Eosinophilia

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Eosinophilia
DiseasesDB 4328

Eosinophilia Microchapters

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Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Eosinophilia from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms

Physical Examination

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Future or Investigational Therapies

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Case #1

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Risk calculators and risk factors for Eosinophilia

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Lakshmi Gopalakrishnan, M.B.B.S. [2]

Overview

  • Eosinphilia refers to a group of idiopathic, neoplastic, infectious and allergic illnesses
  • Eosinphilia is associated with abnormally high number of eosinphil granulocytes in the serum and/or tissue
  • Reference range: 0-450 ul

Differential Diagnosis of Causes of Eosinophilia

By Organ System

Cardiovascular Endomyocardial fibrosis, Cholesterol embolism, Loeffler endocarditis , Eosinophilic myocarditis
Chemical / poisoning No underlying causes
Dermatologic Erythema multiforme, Atopic dermatitis, Dermatitis herpetiformis, Eosinophilic fasciitis, Eosinophilic pustular folliculitis, Pemphigus vulgaris, Psoriasis, Systemic lupus erythematosus, Sarcoptes scabiei, Eczema , Exfoliative dermatitis , Urticaria , Eosinophilic panniculitis , Shulman’s syndrome , Stevens - Johnson syndrome , Duhring disease , Histiositosis with cutaneous involvement
Drug Side Effect Sulphonamides, Allopurinol, Amitriptyline, Capreomycin, Caspofungin, Chlorpropamide, Clomipramine, Daptomycin, Desipramine, Dothiepin, Doxycycline, Enfuvirtide, Etravirine, Gold salts, Granulocyte-macrophage colony stimulating factor, Hydralazine, Imipramine, Interleukin 2, Micafungin, Minocycline, Nalidixic acid, Nitrofurantoin, Nortriptyline, Olanzapine, Oxytetracycline, Pentostatin, Procarbazine, Tobacco smoking, Tryptophan, Vancomycin, Aldesleukin , Amikacin Sulfate , Capastat Sulfate , Capreomycin Sulfate , Cefotaxime Sodium , Cefoxitin Sodium , Ceftazidime , Cefuroxime , LyphocinMaolate
Ear Nose Throat No underlying causes
Endocrine Adrenal cortex insufficiency, Addisons disease , Adrenocortical insufficiency
Environmental An allergic reaction to an environmental antigen
Gastroenterologic Inflammatory Bowel Disease , Cirrhosis of liver , Chronic active hepatitis , Eosinophilic Gastroenteritis , Peritoneal dialysis
Genetic Autoimmune lymphoproliferative syndrome type 1, Autoimmune lymphoproliferative syndrome type 2, Familial eosinophilia, Kostmann disease, Omenn syndrome, Wiskott-Aldrich syndrome, TAR syndrome, kostmann syndrome, Chromosome 21 partial deletion
Hematologic Acute lymphoblastic leukemia, Chronic myeloid leukaemia, Hodgkin lymphoma, Thrombocytopenia with absent radii , Familial reticuloendotheliosis with eosinophilia
Iatrogenic Radiotherapy
Infectious Disease Acanthocheilonemiasis, Alveolar hydatid disease, Ancylostoma caninum, Ancylostoma duodenale, Angiostrongyliasis, Anisakiasis, Ascariasis, Capillaria, Clonorchiasis, Coccidioidomycosis, Dicrocoelium dendriticum fluke, Dracunculiasis, Echinococcus granulosus, Fasciola hepatica, Gnathostomiasis, Heterophyiasis, Lepromatous leprosy, Loa loa filariasis, Lymphatic filariasis, Mansonelliasis, Metagonimiasis, Mycobacterium tuberculosis, Onchocerciasis, Opisthorchiasis, Paragonimiasis, Schistosoma haematobium, Schistosoma mansoni, Strongyloidiasis, Toxocariasis, Trichinella spiralis, Pneumocystis jirovecii infection , Visceral larva migrans , Brucellosis , Cat-scratch fever , Chlamydial pneumonia of infancy , Infectious lymphocytosis , Infectious mononucleosis , Scarlet fever, Amebiasis , Malaria
Musculoskeletal / Ortho Polyarteritis nodosa, Polymyositis, Rheumatoid disease, Dressler's syndrome , Eosinophilic fasciitis , Idiopathic eosinophilic synovitis , Progressive systemic sclerosis (scleroderma) , SLE , Sjögren's syndrome , Sarcoidosis , Eosinophilia – Myalgia syndrome , Dermatomyositis
Neurologic No underlying causes
Nutritional / Metabolic No underlying causes
Obstetric/Gynecologic No underlying causes
Oncologic Acute lymphoblastic leukemia, Chronic myeloid leukaemia, Hodgkin lymphoma, Immunoblastic lymphadenopathy , Sarcomas and carcinomas of ovary, Carcinoma of pancreas , Carcinoma of lung , Carcinoma of colon, Carcinoma of cervix , Acute eosinophilic leukemia , Chronic eosinophilic leukemia , Brain tumors
Opthalmologic No underlying causes
Overdose / Toxicity No underlying causes
Psychiatric No underlying causes
Pulmonary Simple pulmonary eosinophilia, Visceral larva migrans, Allergic bronchopulmonary aspergillosis, Extrinsic allergic alveolitis, Tropical pulmonary eosinophilia, Churg-Strauss syndrome, Bronchial asthma, Allergic Rhinitis, Chronic eosinophilic pneumonia , Occupational lung diseases , Idiopathic eosinophilic chronic pneumopathy , Magrassi- Leonardi syndrome
Renal / Electrolyte Interstitial nephritis, Eosinophilic cystitis , Hemodialysis , CRF not on renal replacement therapy , Diffuse proliferative glomerular nephritis , Thrombotic thrombocytopenic purpura , Renal cell carcinoma
Rheum / Immune / Allergy Eosinophilia-myalgia syndrome,Hyper-IgE syndrome , IgA deficiency , Wiskott-Aldrich syndrome ,Graft versus host immunologic reactions ,Milk protein allergy , Omenn syndrome , Severe congenital Neutropenia
Sexual No underlying causes
Trauma No underlying causes
Urologic No underlying causes
Miscellaneous Angiolymphoid hyperplasia with eosinophilia, Eosinophilic cellulitis, Hypereosinophilic syndrome, Kimura disease, Familial eosinophilia , Episodic angioedema with eosinophilia , Aggressive systemic mastocytosis

In alphabetical order [1]

Related Chapters

References

  1. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:127-128 ISBN 1591032016


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