||
* [[Sore throat]] | :* [[Sore throat]] | ||
* Painful [[cervical]] or [[axillary]] [[lymph nodes]] | :* Painful [[cervical]] or [[axillary]] [[lymph nodes]] | ||
* [[Myalgia]] | :* [[Myalgia]] | ||
* Poly[[arthralgia]] | :* Poly[[arthralgia]] | ||
* New onset of [[headache]] | :* New onset of [[headache]] | ||
* Unrefreshing [[sleep]] | :* Unrefreshing [[sleep]] | ||
* [[Malaise]] after exertion | :* [[Malaise]] after exertion | ||
* Any underlying [[medical]] or psychiatric illness has been ruled out. | |||
===Symptoms=== | ===Symptoms=== | ||
*Symptoms of [fatigue] may include the following<ref name="pmid7978722">{{cite journal| author=Fukuda K, Straus SE, Hickie I, Sharpe MC, Dobbins JG, Komaroff A| title=The chronic fatigue syndrome: a comprehensive approach to its definition and study. International Chronic Fatigue Syndrome Study Group. | journal=Ann Intern Med | year= 1994 | volume= 121 | issue= 12 | pages= 953-9 | pmid=7978722 | doi=10.7326/0003-4819-121-12-199412150-00009 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7978722 }} </ref>: | *Symptoms of [[fatigue]] may include the following<ref name="pmid7978722">{{cite journal| author=Fukuda K, Straus SE, Hickie I, Sharpe MC, Dobbins JG, Komaroff A| title=The chronic fatigue syndrome: a comprehensive approach to its definition and study. International Chronic Fatigue Syndrome Study Group. | journal=Ann Intern Med | year= 1994 | volume= 121 | issue= 12 | pages= 953-9 | pmid=7978722 | doi=10.7326/0003-4819-121-12-199412150-00009 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7978722 }} </ref>: | ||
:* Extreme tiredness more than normal for more than one month. | :* Extreme tiredness more than normal for more than one month. | ||
| Line 103: | Line 93: | ||
:* A detailed medical and psychiatric history should be asked to look for underlying [[disease]] or psychiatric illness. | :* A detailed medical and psychiatric history should be asked to look for underlying [[disease]] or psychiatric illness. | ||
:* Systematic symptoms like [[breathlessness]], new-onset [[headache]], [[muscle aches]], and [[joint]] [[pain]]s. | :* Systematic symptoms like [[breathlessness]], new-onset [[headache]], [[muscle aches]], and [[joint]] [[pain]]s. | ||
:* Substance abuse, [[alcohol]] or use of over the counter medications should be asked particularly from adolescent and teenager | :* Substance abuse, [[alcohol]] or use of over-the-counter medications should be asked particularly from [[adolescent]] and teenager [[patient]]s. | ||
===Physical Examination=== | ===Physical Examination=== | ||
| Line 156: | Line 146: | ||
===Medical Therapy=== | ===Medical Therapy=== | ||
*There is no treatment for [ | *There is no proven treatment for [[fatigue]] in [[children]]; the mainstay of therapy is supportive care. | ||
*[[Cognitive-behavioral therapy]] and graded [[exercise]] [[therapy]] do not have proven efficacy for the treatment of [[fatigue]] in children. Several [[randomized controlled trial]]s have shown benefit in the symptoms of [[fatigue]]<ref name="pmid29722371">{{cite journal| author=Crawley E| title=Pediatric chronic fatigue syndrome: current perspectives. | journal=Pediatric Health Med Ther | year= 2017 | volume= 9 | issue= | pages= 27-33 | pmid=29722371 | doi=10.2147/PHMT.S126253 | pmc=5919160 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=29722371 }} </ref>. Graded [[exercise]] [[therapy]] particularly [[aerobic exercise]]s have shown improvement in [[depression]] and energy levels in [[adolescent]] patients with [[chronic fatigue syndrome]]<ref name="pmid20605858">{{cite journal| author=Gordon BA, Knapman LM, Lubitz L| title=Graduated exercise training and progressive resistance training in adolescents with chronic fatigue syndrome: a randomized controlled pilot study. | journal=Clin Rehabil | year= 2010 | volume= 24 | issue= 12 | pages= 1072-9 | pmid=20605858 | doi=10.1177/0269215510371429 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20605858 }} </ref>. | |||
* | *[[Children]] with chronic [[fatigue]] have disrupted [[sleep]] with daytime [[drowsiness]] resulting in disturbed [[cortisol]] levels. [[Patient]]s should be advised on activity management and behavioral modification with regular [[sleep]] patterns avoiding prolonged [[sleep]] hours and daytime naps. Regular [[sleep]] pattern will improve diurnal [[cortisol]] levels <ref name="pmid15813608">{{cite journal| author=Segal TY, Hindmarsh PC, Viner RM| title=Disturbed adrenal function in adolescents with chronic fatigue syndrome. | journal=J Pediatr Endocrinol Metab | year= 2005 | volume= 18 | issue= 3 | pages= 295-301 | pmid=15813608 | doi=10.1515/jpem.2005.18.3.295 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15813608 }} </ref>. | ||
*[ | *The [[patient]]s complaining of [[pain]] should be referred to specialized [[pain]] [[clinic]]s and adequate treatment should be administered. [[Amitriptyline]] is administered in gradually increased doses for the management of [[pain]] with low doses given initially. The physicians should avoid prescribing [[opiate]]s due to the high incidence of adverse reactions<ref name="pmid29722371">{{cite journal| author=Crawley E| title=Pediatric chronic fatigue syndrome: current perspectives. | journal=Pediatric Health Med Ther | year= 2017 | volume= 9 | issue= | pages= 27-33 | pmid=29722371 | doi=10.2147/PHMT.S126253 | pmc=5919160 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=29722371 }} </ref>. | ||
* | *Impaired [[cognition]] in [[patient]]s can be improved with strategies implemented to improve attention span in children. These include a conducive school environment to improve the child’s attention, frequent revisions, reducing the amount of new information a child learns in a day, and use of visual tools in learning<ref name="pmid28674681">{{cite journal| author=Rowe PC, Underhill RA, Friedman KJ, Gurwitt A, Medow MS, Schwartz MS | display-authors=etal| title=Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Diagnosis and Management in Young People: A Primer. | journal=Front Pediatr | year= 2017 | volume= 5 | issue= | pages= 121 | pmid=28674681 | doi=10.3389/fped.2017.00121 | pmc=5474682 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28674681 }} </ref><ref name="pmid21571764">{{cite journal| author=Tucker P, Haig-Ferguson A, Eaton N, Crawley E| title=What to do about attention and memory problems in children with CFS/ME: a neuropsychological approach. | journal=Clin Child Psychol Psychiatry | year= 2011 | volume= 16 | issue= 2 | pages= 215-23 | pmid=21571764 | doi=10.1177/1359104511403585 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21571764 }} </ref>. | ||
*[[Dizziness]] and [[headache]] should be treated by increasing physical activity, increase [[fluid]] intake with average of 2-3 liters per day, and high consumption of [[salt]] in some cases<ref name="pmid28674681">{{cite journal| author=Rowe PC, Underhill RA, Friedman KJ, Gurwitt A, Medow MS, Schwartz MS | display-authors=etal| title=Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Diagnosis and Management in Young People: A Primer. | journal=Front Pediatr | year= 2017 | volume= 5 | issue= | pages= 121 | pmid=28674681 | doi=10.3389/fped.2017.00121 | pmc=5474682 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28674681 }} </ref>. | |||
===Surgery=== | ===Surgery=== | ||
* | *There is no known surgery for treatment of [[fatigue]] in [[children]]. | ||
===Prevention=== | ===Prevention=== | ||
*There are no primary preventive measures available for [ | *There are no primary preventive measures available for [[fatigue]]. | ||
==References== | ==References== | ||
| Line 180: | Line 165: | ||
[[Category:Pediatrics]] | [[Category:Pediatrics]] | ||
[[Category:Primary care]] | |||
Latest revision as of 21:02, 24 February 2021
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief:
Synonyms and keywords: Fatigue in kids
Overview
Fatigue is a symptom defined by a subjective sense of increased more than average tiredness and exhaustion after a routine task that impairs one’s physical and mental capabilities[1]. The chronic fatigue syndrome is defined as severe persistent debilitating fatigue for six months or more along with somatic symptoms like myalgia, headache, joint pain and sore throat[2]. The incidence of fatigue is high in children particularly in adolescence due to high education and psychosocial stress[3]. It can have severe debilating adverse effects on children and negatively impact their academic and social life.The fatigue can also be a symptom of an underlying disease. Hence, a thorough clinical evaluation and relevant investigations should be performed to rule out any underlying pathology.
Classification
Pathophysiology
- The pathogenesis of fatigue in children is unknown and it depends upon the underlying disease.
- It is characterized by impaired humoral and cellular immunity with a reduced response by natural killer cells and lymphocytes in response to various viral infections[4].
- A reduced level of the total immunoglobulins G and its various subclasses have also been documented.
Causes
Fatigue may be caused by
- Anemia
- Congestive heart failure[5]
- Cancer[6]
- Cardiac septal defect
- Diabetes
- Obesity
- Cushing's syndrome[5]
- Inflammatory bowel disease[1]
- Multiple sclerosis[7]
- Reduced physical fitness
- Anxiety [8]
- Fibromyalgia
- Juvenile rheumatoid arthritis
- Intussusception
- Depression[8]
- Obstructive sleep apnea
- Cystic fibrosis
- Strained family relations
Differentiating fatigue from other Diseases
Chronic fatigue in children should be differentiated from other symptoms that result in extreme tiredness like sleeplessness and muscle weakness[5]. These symptoms can be differentiated by thorough examination of the patient. The symptoms of tiredness due to sleeplessness are alleviated by adequate sleep and adjusting sleep wake cycle[9]. The muscle weakness is mainly due to underlying pathogy at the neuromuscular junction. It is tested by detailed neurological examination assessing muscle motor strength testing[5].
Epidemiology and Demographics
The prevalence of fatigue in children is approximately 59,000 to 386,000 per 100,000 individuals in terminal cancer.
Age
- The prevalence of fatigue increases with age. The fatigue commonly affects children during childhood, school, and adolescent years[10].
- The peak age of prevalence is 15 years. The prevalence than decreases exponentially in boys while it remains high in girls till 18 years of age[10]..
Gender
Girls are more commonly affected by fatigue than boys. The female to male ratio is approximately 1.3 to 1.[3]
Race
There is no racial predilection for fatigue in children.
Risk Factors
- Common risk factors in the development of fatigue in children are family history of fatigue, known history of asthma, mood disorder like anxiety, depression, patient belonging to upper-middle class socioeconomic group[11][12][13].
Natural History, Complications and Prognosis
- Early clinical features include headache, myalgia, joint pain, increased body temperature, more tiredness thn normal after doing physical exertion[14].
- If left untreated, 20.5% of patients with fatigue in children may progress to develop depression, mood disorders, increase absence from school, and poor academic performance[15].
- Prognosis is generally good with the resolution of symptoms in 46.6% of patients after four to six months[13].
Diagnosis
Diagnostic Criteria
- The diagnosis of chronic fatigue syndrome is based on the Centers for Disease Control and Prevention criteria[2].
- The diagnosis of chronic fatigue syndrome is made when at least four of the following eight diagnostic criteria are met and symptoms are present for more than 6 months:
- Impaired memory or concentration
- Sore throat
- Painful cervical or axillary lymph nodes
- Myalgia
- Polyarthralgia
- New onset of headache
- Unrefreshing sleep
- Malaise after exertion
- Any underlying medical or psychiatric illness has been ruled out.
Symptoms
- Extreme tiredness more than normal for more than one month.
- Onset of fatigue along with exacerbating factors should be inquired.
- A detailed medical and psychiatric history should be asked to look for underlying disease or psychiatric illness.
- Systematic symptoms like breathlessness, new-onset headache, muscle aches, and joint pains.
- Substance abuse, alcohol or use of over-the-counter medications should be asked particularly from adolescent and teenager patients.
Physical Examination
- Physical examination may be remarkable for[2]:
- Conjunctival pallor in anemia
- Petechia and purpura in leukemia patients
- A thorough examination to rule out psychiatric or neurologic disease
- Tenderness in multiple joints and muscle in fibromyalgia and juvenile idiopathic arthritis
- Tenderness in the cervical or axillary lymph nodes
Laboratory Findings
- Laboratory findings consistent with the diagnosis of fatigue in children due to underlying diseases include[2]:
- Complete blood count with differential leukocyte count (to rule out anemia or leukemia)
- Erythrocyte sedimentation rate to rule out inflammatory disease.
- Alanine transaminase, aspartate transaminase, total albumin, globulin level and total protein levels to assess liver function.
- urine analysis, serum creatinine, blood urea nitrogen, serum calcium, phosphate and electrolytes to look for underlying renal disease.
- Serum Thyroid-stimulating hormone level to rule out thyroid disease.
- Fasting blood glucose levels to rule out diabetes.
- Specific neuroimaging and viral serologies like HBV, HCV, EBV should be done in patients with particular risk factors.
Electrocardiogram
There are no ECG findings associated with fatigue in children.
X-ray
There are no x-ray findings associated with fatigue in children.
Echocardiography or Ultrasound
There are no echocardiography/ultrasound findings associated with fatigue in children.
CT scan
There are no CT scan findings associated with fatigue in children.
MRI
There are no MRI findings associated with fatigue in children.
Other Imaging Findings
There are no other imaging findings associated with fatigue in children.
Other Diagnostic Studies
- Pediatric Quality of Life Inventory (PedsQL)
- Multidimensional Fatigue Scale (MFS)
- Fatigue Scale-Child [FS-C]
- Fatigue Scale-Adolescent [FS-A]
Treatment
Medical Therapy
- There is no proven treatment for fatigue in children; the mainstay of therapy is supportive care.
- Cognitive-behavioral therapy and graded exercise therapy do not have proven efficacy for the treatment of fatigue in children. Several randomized controlled trials have shown benefit in the symptoms of fatigue[21]. Graded exercise therapy particularly aerobic exercises have shown improvement in depression and energy levels in adolescent patients with chronic fatigue syndrome[22].
- Children with chronic fatigue have disrupted sleep with daytime drowsiness resulting in disturbed cortisol levels. Patients should be advised on activity management and behavioral modification with regular sleep patterns avoiding prolonged sleep hours and daytime naps. Regular sleep pattern will improve diurnal cortisol levels [23].
- The patients complaining of pain should be referred to specialized pain clinics and adequate treatment should be administered. Amitriptyline is administered in gradually increased doses for the management of pain with low doses given initially. The physicians should avoid prescribing opiates due to the high incidence of adverse reactions[21].
- Impaired cognition in patients can be improved with strategies implemented to improve attention span in children. These include a conducive school environment to improve the child’s attention, frequent revisions, reducing the amount of new information a child learns in a day, and use of visual tools in learning[24][25].
- Dizziness and headache should be treated by increasing physical activity, increase fluid intake with average of 2-3 liters per day, and high consumption of salt in some cases[24].
Surgery
Prevention
- There are no primary preventive measures available for fatigue.
References
- ↑ 1.0 1.1 van Langenberg DR, Gibson PR (2010). "Systematic review: fatigue in inflammatory bowel disease". Aliment Pharmacol Ther. 32 (2): 131–43. doi:10.1111/j.1365-2036.2010.04347.x. PMID 20456309.
- ↑ 2.0 2.1 2.2 2.3 2.4 Fukuda K, Straus SE, Hickie I, Sharpe MC, Dobbins JG, Komaroff A (1994). "The chronic fatigue syndrome: a comprehensive approach to its definition and study. International Chronic Fatigue Syndrome Study Group". Ann Intern Med. 121 (12): 953–9. doi:10.7326/0003-4819-121-12-199412150-00009. PMID 7978722.
- ↑ 3.0 3.1 ter Wolbeek M, van Doornen LJ, Kavelaars A, Heijnen CJ (2006). "Severe fatigue in adolescents: a common phenomenon?". Pediatrics. 117 (6): e1078–86. doi:10.1542/peds.2005-2575. PMID 16740810.
- ↑ Lloyd AR, Wakefield D, Hickie I (1993). "Immunity and the pathophysiology of chronic fatigue syndrome". Ciba Found Symp. 173: 176–87, discussion 187-92. doi:10.1002/9780470514382.ch11. PMID 8491097.
- ↑ 5.0 5.1 5.2 5.3 Nutini M, Karczewski M, Capoor J (2009). "Fatigue in children with neurologic impairments". Phys Med Rehabil Clin N Am. 20 (2): 339–46. doi:10.1016/j.pmr.2008.12.004. PMID 19389615.
- ↑ Wolfe J, Grier HE, Klar N, Levin SB, Ellenbogen JM, Salem-Schatz S; et al. (2000). "Symptoms and suffering at the end of life in children with cancer". N Engl J Med. 342 (5): 326–33. doi:10.1056/NEJM200002033420506. PMID 10655532.
- ↑ Amato MP, Goretti B, Ghezzi A, Lori S, Zipoli V, Portaccio E; et al. (2008). "Cognitive and psychosocial features of childhood and juvenile MS". Neurology. 70 (20): 1891–7. doi:10.1212/01.wnl.0000312276.23177.fa. PMID 18474844.
- ↑ 8.0 8.1 Van de Vijver E, Van Gils A, Beckers L, Van Driessche Y, Moes ND, van Rheenen PF (2019). "Fatigue in children and adolescents with inflammatory bowel disease". World J Gastroenterol. 25 (5): 632–643. doi:10.3748/wjg.v25.i5.632. PMC 6371006. PMID 30774277.
- ↑ Shen J, Barbera J, Shapiro CM (2006). "Distinguishing sleepiness and fatigue: focus on definition and measurement". Sleep Med Rev. 10 (1): 63–76. doi:10.1016/j.smrv.2005.05.004. PMID 16376590.
- ↑ 10.0 10.1 Haines LC, Saidi G, Cooke RW (2005). "Prevalence of severe fatigue in primary care". Arch Dis Child. 90 (4): 367–8. doi:10.1136/adc.2003.039917. PMC 1720362. PMID 15781924.
- ↑ Carter BD, Marshall GS (1995). "New developments: diagnosis and management of chronic fatigue in children and adolescents". Curr Probl Pediatr. 25 (9): 281–93. doi:10.1016/s0045-9380(06)80057-5. PMID 8582157.
- ↑ Bell KM, Cookfair D, Bell DS, Reese P, Cooper L (1991). "Risk factors associated with chronic fatigue syndrome in a cluster of pediatric cases". Rev Infect Dis. 13 Suppl 1: S32–8. doi:10.1093/clinids/13.supplement_1.s32. PMID 2020801.
- ↑ 13.0 13.1 Rimes KA, Goodman R, Hotopf M, Wessely S, Meltzer H, Chalder T (2007). "Incidence, prognosis, and risk factors for fatigue and chronic fatigue syndrome in adolescents: a prospective community study". Pediatrics. 119 (3): e603–9. doi:10.1542/peds.2006-2231. PMID 17332180.
- ↑ Mears CJ, Taylor RR, Jordan KM, Binns HJ, Pediatric Practice Research Group (2004). "Sociodemographic and symptom correlates of fatigue in an adolescent primary care sample". J Adolesc Health. 35 (6): 528e.21–6. doi:10.1016/j.jadohealth.2004.02.012. PMID 15581533.
- ↑ Carter BD, Edwards JF, Kronenberger WG, Michalczyk L, Marshall GS (1995). "Case control study of chronic fatigue in pediatric patients". Pediatrics. 95 (2): 179–86. PMID 7838632.
- ↑ Crichton A, Knight S, Oakley E, Babl FE, Anderson V (2015). "Fatigue in child chronic health conditions: a systematic review of assessment instruments". Pediatrics. 135 (4): e1015–31. doi:10.1542/peds.2014-2440. PMID 25802352.
- ↑ Varni JW, Burwinkle TM, Szer IS (2004). "The PedsQL Multidimensional Fatigue Scale in pediatric rheumatology: reliability and validity". J Rheumatol. 31 (12): 2494–500. PMID 15570657.
- ↑ Varni JW, Limbers CA, Bryant WP, Wilson DP (2009). "The PedsQL Multidimensional Fatigue Scale in type 1 diabetes: feasibility, reliability, and validity". Pediatr Diabetes. 10 (5): 321–8. doi:10.1111/j.1399-5448.2008.00482.x. PMID 19067887.
- ↑ Hockenberry MJ, Hinds PS, Barrera P, Bryant R, Adams-McNeill J, Hooke C; et al. (2003). "Three instruments to assess fatigue in children with cancer: the child, parent and staff perspectives". J Pain Symptom Manage. 25 (4): 319–28. doi:10.1016/s0885-3924(02)00680-2. PMID 12691683.
- ↑ Chiang YC, Hinds PS, Yeh CH, Yang CP (2008). "Development and psychometric testing of a Chinese version of the Fatigue Scale-Children in Taiwan". J Clin Nurs. 17 (9): 1201–10. doi:10.1111/j.1365-2702.2007.02138.x. PMID 18416796.
- ↑ 21.0 21.1 Crawley E (2017). "Pediatric chronic fatigue syndrome: current perspectives". Pediatric Health Med Ther. 9: 27–33. doi:10.2147/PHMT.S126253. PMC 5919160. PMID 29722371.
- ↑ Gordon BA, Knapman LM, Lubitz L (2010). "Graduated exercise training and progressive resistance training in adolescents with chronic fatigue syndrome: a randomized controlled pilot study". Clin Rehabil. 24 (12): 1072–9. doi:10.1177/0269215510371429. PMID 20605858.
- ↑ Segal TY, Hindmarsh PC, Viner RM (2005). "Disturbed adrenal function in adolescents with chronic fatigue syndrome". J Pediatr Endocrinol Metab. 18 (3): 295–301. doi:10.1515/jpem.2005.18.3.295. PMID 15813608.
- ↑ 24.0 24.1 Rowe PC, Underhill RA, Friedman KJ, Gurwitt A, Medow MS, Schwartz MS; et al. (2017). "Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Diagnosis and Management in Young People: A Primer". Front Pediatr. 5: 121. doi:10.3389/fped.2017.00121. PMC 5474682. PMID 28674681.
- ↑ Tucker P, Haig-Ferguson A, Eaton N, Crawley E (2011). "What to do about attention and memory problems in children with CFS/ME: a neuropsychological approach". Clin Child Psychol Psychiatry. 16 (2): 215–23. doi:10.1177/1359104511403585. PMID 21571764.