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{{Infobox_gene}}
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'''Chloride channel accessory 1''' is a [[protein]] that in humans is encoded by the ''CLCA1'' [[gene]].<ref name="pmid9828122">{{cite journal | vauthors = Gruber AD, Elble RC, Ji HL, Schreur KD, Fuller CM, Pauli BU | title = Genomic cloning, molecular characterization, and functional analysis of human CLCA1, the first human member of the family of Ca<sup>2+</sup>-activated Cl<sup>−</sup> channel proteins | journal = Genomics | volume = 54 | issue = 2 | pages = 200–14 |date=Jan 1999 | pmid = 9828122 | pmc = | doi = 10.1006/geno.1998.5562 }}</ref><ref name="entrez" />
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Chloride channel, calcium activated, family member 1
| HGNCid = 2015
| Symbol = CLCA1
| AltSymbols =; CaCC
| OMIM = 603906
| ECnumber = 
| Homologene = 984
| MGIid = 1346342
| GeneAtlas_image1 = PBB_GE_CLCA1_210107_at_tn.png
| Function = {{GNF_GO|id=GO:0005254 |text = chloride channel activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}}
| Process = {{GNF_GO|id=GO:0006810 |text = transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1179
    | Hs_Ensembl = ENSG00000016490
    | Hs_RefseqProtein = NP_001276
    | Hs_RefseqmRNA = NM_001285
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 86706639
    | Hs_GenLoc_end = 86738532
    | Hs_Uniprot = 
    | Mm_EntrezGene = 23844
    | Mm_Ensembl = ENSMUSG00000028255
    | Mm_RefseqmRNA = XM_978159
    | Mm_RefseqProtein = XP_983253
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 3
    | Mm_GenLoc_start = 144941923
    | Mm_GenLoc_end = 144970158
    | Mm_Uniprot = 
  }}
}}
'''Chloride channel, calcium activated, family member 1''', also known as '''CLCA1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CLCA1 chloride channel, calcium activated, family member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1179| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes a member of the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same region on chromosome 1p31-p22 and share a high degree of homology in size, sequence, and predicted structure, but differ significantly in their tissue distributions. The encoded protein is expressed as a precursor protein that is processed into two cell-surface-associated subunits, although the site at which the precursor is cleaved has not been precisely determined. The encoded protein may be involved in mediating calcium-activated chloride conductance in the intestine.<ref name="entrez">{{cite web | title = Entrez Gene: CLCA1 chloride channel, calcium activated, family member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1179| accessdate = }}</ref>
| summary_text = This gene encodes a member of the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same region on chromosome 1p31-p22 and share a high degree of homology in size, sequence, and predicted structure, but differ significantly in their tissue distributions. The encoded protein is expressed as a precursor protein that is processed into two cell-surface-associated subunits, although the site at which the precursor is cleaved has not been precisely determined. The encoded protein may be involved in mediating calcium-activated chloride conductance in the intestine.<ref name="entrez">{{cite web | title = Entrez Gene: CLCA1 chloride channel, calcium activated, family member 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1179| accessdate = }}</ref> Protein structure prediction methods suggest the N-terminal region of CLCA1 protein is a zinc [[metalloprotease]].<ref name="pmid16470849">{{cite journal | vauthors=Pawłowski K, Lepistö M, Meinander N |title=Novel conserved hydrolase domain in the CLCA family of alleged calcium-activated chloride channels |journal=Proteins |volume=63 |issue= 3 |pages= 424–39 |year= 2006 |pmid= 16470849|doi= 10.1002/prot.20887|display-authors=etal}}</ref>
}}
}}
==See also==
* [[Chloride channel]]


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Hume JR, Duan D, Collier ML, ''et al.'' |title=Anion transport in heart. |journal=Physiol. Rev. |volume=80 |issue= 1 |pages= 31-81 |year= 2000 |pmid= 10617765 |doi= }}
*{{cite journal | vauthors=Hume JR, Duan D, Collier ML |title=Anion transport in heart |journal=Physiol. Rev. |volume=80 |issue= 1 |pages= 31–81 |year= 2000 |pmid= 10617765 |doi= |display-authors=etal}}
*{{cite journal | author=Pauli BU, Abdel-Ghany M, Cheng HC, ''et al.'' |title=Molecular characteristics and functional diversity of CLCA family members. |journal=Clin. Exp. Pharmacol. Physiol. |volume=27 |issue= 11 |pages= 901-5 |year= 2001 |pmid= 11071307 |doi= }}
*{{cite journal | vauthors=Pauli BU, Abdel-Ghany M, Cheng HC |title=Molecular characteristics and functional diversity of CLCA family members |journal=Clin. Exp. Pharmacol. Physiol. |volume=27 |issue= 11 |pages= 901–5 |year= 2001 |pmid= 11071307 |doi=10.1046/j.1440-1681.2000.03358.x |display-authors=etal}}
*{{cite journal  | author=Gruber AD, Elble RC, Ji HL, ''et al.'' |title=Genomic cloning, molecular characterization, and functional analysis of human CLCA1, the first human member of the family of Ca2+-activated Cl- channel proteins. |journal=Genomics |volume=54 |issue= 2 |pages= 200-14 |year= 1999 |pmid= 9828122 |doi= 10.1006/geno.1998.5562 }}
*{{cite journal | vauthors=Agnel M, Vermat T, Culouscou JM |title=Identification of three novel members of the calcium-dependent chloride channel (CaCC) family predominantly expressed in the digestive tract and trachea |journal=FEBS Lett. |volume=455 |issue= 3 |pages= 295–301 |year= 1999 |pmid= 10437792 |doi=10.1016/S0014-5793(99)00891-1 }}
*{{cite journal | author=Agnel M, Vermat T, Culouscou JM |title=Identification of three novel members of the calcium-dependent chloride channel (CaCC) family predominantly expressed in the digestive tract and trachea. |journal=FEBS Lett. |volume=455 |issue= 3 |pages= 295-301 |year= 1999 |pmid= 10437792 |doi= }}
*{{cite journal | vauthors=Dias Neto E, Correa RG, Verjovski-Almeida S |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491–6 |year= 2000 |pmid= 10737800 |doi=10.1073/pnas.97.7.3491 | pmc=16267 |display-authors=etal}}
*{{cite journal | author=Dias Neto E, Correa RG, Verjovski-Almeida S, ''et al.'' |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491-6 |year= 2000 |pmid= 10737800 |doi= }}
*{{cite journal | vauthors=Liu QH, Williams DA, McManus C |title=HIV-1 gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 9 |pages= 4832–7 |year= 2000 |pmid= 10758170 |doi= 10.1073/pnas.090521697 | pmc=18318 |display-authors=etal}}
*{{cite journal | author=Liu QH, Williams DA, McManus C, ''et al.'' |title=HIV-1 gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 9 |pages= 4832-7 |year= 2000 |pmid= 10758170 |doi= 10.1073/pnas.090521697 }}
*{{cite journal | vauthors=Toda M, Tulic MK, Levitt RC, Hamid Q |title=A calcium-activated chloride channel (HCLCA1) is strongly related to IL-9 expression and mucus production in bronchial epithelium of patients with asthma |journal=J. Allergy Clin. Immunol. |volume=109 |issue= 2 |pages= 246–50 |year= 2002 |pmid= 11842292 |doi=10.1067/mai.2002.121555 }}
*{{cite journal | author=Toda M, Tulic MK, Levitt RC, Hamid Q |title=A calcium-activated chloride channel (HCLCA1) is strongly related to IL-9 expression and mucus production in bronchial epithelium of patients with asthma. |journal=J. Allergy Clin. Immunol. |volume=109 |issue= 2 |pages= 246-50 |year= 2002 |pmid= 11842292 |doi= }}
*{{cite journal | vauthors=Greenwood IA, Miller LJ, Ohya S, Horowitz B |title=The large conductance potassium channel beta-subunit can interact with and modulate the functional properties of a calcium-activated chloride channel, CLCA1 |journal=J. Biol. Chem. |volume=277 |issue= 25 |pages= 22119–22 |year= 2002 |pmid= 11994272 |doi= 10.1074/jbc.C200215200 }}
*{{cite journal | author=Greenwood IA, Miller LJ, Ohya S, Horowitz B |title=The large conductance potassium channel beta-subunit can interact with and modulate the functional properties of a calcium-activated chloride channel, CLCA1. |journal=J. Biol. Chem. |volume=277 |issue= 25 |pages= 22119-22 |year= 2002 |pmid= 11994272 |doi= 10.1074/jbc.C200215200 }}
*{{cite journal | vauthors=Abdel-Ghany M, Cheng HC, Elble RC, Pauli BU |title=Focal adhesion kinase activated by beta(4) integrin ligation to mCLCA1 mediates early metastatic growth |journal=J. Biol. Chem. |volume=277 |issue= 37 |pages= 34391–400 |year= 2002 |pmid= 12110680 |doi= 10.1074/jbc.M205307200 }}
*{{cite journal | author=Abdel-Ghany M, Cheng HC, Elble RC, Pauli BU |title=Focal adhesion kinase activated by beta(4) integrin ligation to mCLCA1 mediates early metastatic growth. |journal=J. Biol. Chem. |volume=277 |issue= 37 |pages= 34391-400 |year= 2002 |pmid= 12110680 |doi= 10.1074/jbc.M205307200 }}
*{{cite journal | vauthors=Loewen ME, Bekar LK, Gabriel SE |title=pCLCA1 becomes a cAMP-dependent chloride conductance mediator in Caco-2 cells |journal=Biochem. Biophys. Res. Commun. |volume=298 |issue= 4 |pages= 531–6 |year= 2002 |pmid= 12408984 |doi=10.1016/S0006-291X(02)02498-1 |display-authors=etal}}
*{{cite journal | author=Loewen ME, Bekar LK, Gabriel SE, ''et al.'' |title=pCLCA1 becomes a cAMP-dependent chloride conductance mediator in Caco-2 cells. |journal=Biochem. Biophys. Res. Commun. |volume=298 |issue= 4 |pages= 531-6 |year= 2002 |pmid= 12408984 |doi= }}
*{{cite journal | vauthors=Zhou Y, Shapiro M, Dong Q |title=A calcium-activated chloride channel blocker inhibits goblet cell metaplasia and mucus overproduction |journal=Novartis Found. Symp. |volume=248 |issue= |pages= 150–65; discussion 165–70, 277–82 |year= 2003 |pmid= 12568493 |doi=10.1002/0470860790.ch10 |display-authors=etal}}
*{{cite journal | author=Zhou Y, Shapiro M, Dong Q, ''et al.'' |title=A calcium-activated chloride channel blocker inhibits goblet cell metaplasia and mucus overproduction. |journal=Novartis Found. Symp. |volume=248 |issue= |pages= 150-65; discussion 165-70, 277-82 |year= 2003 |pmid= 12568493 |doi= }}
*{{cite journal | vauthors=Abdel-Ghany M, Cheng HC, Elble RC |title=The interacting binding domains of the beta(4) integrin and calcium-activated chloride channels (CLCAs) in metastasis |journal=J. Biol. Chem. |volume=278 |issue= 49 |pages= 49406–16 |year= 2004 |pmid= 14512419 |doi= 10.1074/jbc.M309086200 |display-authors=etal}}
*{{cite journal | author=Abdel-Ghany M, Cheng HC, Elble RC, ''et al.'' |title=The interacting binding domains of the beta(4) integrin and calcium-activated chloride channels (CLCAs) in metastasis. |journal=J. Biol. Chem. |volume=278 |issue= 49 |pages= 49406-16 |year= 2004 |pmid= 14512419 |doi= 10.1074/jbc.M309086200 }}
*{{cite journal | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | vauthors=Hegab AE, Sakamoto T, Uchida Y |title=CLCA1 gene polymorphisms in chronic obstructive pulmonary disease |journal=J. Med. Genet. |volume=41 |issue= 3 |pages= e27 |year= 2004 |pmid= 14985398 |doi=10.1136/jmg.2003.012484 | pmc=1735703 |display-authors=etal}}
*{{cite journal | author=Hegab AE, Sakamoto T, Uchida Y, ''et al.'' |title=CLCA1 gene polymorphisms in chronic obstructive pulmonary disease. |journal=J. Med. Genet. |volume=41 |issue= 3 |pages= e27 |year= 2004 |pmid= 14985398 |doi= }}
*{{cite journal | vauthors=Kamada F, Suzuki Y, Shao C |title=Association of the hCLCA1 gene with childhood and adult asthma |journal=Genes Immun. |volume=5 |issue= 7 |pages= 540–7 |year= 2005 |pmid= 15318163 |doi= 10.1038/sj.gene.6364124 |display-authors=etal}}
*{{cite journal | author=Kamada F, Suzuki Y, Shao C, ''et al.'' |title=Association of the hCLCA1 gene with childhood and adult asthma. |journal=Genes Immun. |volume=5 |issue= 7 |pages= 540-7 |year= 2005 |pmid= 15318163 |doi= 10.1038/sj.gene.6364124 }}
*{{cite journal | vauthors=Ritzka M, Stanke F, Jansen S |title=The CLCA gene locus as a modulator of the gastrointestinal basic defect in cystic fibrosis |journal=Hum. Genet. |volume=115 |issue= 6 |pages= 483–91 |year= 2005 |pmid= 15490240 |doi= 10.1007/s00439-004-1190-y |display-authors=etal}}
*{{cite journal | author=Ritzka M, Stanke F, Jansen S, ''et al.'' |title=The CLCA gene locus as a modulator of the gastrointestinal basic defect in cystic fibrosis. |journal=Hum. Genet. |volume=115 |issue= 6 |pages= 483-91 |year= 2005 |pmid= 15490240 |doi= 10.1007/s00439-004-1190-y }}
*{{cite journal | vauthors=Gibson A, Lewis AP, Affleck K |title=hCLCA1 and mCLCA3 are secreted non-integral membrane proteins and therefore are not ion channels |journal=J. Biol. Chem. |volume=280 |issue= 29 |pages= 27205–12 |year= 2005 |pmid= 15919655 |doi= 10.1074/jbc.M504654200 |display-authors=etal}}
*{{cite journal | author=Gibson A, Lewis AP, Affleck K, ''et al.'' |title=hCLCA1 and mCLCA3 are secreted non-integral membrane proteins and therefore are not ion channels. |journal=J. Biol. Chem. |volume=280 |issue= 29 |pages= 27205-12 |year= 2005 |pmid= 15919655 |doi= 10.1074/jbc.M504654200 }}
*{{cite journal | vauthors=Jeong SM, Park HK, Yoon IS |title=Cloning and expression of Ca<sup>2+</sup>-activated chloride channel from rat brain |journal=Biochem. Biophys. Res. Commun. |volume=334 |issue= 2 |pages= 569–76 |year= 2005 |pmid= 16023076 |doi= 10.1016/j.bbrc.2005.06.122 |display-authors=etal}}
*{{cite journal | author=Jeong SM, Park HK, Yoon IS, ''et al.'' |title=Cloning and expression of Ca2+-activated chloride channel from rat brain. |journal=Biochem. Biophys. Res. Commun. |volume=334 |issue= 2 |pages= 569-76 |year= 2005 |pmid= 16023076 |doi= 10.1016/j.bbrc.2005.06.122 }}
}}
}}
{{refend}}
{{refend}}


{{protein-stub}}
==External links==
{{WikiDoc Sources}}
* {{MeshName|CLCA1+protein,+human}}
* {{UCSC gene info|CLCA1}}
 
{{NLM content}}
{{Ion channels|g4}}
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[[Category:Chloride channels]]
 
 
{{gene-1-stub}}

Latest revision as of 02:01, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Chloride channel accessory 1 is a protein that in humans is encoded by the CLCA1 gene.[1][2]

This gene encodes a member of the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same region on chromosome 1p31-p22 and share a high degree of homology in size, sequence, and predicted structure, but differ significantly in their tissue distributions. The encoded protein is expressed as a precursor protein that is processed into two cell-surface-associated subunits, although the site at which the precursor is cleaved has not been precisely determined. The encoded protein may be involved in mediating calcium-activated chloride conductance in the intestine.[2] Protein structure prediction methods suggest the N-terminal region of CLCA1 protein is a zinc metalloprotease.[3]

See also

References

  1. ↑ Gruber AD, Elble RC, Ji HL, Schreur KD, Fuller CM, Pauli BU (Jan 1999). "Genomic cloning, molecular characterization, and functional analysis of human CLCA1, the first human member of the family of Ca2+-activated Cl− channel proteins". Genomics. 54 (2): 200–14. doi:10.1006/geno.1998.5562. PMID 9828122.
  2. ↑ 2.0 2.1 "Entrez Gene: CLCA1 chloride channel, calcium activated, family member 1".
  3. ↑ Pawłowski K, Lepistö M, Meinander N, et al. (2006). "Novel conserved hydrolase domain in the CLCA family of alleged calcium-activated chloride channels". Proteins. 63 (3): 424–39. doi:10.1002/prot.20887. PMID 16470849.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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