Mycobacterium tuberculosis

Jump to navigation Jump to search

Tuberculosis Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Tuberculosis from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Children

HIV Coinfection

Diagnosis

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

Chest X Ray

CT

MRI

Echocardiography or Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Special Conditions
Drug-resistant

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Mycobacterium tuberculosis On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Mycobacterium tuberculosis

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Mycobacterium tuberculosis

CDC on Mycobacterium tuberculosis

Mycobacterium tuberculosis in the news

Blogs on Mycobacterium tuberculosis

Directions to Hospitals Treating Tuberculosis

Risk calculators and risk factors for Mycobacterium tuberculosis

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mashal Awais, M.D.[2]; João André Alves Silva, M.D. [3]

This page is about microbiologic aspects of the organism(s).  For clinical aspects of the disease, see Tuberculosis.

Synonyms and Keywords: M. Tuberculosis

Overview

Mycobacterium tuberculosis is the bacterium responsible for tuberculosis. M. tuberculosis is an obligate aerobe, non-encapsulated, non-motile, acid-fast bacillus. . M. tuberculosis is one of the Mycobacterium tuberculosis complex, which also includes bacteria, such as M. bovis and M. africanum. The bacterium has a very slow rate of replication, and its genetic variations account for the different strains and the growing drug resistance. M. tuberculosis has tropism for different kinds of human cells, with preference for cells of the lung. The main natural reservoir for M. tuberculosis are Human beings; however, the bacteria can also infect other species.

Taxonomy

Computer-generated image of a cluster of rod-shaped drug-resistant Mycobacterium tuberculosis bacteria. Image provided by the CDC Centers for Disease Control and Prevention [1]
Thin agar culture plates reveal the results of a drug susceptibility test on Mycobacterium tuberculosis bacteria Image provided by the CDC Centers for Disease Control and Prevention [2]

Cellular organisms; bacteria; Actinobacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Corynebacterineae; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex; M. tuberculosis[3]

Biology

Tropism

There is no particular tissue tropism for M. tuberculosis and it can infect almost all human tissues. However, M. tuberculosis prefers tissues with high levels of oxygen , hence, pulmonary tuberculosis has the highest rate. [4]

Natural Reservoir

The main natural reservoir for M. tuberculosis are Human beings; however, the bacteria can also infect other species.[4]

References

  1. "http://phil.cdc.gov/phil/details.asp". External link in |title= (help)
  2. "http://phil.cdc.gov/phil/details.asp". External link in |title= (help)
  3. "Mycobacterium tuberculosis".
  4. 4.0 4.1 4.2 4.3 4.4 Lawn SD, Zumla AI (2011). "Tuberculosis". Lancet. 378 (9785): 57–72. doi:10.1016/S0140-6736(10)62173-3. PMID 21420161.
  5. Smith NH, Hewinson RG, Kremer K, Brosch R, Gordon SV (2009). "Myths and misconceptions: the origin and evolution of Mycobacterium tuberculosis". Nat Rev Microbiol. 7 (7): 537–44. doi:10.1038/nrmicro2165. PMID 19483712.
  6. Gagneux S, Small PM (2007). "Global phylogeography of Mycobacterium tuberculosis and implications for tuberculosis product development". Lancet Infect Dis. 7 (5): 328–37. doi:10.1016/S1473-3099(07)70108-1. PMID 17448936.