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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Follitropin subunit beta''' also known as '''follicle-stimulating hormone beta subunit''' (FSH-B) is a [[protein]] that in humans is encoded by the ''FSHB'' [[gene]].<ref name="pmid2885163">{{cite journal |vauthors=Watkins PC, Eddy R, Beck AK, Vellucci V, Leverone B, Tanzi RE, Gusella JF, Shows TB | title = DNA sequence and regional assignment of the human follicle-stimulating hormone beta-subunit gene to the short arm of human chromosome 11 | journal = DNA | volume = 6 | issue = 3 | pages = 205–12 |date=Aug 1987 | pmid = 2885163 | pmc =  | doi =10.1089/dna.1987.6.205  }}</ref><ref name="pmid3151250">{{cite journal |vauthors=Shome B, Parlow AF, Liu WK, Nahm HS, Wen T, Ward DN | title = A reevaluation of the amino acid sequence of human follitropin beta-subunit | journal = J Protein Chem | volume = 7 | issue = 4 | pages = 325–39 |date=Sep 1989 | pmid = 3151250 | pmc = | doi =10.1007/BF01024882  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: FSHB follicle stimulating hormone, beta polypeptide| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2488| accessdate = }}</ref>  Alternative splicing results in two transcript variants encoding the same protein.
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_FSHB_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1fl7.
| PDB = {{PDB2|1fl7}}, {{PDB2|1xwd}}
| Name = Follicle stimulating hormone, beta polypeptide
| HGNCid = 3964
| Symbol = FSHB
| AltSymbols =;
| OMIM = 136530
| ECnumber = 
| Homologene = 430
| MGIid = 95582
| GeneAtlas_image1 = PBB_GE_FSHB_214489_at_tn.png
| Function = {{GNF_GO|id=GO:0016913 |text = follicle-stimulating hormone activity}} {{GNF_GO|id=GO:0046982 |text = protein heterodimerization activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005625 |text = soluble fraction}}
| Process = {{GNF_GO|id=GO:0001541 |text = ovarian follicle development}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007283 |text = spermatogenesis}} {{GNF_GO|id=GO:0007292 |text = female gamete generation}} {{GNF_GO|id=GO:0007565 |text = female pregnancy}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2488
    | Hs_Ensembl = ENSG00000131808
    | Hs_RefseqProtein = NP_000501
    | Hs_RefseqmRNA = NM_000510
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 30209139
    | Hs_GenLoc_end = 30213384
    | Hs_Uniprot = P01225
    | Mm_EntrezGene = 14308
    | Mm_Ensembl = ENSMUSG00000027120
    | Mm_RefseqmRNA = NM_008045
    | Mm_RefseqProtein = NP_032071
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 106856973
    | Mm_GenLoc_end = 106860490
    | Mm_Uniprot = Q60687
  }}
}}
'''Follicle stimulating hormone, beta polypeptide''', also known as '''FSHB''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: FSHB follicle stimulating hormone, beta polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2488| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The [[pituitary]] [[glycoprotein]] hormone family includes [[follicle-stimulating hormone]], [[luteinizing hormone]], [[chorionic gonadotropin]], and [[thyroid-stimulating hormone]]. All of these glycoproteins consist of an identical [[chorionic gonadotropin alpha|alpha subunit]] and a hormone-specific beta subunit. This gene encodes the beta subunit of follicle-stimulating hormone. In conjunction with luteinizing hormone, follicle-stimulating hormone induces egg and sperm production.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = The pituitary glycoprotein hormone family includes follicle-stimulating hormone, luteinizing hormone, chorionic gonadotropin, and thyroid-stimulating hormone. All of these glycoproteins consist of an identical alpha subunit and a hormone-specific beta subunit. This gene encodes the beta subunit of follicle-stimulating hormone. In conjunction with luteinizing hormone, follicle-stimulating hormone induces egg and sperm production. Alternative splicing results in two transcript variants encoding the same protein.<ref name="entrez">{{cite web | title = Entrez Gene: FSHB follicle stimulating hormone, beta polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2488| accessdate = }}</ref>
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal  | author=Barrios-De-Tomasi J |title=Assessment of the in vitro and in vivo biological activities of the human follicle-stimulating isohormones |journal=Mol. Cell. Endocrinol. |volume=186 |issue= 2 |pages= 189–98 |year= 2002 |pmid= 11900895 |doi=10.1016/S0303-7207(01)00657-8 |name-list-format=vanc| author2=Timossi C | author3=Merchant H  | display-authors=3  | last4=Quintanar  | first4=A  | last5=Avalos  | first5=J.M  | last6=Andersen  | first6=C.Yding  | last7=Ulloa-Aguirre  | first7=A }}
| citations =
*{{cite journal  |vauthors=Saxena BB, Rathnam P |title=Amino acid sequence of the beta subunit of follicle-stimulating hormone from human pituitary glands |journal=J. Biol. Chem. |volume=251 |issue= 4 |pages= 993–1005 |year= 1976 |pmid= 1249074 |doi=  }}
*{{cite journal  | author=Barrios-De-Tomasi J, Timossi C, Merchant H, ''et al.'' |title=Assessment of the in vitro and in vivo biological activities of the human follicle-stimulating isohormones. |journal=Mol. Cell. Endocrinol. |volume=186 |issue= 2 |pages= 189-98 |year= 2002 |pmid= 11900895 |doi=  }}
*{{cite journal  | author=Keene JL |title=Expression of biologically active human follitropin in Chinese hamster ovary cells |journal=J. Biol. Chem. |volume=264 |issue= 9 |pages= 4769–75 |year= 1989 |pmid= 2494176 |doi=  |name-list-format=vanc| author2=Matzuk MM  | author3=Otani T  | display-authors=3  | last4=Fauser  | first4=BC  | last5=Galway  | first5=AB  | last6=Hsueh  | first6=AJ  | last7=Boime  | first7=I }}
*{{cite journal | author=Saxena BB, Rathnam P |title=Amino acid sequence of the beta subunit of follicle-stimulating hormone from human pituitary glands. |journal=J. Biol. Chem. |volume=251 |issue= 4 |pages= 993-1005 |year= 1976 |pmid= 1249074 |doi=  }}
*{{cite journal  |vauthors=Jameson JL, Becker CB, Lindell CM, Habener JF |title=Human follicle-stimulating hormone beta-subunit gene encodes multiple messenger ribonucleic acids |journal=Mol. Endocrinol. |volume=2 |issue= 9 |pages= 806–15 |year= 1988 |pmid= 3139991 |doi=10.1210/mend-2-9-806 }}
*{{cite journal  | author=Keene JL, Matzuk MM, Otani T, ''et al.'' |title=Expression of biologically active human follitropin in Chinese hamster ovary cells. |journal=J. Biol. Chem. |volume=264 |issue= 9 |pages= 4769-75 |year= 1989 |pmid= 2494176 |doi=  }}
*{{cite journal  |vauthors=Shome B, Parlow AF |title=Human follicle stimulating hormone: first proposal for the amino acid sequence of the hormone-specific, beta subunit (hFSHb) |journal=J. Clin. Endocrinol. Metab. |volume=39 |issue= 1 |pages= 203–5 |year= 1974 |pmid= 4835136 |doi=10.1210/jcem-39-1-203 }}
*{{cite journal  | author=Watkins PC, Eddy R, Beck AK, ''et al.'' |title=DNA sequence and regional assignment of the human follicle-stimulating hormone beta-subunit gene to the short arm of human chromosome 11. |journal=DNA |volume=6 |issue= 3 |pages= 205-12 |year= 1987 |pmid= 2885163 |doi=  }}
*{{cite journal  |vauthors=Fujiki Y, Rathnam P, Saxena BB |title=Studies on the disulfide bonds in human pituitary follicle-stimulating hormone |journal=Biochim. Biophys. Acta |volume=624 |issue= 2 |pages= 428–35 |year= 1980 |pmid= 6774759 |doi=  10.1016/0005-2795(80)90084-7}}
*{{cite journal  | author=Jameson JL, Becker CB, Lindell CM, Habener JF |title=Human follicle-stimulating hormone beta-subunit gene encodes multiple messenger ribonucleic acids. |journal=Mol. Endocrinol. |volume=2 |issue= 9 |pages= 806-15 |year= 1988 |pmid= 3139991 |doi=  }}
*{{cite journal  |vauthors=Böckers TM, Nieschlag E, Kreutz MR, Bergmann M |title=Localization of follicle-stimulating hormone (FSH) immunoreactivity and hormone receptor mRNA in testicular tissue of infertile men |journal=Cell Tissue Res. |volume=278 |issue= 3 |pages= 595–600 |year= 1995 |pmid= 7850869 |doi=10.1007/BF00331379 }}
*{{cite journal  | author=Shome B, Parlow AF, Liu WK, ''et al.'' |title=A reevaluation of the amino acid sequence of human follitropin beta-subunit. |journal=J. Protein Chem. |volume=7 |issue= 4 |pages= 325-39 |year= 1989 |pmid= 3151250 |doi=  }}
*{{cite journal  | author=Matthews CH |title=Primary amenorrhoea and infertility due to a mutation in the beta-subunit of follicle-stimulating hormone |journal=Nat. Genet. |volume=5 |issue= 1 |pages= 83–6 |year= 1993 |pmid= 8220432 |doi= 10.1038/ng0993-83  |name-list-format=vanc| author2=Borgato S  | author3=Beck-Peccoz P  | display-authors=3  | last4=Adams  | first4=M.  | last5=Tone  | first5=Y.  | last6=Gambino  | first6=G.  | last7=Casagrande  | first7=S.  | last8=Tedeschini  | first8=G.  | last9=Benedetti | first9=A. }}
*{{cite journal  | author=Shome B, Parlow AF |title=Human follicle stimulating hormone: first proposal for the amino acid sequence of the hormone-specific, beta subunit (hFSHb). |journal=J. Clin. Endocrinol. Metab. |volume=39 |issue= 1 |pages= 203-5 |year= 1974 |pmid= 4835136 |doi=  }}
*{{cite journal  | author=Layman LC |title=Delayed puberty and hypogonadism caused by mutations in the follicle-stimulating hormone beta-subunit gene |journal=N. Engl. J. Med. |volume=337 |issue= 9 |pages= 607–11 |year= 1997 |pmid= 9271483 |doi=10.1056/NEJM199708283370905 |name-list-format=vanc| author2=Lee EJ  | author3=Peak DB  | display-authors=3  | last4=Namnoum  | first4=Anne B.  | last5=Vu  | first5=Kenneth V.  | last6=Van Lingen  | first6=Barbara L.  | last7=Gray  | first7=Mark R. | last8=McDonough  | first8=Paul G. | last9=Reindollar  | first9=Richard H. }}
*{{cite journal  | author=Fujiki Y, Rathnam P, Saxena BB |title=Studies on the disulfide bonds in human pituitary follicle-stimulating hormone. |journal=Biochim. Biophys. Acta |volume=624 |issue= 2 |pages= 428-35 |year= 1980 |pmid= 6774759 |doi=  }}
*{{cite journal  | author=Cargill M |title=Characterization of single-nucleotide polymorphisms in coding regions of human genes |journal=Nat. Genet. |volume=22 |issue= 3 |pages= 231–8 |year= 1999 |pmid= 10391209 |doi= 10.1038/10290 |name-list-format=vanc| author2=Altshuler D  | author3=Ireland J  | display-authors=3  | last4=Ireland  | first4=James  | last5=Sklar  | first5=Pamela  | last6=Ardlie  | first6=Kristin  | last7=Patil  | first7=Nila  | last8=Lane  | first8=Charles R.  | last9=Lim | first9=Esther P. }}
*{{cite journal  | author=Böckers TM, Nieschlag E, Kreutz MR, Bergmann M |title=Localization of follicle-stimulating hormone (FSH) immunoreactivity and hormone receptor mRNA in testicular tissue of infertile men. |journal=Cell Tissue Res. |volume=278 |issue= 3 |pages= 595-600 |year= 1995 |pmid= 7850869 |doi=  }}
*{{cite journal  |vauthors=Grasso P, Rozhavskaya-Arena M, Reichert LE |title=Cysteine residues in a synthetic peptide corresponding to human follicle-stimulating hormone beta-subunit receptor-binding domain 81-95 [hFSH-beta-(81-95)] modulate the in vivo effects of hFSH-beta-(81-95) on the mouse estrous cycle |journal=Regul. Pept. |volume=81 |issue= 1–3 |pages= 67–71 |year= 1999 |pmid= 10395410 |doi=10.1016/S0167-0115(99)00022-1 }}
*{{cite journal  | author=Matthews CH, Borgato S, Beck-Peccoz P, ''et al.'' |title=Primary amenorrhoea and infertility due to a mutation in the beta-subunit of follicle-stimulating hormone. |journal=Nat. Genet. |volume=5 |issue= 1 |pages= 83-6 |year= 1993 |pmid= 8220432 |doi= 10.1038/ng0993-83 }}
*{{cite journal  | author=Ben-Menahem D |title=Synthesis of multi-subunit domain gonadotropin complexes: a model for alpha/beta heterodimer formation |journal=Biochemistry |volume=38 |issue= 46 |pages= 15070–7 |year= 1999 |pmid= 10563789 |doi=10.1021/bi991510c |name-list-format=vanc| author2=Hyde R | author3=Pixley M  | display-authors=3  | last4=Berger  | first4=Peter  | last5=Boime  | first5=Irving  }}
*{{cite journal | author=Layman LC, Lee EJ, Peak DB, ''et al.'' |title=Delayed puberty and hypogonadism caused by mutations in the follicle-stimulating hormone beta-subunit gene. |journal=N. Engl. J. Med. |volume=337 |issue= 9 |pages= 607-11 |year= 1997 |pmid= 9271483 |doi=  }}
*{{cite journal  | author=Dias Neto E |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491–6 |year= 2000 |pmid= 10737800 |doi=10.1073/pnas.97.7.3491  | pmc=16267  |name-list-format=vanc| author2=Correa RG  | author3=Verjovski-Almeida S  | display-authors=3  | last4=Briones  | first4=MR  | last5=Nagai  | first5=MA  | last6=Da Silva Jr  | first6=W  | last7=Zago  | first7=MA  | last8=Bordin  | first8=S  | last9=Costa  | first9=FF  }}
*{{cite journal  | author=Cargill M, Altshuler D, Ireland J, ''et al.'' |title=Characterization of single-nucleotide polymorphisms in coding regions of human genes. |journal=Nat. Genet. |volume=22 |issue= 3 |pages= 231-8 |year= 1999 |pmid= 10391209 |doi= 10.1038/10290 }}
*{{cite journal  |vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA Cloning Using In Vitro Site-Specific Recombination |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000  | pmc=310948  }}
*{{cite journal | author=Grasso P, Rozhavskaya-Arena M, Reichert LE |title=Cysteine residues in a synthetic peptide corresponding to human follicle-stimulating hormone beta-subunit receptor-binding domain 81-95 [hFSH-beta-(81-95)] modulate the in vivo effects of hFSH-beta-(81-95) on the mouse estrous cycle. |journal=Regul. Pept. |volume=81 |issue= 1-3 |pages= 67-71 |year= 1999 |pmid= 10395410 |doi=  }}
*{{cite journal  |vauthors=Fox KM, Dias JA, Van Roey P |title=Three-dimensional structure of human follicle-stimulating hormone |journal=Mol. Endocrinol. |volume=15 |issue= 3 |pages= 378–89 |year= 2001 |pmid= 11222739 |doi=10.1210/me.15.3.378  }}
*{{cite journal  | author=Ben-Menahem D, Hyde R, Pixley M, ''et al.'' |title=Synthesis of multi-subunit domain gonadotropin complexes: a model for alpha/beta heterodimer formation. |journal=Biochemistry |volume=38 |issue= 46 |pages= 15070-7 |year= 1999 |pmid= 10563789 |doi= }}
*{{cite journal  | author=Amoresano A |title=Assignment of the complete disulphide bridge pattern in the human recombinant follitropin beta-chain |journal=Biol. Chem. |volume=382 |issue= 6 |pages= 961–8 |year= 2002 |pmid= 11501762 |doi=10.1515/BC.2001.120  |name-list-format=vanc| author2=Orrù S  | author3=Siciliano RA  | display-authors=3  | last4=Luca  | first4=Eva De  | last5=Napoleoni  | first5=Roberta  | last6=Sirna  | first6=Antonino  | last7=Pucci  | first7=Piero  }}
*{{cite journal | author=Dias Neto E, Correa RG, Verjovski-Almeida S, ''et al.'' |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491-6 |year= 2000 |pmid= 10737800 |doi=  }}
*{{cite journal  | author=Walton WJ |title=Characterization of human FSH isoforms reveals a nonglycosylated beta-subunit in addition to the conventional glycosylated beta-subunit |journal=J. Clin. Endocrinol. Metab. |volume=86 |issue= 8 |pages= 3675–85 |year= 2001 |pmid= 11502795 |doi=10.1210/jc.86.8.3675  |name-list-format=vanc| author2=Nguyen VT  | author3=Butnev VY  | display-authors=3  | last4=Singh  | first4=V  | last5=Moore  | first5=WT  | last6=Bousfield  | first6=GR }}
*{{cite journal  | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi=  }}
*{{cite journal | author=Fox KM, Dias JA, Van Roey P |title=Three-dimensional structure of human follicle-stimulating hormone. |journal=Mol. Endocrinol. |volume=15 |issue= 3 |pages= 378-89 |year= 2001 |pmid= 11222739 |doi=  }}
*{{cite journal  | author=Amoresano A, Orrù S, Siciliano RA, ''et al.'' |title=Assignment of the complete disulphide bridge pattern in the human recombinant follitropin beta-chain. |journal=Biol. Chem. |volume=382 |issue= 6 |pages= 961-8 |year= 2002 |pmid= 11501762 |doi=  }}
*{{cite journal | author=Walton WJ, Nguyen VT, Butnev VY, ''et al.'' |title=Characterization of human FSH isoforms reveals a nonglycosylated beta-subunit in addition to the conventional glycosylated beta-subunit. |journal=J. Clin. Endocrinol. Metab. |volume=86 |issue= 8 |pages= 3675-85 |year= 2001 |pmid= 11502795 |doi=  }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{PDB Gallery|geneid=2488}}
{{WikiDoc Sources}}
{{Hormones}}
{{Protein and peptide receptor modulators}}
 
 
{{gene-11-stub}}

Latest revision as of 01:49, 27 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

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Ensembl

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UniProt

n/a

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RefSeq (mRNA)

n/a

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RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Follitropin subunit beta also known as follicle-stimulating hormone beta subunit (FSH-B) is a protein that in humans is encoded by the FSHB gene.[1][2][3] Alternative splicing results in two transcript variants encoding the same protein.

Function

The pituitary glycoprotein hormone family includes follicle-stimulating hormone, luteinizing hormone, chorionic gonadotropin, and thyroid-stimulating hormone. All of these glycoproteins consist of an identical alpha subunit and a hormone-specific beta subunit. This gene encodes the beta subunit of follicle-stimulating hormone. In conjunction with luteinizing hormone, follicle-stimulating hormone induces egg and sperm production.[3]

References

  1. ↑ Watkins PC, Eddy R, Beck AK, Vellucci V, Leverone B, Tanzi RE, Gusella JF, Shows TB (Aug 1987). "DNA sequence and regional assignment of the human follicle-stimulating hormone beta-subunit gene to the short arm of human chromosome 11". DNA. 6 (3): 205–12. doi:10.1089/dna.1987.6.205. PMID 2885163.
  2. ↑ Shome B, Parlow AF, Liu WK, Nahm HS, Wen T, Ward DN (Sep 1989). "A reevaluation of the amino acid sequence of human follitropin beta-subunit". J Protein Chem. 7 (4): 325–39. doi:10.1007/BF01024882. PMID 3151250.
  3. ↑ 3.0 3.1 "Entrez Gene: FSHB follicle stimulating hormone, beta polypeptide".

Further reading

  • Barrios-De-Tomasi J, Timossi C, Merchant H, et al. (2002). "Assessment of the in vitro and in vivo biological activities of the human follicle-stimulating isohormones". Mol. Cell. Endocrinol. 186 (2): 189–98. doi:10.1016/S0303-7207(01)00657-8. PMID 11900895.
  • Saxena BB, Rathnam P (1976). "Amino acid sequence of the beta subunit of follicle-stimulating hormone from human pituitary glands". J. Biol. Chem. 251 (4): 993–1005. PMID 1249074.
  • Keene JL, Matzuk MM, Otani T, et al. (1989). "Expression of biologically active human follitropin in Chinese hamster ovary cells". J. Biol. Chem. 264 (9): 4769–75. PMID 2494176.
  • Jameson JL, Becker CB, Lindell CM, Habener JF (1988). "Human follicle-stimulating hormone beta-subunit gene encodes multiple messenger ribonucleic acids". Mol. Endocrinol. 2 (9): 806–15. doi:10.1210/mend-2-9-806. PMID 3139991.
  • Shome B, Parlow AF (1974). "Human follicle stimulating hormone: first proposal for the amino acid sequence of the hormone-specific, beta subunit (hFSHb)". J. Clin. Endocrinol. Metab. 39 (1): 203–5. doi:10.1210/jcem-39-1-203. PMID 4835136.
  • Fujiki Y, Rathnam P, Saxena BB (1980). "Studies on the disulfide bonds in human pituitary follicle-stimulating hormone". Biochim. Biophys. Acta. 624 (2): 428–35. doi:10.1016/0005-2795(80)90084-7. PMID 6774759.
  • Böckers TM, Nieschlag E, Kreutz MR, Bergmann M (1995). "Localization of follicle-stimulating hormone (FSH) immunoreactivity and hormone receptor mRNA in testicular tissue of infertile men". Cell Tissue Res. 278 (3): 595–600. doi:10.1007/BF00331379. PMID 7850869.
  • Matthews CH, Borgato S, Beck-Peccoz P, et al. (1993). "Primary amenorrhoea and infertility due to a mutation in the beta-subunit of follicle-stimulating hormone". Nat. Genet. 5 (1): 83–6. doi:10.1038/ng0993-83. PMID 8220432.
  • Layman LC, Lee EJ, Peak DB, et al. (1997). "Delayed puberty and hypogonadism caused by mutations in the follicle-stimulating hormone beta-subunit gene". N. Engl. J. Med. 337 (9): 607–11. doi:10.1056/NEJM199708283370905. PMID 9271483.
  • Cargill M, Altshuler D, Ireland J, et al. (1999). "Characterization of single-nucleotide polymorphisms in coding regions of human genes". Nat. Genet. 22 (3): 231–8. doi:10.1038/10290. PMID 10391209.
  • Grasso P, Rozhavskaya-Arena M, Reichert LE (1999). "Cysteine residues in a synthetic peptide corresponding to human follicle-stimulating hormone beta-subunit receptor-binding domain 81-95 [hFSH-beta-(81-95)] modulate the in vivo effects of hFSH-beta-(81-95) on the mouse estrous cycle". Regul. Pept. 81 (1–3): 67–71. doi:10.1016/S0167-0115(99)00022-1. PMID 10395410.
  • Ben-Menahem D, Hyde R, Pixley M, et al. (1999). "Synthesis of multi-subunit domain gonadotropin complexes: a model for alpha/beta heterodimer formation". Biochemistry. 38 (46): 15070–7. doi:10.1021/bi991510c. PMID 10563789.
  • Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Fox KM, Dias JA, Van Roey P (2001). "Three-dimensional structure of human follicle-stimulating hormone". Mol. Endocrinol. 15 (3): 378–89. doi:10.1210/me.15.3.378. PMID 11222739.
  • Amoresano A, Orrù S, Siciliano RA, et al. (2002). "Assignment of the complete disulphide bridge pattern in the human recombinant follitropin beta-chain". Biol. Chem. 382 (6): 961–8. doi:10.1515/BC.2001.120. PMID 11501762.
  • Walton WJ, Nguyen VT, Butnev VY, et al. (2001). "Characterization of human FSH isoforms reveals a nonglycosylated beta-subunit in addition to the conventional glycosylated beta-subunit". J. Clin. Endocrinol. Metab. 86 (8): 3675–85. doi:10.1210/jc.86.8.3675. PMID 11502795.


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