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{{Infobox_gene}}
'''Chloride channel accessory 2''' is a [[protein]] that in humans is encoded by the ''CLCA2'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CLCA2 chloride channel, calcium activated, family member 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9635| accessdate = }}</ref>
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{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene belongs to the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same site on chromosome 1p31-p22 and share high degrees of homology in size, sequence and predicted structure, but differ significantly in their tissue distributions. Since this protein is expressed predominantly in trachea and lung, it is suggested to play a role in the complex pathogenesis of cystic fibrosis. It may also serve as adhesion molecule for lung metastatic cancer cells, mediating vascular arrest and colonization, and furthermore, it has been implicated to act as a tumor suppressor gene for breast cancer.<ref name="entrez"/> Protein structure prediction methods suggest the N-terminal region of CLCA2 protein is a zinc [[metalloprotease]].<ref name="pmid16470849">{{cite journal | vauthors=Pawłowski K, Lepistö M, Meinander N |title=Novel conserved hydrolase domain in the CLCA family of alleged calcium-activated chloride channels |journal=Proteins |volume=63 |issue= 3 |pages= 424–39 |year= 2006 |pmid= 16470849|doi= 10.1002/prot.20887|display-authors=etal}}</ref>
}}
==See also==
* [[Chloride channel]]
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | vauthors=Pauli BU, Abdel-Ghany M, Cheng HC |title=Molecular characteristics and functional diversity of CLCA family members |journal=Clin. Exp. Pharmacol. Physiol. |volume=27 |issue= 11 |pages= 901–5 |year= 2001 |pmid= 11071307 |doi=10.1046/j.1440-1681.2000.03358.x |display-authors=etal}}
*{{cite journal | vauthors=Gruber AD, Schreur KD, Ji HL |title=Molecular cloning and transmembrane structure of hCLCA2 from human lung, trachea, and mammary gland |journal=Am. J. Physiol. |volume=276 |issue= 6 Pt 1 |pages= C1261–70 |year= 1999 |pmid= 10362588 |doi= |display-authors=etal}}
*{{cite journal | vauthors=Agnel M, Vermat T, Culouscou JM |title=Identification of three novel members of the calcium-dependent chloride channel (CaCC) family predominantly expressed in the digestive tract and trachea |journal=FEBS Lett. |volume=455 |issue= 3 |pages= 295–301 |year= 1999 |pmid= 10437792 |doi=10.1016/S0014-5793(99)00891-1 }}
*{{cite journal | vauthors=Gruber AD, Pauli BU |title=Tumorigenicity of human breast cancer is associated with loss of the Ca<sup>2+</sup>-activated chloride channel CLCA2 |journal=Cancer Res. |volume=59 |issue= 21 |pages= 5488–91 |year= 1999 |pmid= 10554024 |doi= }}
*{{cite journal | vauthors=Gruber AD, Pauli BU |title=Clustering of the human CLCA gene family on the short arm of chromosome 1 (1p22-31) |journal=Genome |volume=42 |issue= 5 |pages= 1030–2 |year= 1999 |pmid= 10584316 |doi=10.1139/gen-42-5-1030 }}
*{{cite journal | vauthors=Liu QH, Williams DA, McManus C |title=HIV-1 gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 9 |pages= 4832–7 |year= 2000 |pmid= 10758170 |doi= 10.1073/pnas.090521697 | pmc=18318 |display-authors=etal}}
*{{cite journal | vauthors=Koegel H, Alzheimer C |title=Expression and biological significance of Ca<sup>2+</sup>-activated ion channels in human keratinocytes |journal=FASEB J. |volume=15 |issue= 1 |pages= 145–154 |year= 2001 |pmid= 11149902 |doi= 10.1096/fj.00-0055com }}
*{{cite journal | vauthors=Itoh R, Kawamoto S, Miyamoto Y |title=Isolation and characterization of a Ca<sup>2+</sup>-activated chloride channel from human corneal epithelium |journal=Curr. Eye Res. |volume=21 |issue= 6 |pages= 918–25 |year= 2001 |pmid= 11262615 |doi=10.1076/ceyr.21.6.918.6983 |display-authors=etal}}
*{{cite journal | vauthors=Abdel-Ghany M, Cheng HC, Elble RC, Pauli BU |title=The breast cancer beta 4 integrin and endothelial human CLCA2 mediate lung metastasis |journal=J. Biol. Chem. |volume=276 |issue= 27 |pages= 25438–46 |year= 2001 |pmid= 11320086 |doi= 10.1074/jbc.M100478200 }}
*{{cite journal | vauthors=Abdel-Ghany M, Cheng HC, Elble RC, Pauli BU |title=Focal adhesion kinase activated by beta(4) integrin ligation to mCLCA1 mediates early metastatic growth |journal=J. Biol. Chem. |volume=277 |issue= 37 |pages= 34391–400 |year= 2002 |pmid= 12110680 |doi= 10.1074/jbc.M205307200 }}
*{{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal | vauthors=Mall M, Gonska T, Thomas J |title=Modulation of Ca<sup>2+</sup>-activated Cl<sup>−</sup> secretion by basolateral K<sup>+</sup> channels in human normal and cystic fibrosis airway epithelia |journal=Pediatr. Res. |volume=53 |issue= 4 |pages= 608–18 |year= 2003 |pmid= 12612194 |doi= 10.1203/01.PDR.0000057204.51420.DC |display-authors=etal}}
*{{cite journal | vauthors=Abdel-Ghany M, Cheng HC, Elble RC |title=The interacting binding domains of the beta(4) integrin and calcium-activated chloride channels (CLCAs) in metastasis |journal=J. Biol. Chem. |volume=278 |issue= 49 |pages= 49406–16 |year= 2004 |pmid= 14512419 |doi= 10.1074/jbc.M309086200 |display-authors=etal}}
*{{cite journal | vauthors=Connon CJ, Kawasaki S, Yamasaki K |title=The quantification of hCLCA2 and colocalisation with integrin beta4 in stratified human epithelia |journal=Acta Histochem. |volume=106 |issue= 6 |pages= 421–5 |year= 2005 |pmid= 15707651 |doi= 10.1016/j.acthis.2004.08.003 |display-authors=etal}}
*{{cite journal | vauthors=Connon CJ, Kawasaki S, Liles M |title=Gene expression and immunolocalisation of a calcium-activated chloride channel during the stratification of cultivated and developing corneal epithelium |journal=Cell Tissue Res. |volume=323 |issue= 1 |pages= 177–82 |year= 2006 |pmid= 16158324 |doi= 10.1007/s00441-005-0059-2 |display-authors=etal}}
*{{cite journal | vauthors=Elble RC, Walia V, Cheng HC |title=The putative chloride channel hCLCA2 has a single C-terminal transmembrane segment |journal=J. Biol. Chem. |volume=281 |issue= 40 |pages= 29448–54 |year= 2006 |pmid= 16873362 |doi= 10.1074/jbc.M605919200 |display-authors=etal}}
}}
{{refend}}
==External links==
* {{MeshName|CLCN1+protein,+human}}
* {{UCSC gene info|CLCA2}}
{{NLM content}}
{{Ion channels|g4}}
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
[[Category:Chloride channels]]
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Chloride channel, calcium activated, family member 2
| HGNCid = 2016
| Symbol = CLCA2
| AltSymbols =; CaCC
| OMIM = 604003
| ECnumber = 
| Homologene = 4765
| MGIid = 2139758
| GeneAtlas_image1 = PBB_GE_CLCA2_206165_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_CLCA2_206164_at_tn.png
| GeneAtlas_image3 = PBB_GE_CLCA2_206166_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005254 |text = chloride channel activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}}
| Process = {{GNF_GO|id=GO:0006810 |text = transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9635
    | Hs_Ensembl = ENSG00000137975
    | Hs_RefseqProtein = NP_006527
    | Hs_RefseqmRNA = NM_006536
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 86662357
    | Hs_GenLoc_end = 86694829
    | Hs_Uniprot = 
    | Mm_EntrezGene = 229933
    | Mm_Ensembl = ENSMUSG00000036960
    | Mm_RefseqmRNA = NM_178697
    | Mm_RefseqProtein = NP_848812
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 3
    | Mm_GenLoc_start = 145007653
    | Mm_GenLoc_end = 145036490
    | Mm_Uniprot = 
  }}
}}
'''Chloride channel, calcium activated, family member 2''', also known as '''CLCA2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CLCA2 chloride channel, calcium activated, family member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9635| accessdate = }}</ref>
 
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene belongs to the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same site on chromosome 1p31-p22 and share high degrees of homology in size, sequence and predicted structure, but differ significantly in their tissue distributions. Since this protein is expressed predominantly in trachea and lung, it is suggested to play a role in the complex pathogenesis of cystic fibrosis. It may also serve as adhesion molecule for lung metastatic cancer cells, mediating vascular arrest and colonization, and furthermore, it has been implicated to act as a tumor suppressor gene for breast cancer.<ref name="entrez">{{cite web | title = Entrez Gene: CLCA2 chloride channel, calcium activated, family member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9635| accessdate = }}</ref>
}}


==References==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  | author=Pauli BU, Abdel-Ghany M, Cheng HC, ''et al.'' |title=Molecular characteristics and functional diversity of CLCA family members. |journal=Clin. Exp. Pharmacol. Physiol. |volume=27 |issue= 11 |pages= 901-5 |year= 2001 |pmid= 11071307 |doi=  }}
*{{cite journal  | author=Gruber AD, Schreur KD, Ji HL, ''et al.'' |title=Molecular cloning and transmembrane structure of hCLCA2 from human lung, trachea, and mammary gland. |journal=Am. J. Physiol. |volume=276 |issue= 6 Pt 1 |pages= C1261-70 |year= 1999 |pmid= 10362588 |doi=  }}
*{{cite journal  | author=Agnel M, Vermat T, Culouscou JM |title=Identification of three novel members of the calcium-dependent chloride channel (CaCC) family predominantly expressed in the digestive tract and trachea. |journal=FEBS Lett. |volume=455 |issue= 3 |pages= 295-301 |year= 1999 |pmid= 10437792 |doi=  }}
*{{cite journal  | author=Gruber AD, Pauli BU |title=Tumorigenicity of human breast cancer is associated with loss of the Ca2+-activated chloride channel CLCA2. |journal=Cancer Res. |volume=59 |issue= 21 |pages= 5488-91 |year= 1999 |pmid= 10554024 |doi=  }}
*{{cite journal  | author=Gruber AD, Pauli BU |title=Clustering of the human CLCA gene family on the short arm of chromosome 1 (1p22-31). |journal=Genome |volume=42 |issue= 5 |pages= 1030-2 |year= 1999 |pmid= 10584316 |doi=  }}
*{{cite journal  | author=Liu QH, Williams DA, McManus C, ''et al.'' |title=HIV-1 gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 9 |pages= 4832-7 |year= 2000 |pmid= 10758170 |doi= 10.1073/pnas.090521697 }}
*{{cite journal  | author=Koegel H, Alzheimer C |title=Expression and biological significance of Ca2+-activated ion channels in human keratinocytes. |journal=FASEB J. |volume=15 |issue= 1 |pages= 145-154 |year= 2001 |pmid= 11149902 |doi= 10.1096/fj.00-0055com }}
*{{cite journal  | author=Itoh R, Kawamoto S, Miyamoto Y, ''et al.'' |title=Isolation and characterization of a Ca(2+)-activated chloride channel from human corneal epithelium. |journal=Curr. Eye Res. |volume=21 |issue= 6 |pages= 918-25 |year= 2001 |pmid= 11262615 |doi=  }}
*{{cite journal  | author=Abdel-Ghany M, Cheng HC, Elble RC, Pauli BU |title=The breast cancer beta 4 integrin and endothelial human CLCA2 mediate lung metastasis. |journal=J. Biol. Chem. |volume=276 |issue= 27 |pages= 25438-46 |year= 2001 |pmid= 11320086 |doi= 10.1074/jbc.M100478200 }}
*{{cite journal  | author=Abdel-Ghany M, Cheng HC, Elble RC, Pauli BU |title=Focal adhesion kinase activated by beta(4) integrin ligation to mCLCA1 mediates early metastatic growth. |journal=J. Biol. Chem. |volume=277 |issue= 37 |pages= 34391-400 |year= 2002 |pmid= 12110680 |doi= 10.1074/jbc.M205307200 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Mall M, Gonska T, Thomas J, ''et al.'' |title=Modulation of Ca2+-activated Cl- secretion by basolateral K+ channels in human normal and cystic fibrosis airway epithelia. |journal=Pediatr. Res. |volume=53 |issue= 4 |pages= 608-18 |year= 2003 |pmid= 12612194 |doi= 10.1203/01.PDR.0000057204.51420.DC }}
*{{cite journal  | author=Abdel-Ghany M, Cheng HC, Elble RC, ''et al.'' |title=The interacting binding domains of the beta(4) integrin and calcium-activated chloride channels (CLCAs) in metastasis. |journal=J. Biol. Chem. |volume=278 |issue= 49 |pages= 49406-16 |year= 2004 |pmid= 14512419 |doi= 10.1074/jbc.M309086200 }}
*{{cite journal  | author=Connon CJ, Kawasaki S, Yamasaki K, ''et al.'' |title=The quantification of hCLCA2 and colocalisation with integrin beta4 in stratified human epithelia. |journal=Acta Histochem. |volume=106 |issue= 6 |pages= 421-5 |year= 2005 |pmid= 15707651 |doi= 10.1016/j.acthis.2004.08.003 }}
*{{cite journal  | author=Connon CJ, Kawasaki S, Liles M, ''et al.'' |title=Gene expression and immunolocalisation of a calcium-activated chloride channel during the stratification of cultivated and developing corneal epithelium. |journal=Cell Tissue Res. |volume=323 |issue= 1 |pages= 177-82 |year= 2006 |pmid= 16158324 |doi= 10.1007/s00441-005-0059-2 }}
*{{cite journal  | author=Elble RC, Walia V, Cheng HC, ''et al.'' |title=The putative chloride channel hCLCA2 has a single C-terminal transmembrane segment. |journal=J. Biol. Chem. |volume=281 |issue= 40 |pages= 29448-54 |year= 2006 |pmid= 16873362 |doi= 10.1074/jbc.M605919200 }}
}}
{{refend}}


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{{gene-1-stub}}
{{WikiDoc Sources}}

Latest revision as of 09:45, 30 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Chloride channel accessory 2 is a protein that in humans is encoded by the CLCA2 gene.[1]

The protein encoded by this gene belongs to the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same site on chromosome 1p31-p22 and share high degrees of homology in size, sequence and predicted structure, but differ significantly in their tissue distributions. Since this protein is expressed predominantly in trachea and lung, it is suggested to play a role in the complex pathogenesis of cystic fibrosis. It may also serve as adhesion molecule for lung metastatic cancer cells, mediating vascular arrest and colonization, and furthermore, it has been implicated to act as a tumor suppressor gene for breast cancer.[1] Protein structure prediction methods suggest the N-terminal region of CLCA2 protein is a zinc metalloprotease.[2]

See also

References

  1. ↑ 1.0 1.1 "Entrez Gene: CLCA2 chloride channel, calcium activated, family member 2".
  2. ↑ Pawłowski K, Lepistö M, Meinander N, et al. (2006). "Novel conserved hydrolase domain in the CLCA family of alleged calcium-activated chloride channels". Proteins. 63 (3): 424–39. doi:10.1002/prot.20887. PMID 16470849.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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