Aquaporin 3: Difference between revisions

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{{protein
{{Infobox_gene}}
|Name=aquaporin 3 (Gill blood group)
|caption=
|image=
|width=
|HGNCid=636
|Symbol=AQP3
|AltSymbols=
|EntrezGene=360
|OMIM=600170
|RefSeq=NM_004925
|UniProt=Q92482
|PDB=
|ECnumber=
|Chromosome=9
|Arm=p
|Band=13
|LocusSupplementaryData=
}}
{{SI}}
{{CMG}}


'''Aquaporin 3''' is found in the basolateral cell membrane of principal [[collecting duct]] cells and provides a pathway for water to exit these cells.<ref name="pmid9558461">{{cite journal |vauthors=Sasaki S, Ishibashi K, Marumo F | title = Aquaporin-2 and -3: representatives of two subgroups of the aquaporin family colocalized in the kidney collecting duct |journal=Annu. Rev. Physiol. | volume = 60 | issue = | pages = 199–220 | year = 1998 | pmid = 9558461 |doi=10.1146/annurev.physiol.60.1.199}}</ref> In the kidney, AQP3 is regulated by [[vasopressin]] (ADH).<ref name="pmid9824541">{{cite journal |year=2014|title=Medical Biochemistry |url=https://www.elsevier.com/books/medical-biochemistry/baynes/978-1-4557-4580-7 |journal=Medical Biochemistry |type=Textbook |edition=4 |volume= |issue= |page=346 |pages=|doi=|issn=|pmid=|via=Elsevier |vauthors=Baynes JW, Dominiczak MH}}</ref> This protein is also a determinant for the GIL blood group system.<ref name="pmid12239222">{{cite journal |vauthors=Roudier N, Ripoche P, Gane P, Le Pennec PY, Daniels G, Cartron JP, Bailly P | title = AQP3 deficiency in humans and the molecular basis of a novel blood group system, GIL | journal = J. Biol. Chem. | volume = 277 | issue = 48 | pages = 45854–9 | year = 2002 | pmid = 12239222 | doi = 10.1074/jbc.M208999200}}</ref>


[[Suberoylanilide hydroxamic acid]] (SAHA) (a [[HDAC inhibitor]]) increases expression of aquaporin-3 in normal skin cells ([[keratinocyte]]s).<ref name=MCG2017>[https://medicalxpress.com/news/2017-05-cancer-therapy-psoriasis-treatment.html Cancer therapy shows promise for psoriasis treatment]</ref>


'''Aquaporin 3''' is found in the basolateral cell membrane of principal [[collecting duct]] cells and provide a pathway for water to exit these cells.<ref name="pmid9558461">{{cite journal | author = Sasaki S, Ishibashi K, Marumo F | title = Aquaporin-2 and -3: representatives of two subgroups of the aquaporin family colocalized in the kidney collecting duct | journal = Annu. Rev. Physiol. | volume = 60 | issue = | pages = 199–220 | year = 1998 | pmid = 9558461 | doi = 10.1146/annurev.physiol.60.1.199 | issn = }}</ref> In kidney, AQP3 gene expression is not regulated by [[vasopressin]] (ADH).<ref name="pmid9824541">{{cite journal | author = Dibas AI, Mia AJ, Yorio T | title = Aquaporins (water channels): role in vasopressin-activated water transport | journal = Proc. Soc. Exp. Biol. Med. | volume = 219 | issue = 3 | pages = 183–99 | year = 1998 | pmid = 9824541 | doi = | issn = | url = http://www.ebmonline.org/cgi/content/abstract/219/3/183 }}</ref>  This protein is also a determinant for the GIL blood group system.<ref name="pmid12239222">{{cite journal | author = Roudier N, Ripoche P, Gane P, Le Pennec PY, Daniels G, Cartron JP, Bailly P | title = AQP3 deficiency in humans and the molecular basis of a novel blood group system, GIL | journal = J. Biol. Chem. | volume = 277 | issue = 48 | pages = 45854–9 | year = 2002 | pmid = 12239222 | doi = 10.1074/jbc.M208999200 | issn = }}</ref>
==Clinical significance==
AQP3 levels are often lower in [[psoriasis]] than in healthy skin.<ref name=MCG2017/>
 
AQP3 is expressed more in [[atopic eczema]].<ref>{{cite journal |vauthors=Olsson M, Broberg A, Jernãs M |title=Increased expression of aquaporin 3 in atopic eczema. |journal=Allergy |volume=61 |issue= 9 |pages= 1132–7 |year= 2006 |pmid= 16918518 |doi= 10.1111/j.1398-9995.2006.01151.x |display-authors=etal}}</ref>


==See also==
==See also==
Line 30: Line 15:
==References==
==References==
{{Reflist}}
{{Reflist}}
{{Clear}}
==Further reading==
{{refbegin|35em}}
*{{cite journal |vauthors=Bietz S, Montilla I, Külzer S |title=Recruitment of human aquaporin 3 to internal membranes in the Plasmodium falciparum infected erythrocyte. |journal=Mol. Biochem. Parasitol. |volume=167 |issue= 1 |pages= 48–53 |year= 2009 |pmid= 19393693 |doi= 10.1016/j.molbiopara.2009.04.006 |display-authors=etal}}
*{{cite journal |vauthors=Bahamontes-Rosa N, Tena-Tomás C, Wolkow J |title=Genetic conservation of the GIL blood group determining aquaporin 3 gene in African and Caucasian populations. |journal=Transfusion |volume=48 |issue= 6 |pages= 1164–8 |year= 2008 |pmid= 18435676 |doi= 10.1111/j.1537-2995.2008.01683.x |display-authors=etal}}
*{{cite journal |vauthors=Wang S, Amidi F, Beall M |title=Aquaporin 3 expression in human fetal membranes and its up-regulation by cyclic adenosine monophosphate in amnion epithelial cell culture. |journal=J. Soc. Gynecol. Investig. |volume=13 |issue= 3 |pages= 181–5 |year= 2006 |pmid= 16638588 |doi= 10.1016/j.jsgi.2006.02.002 |display-authors=etal}}
*{{cite journal |vauthors=Ben Y, Chen J, Zhu R |title=Upregulation of AQP3 and AQP5 induced by dexamethasone and ambroxol in A549 cells. |journal=Respiratory physiology & neurobiology |volume=161 |issue= 2 |pages= 111–8 |year= 2008 |pmid= 18280225 |doi= 10.1016/j.resp.2007.12.007 |display-authors=etal}}
*{{cite journal |vauthors=Yasui H, Kubota M, Iguchi K |title=Membrane trafficking of aquaporin 3 induced by epinephrine. |journal=Biochem. Biophys. Res. Commun. |volume=373 |issue= 4 |pages= 613–7 |year= 2008 |pmid= 18601899 |doi= 10.1016/j.bbrc.2008.06.086 |display-authors=etal}}
*{{cite journal |vauthors=Horie I, Maeda M, Yokoyama S |title=Tumor necrosis factor-alpha decreases aquaporin-3 expression in DJM-1 keratinocytes. |journal=Biochem. Biophys. Res. Commun. |volume=387 |issue= 3 |pages= 564–8 |year= 2009 |pmid= 19619514 |doi= 10.1016/j.bbrc.2009.07.077 |display-authors=etal}}
*{{cite journal |vauthors=Bellemère G, Von Stetten O, Oddos T |title=Retinoic acid increases aquaporin 3 expression in normal human skin. |journal=J. Invest. Dermatol. |volume=128 |issue= 3 |pages= 542–8 |year= 2008 |pmid= 17943189 |doi= 10.1038/sj.jid.5701047}}
*{{cite journal |vauthors=Cohly HH, Isokpehi R, Rajnarayanan RV |title=Compartmentalization of aquaporins in the human intestine. |journal=Int J Environ Res Public Health |volume=5 |issue= 2 |pages= 115–9 |year= 2008 |pmid= 18678926 |doi=10.3390/ijerph5020115|pmc=2694936}}
*{{cite journal |vauthors=Lee TC, Ho IC, Lu WJ, Huang JD |title=Enhanced expression of multidrug resistance-associated protein 2 and reduced expression of aquaglyceroporin 3 in an arsenic-resistant human cell line. |journal=J. Biol. Chem. |volume=281 |issue= 27 |pages= 18401–7 |year= 2006 |pmid= 16672223 |doi= 10.1074/jbc.M601266200}}
*{{cite journal |vauthors=Hara-Chikuma M, Verkman AS |title=Aquaporin-3 facilitates epidermal cell migration and proliferation during wound healing. |journal=J. Mol. Med. |volume=86 |issue= 2 |pages= 221–31 |year= 2008 |pmid= 17968524 |doi= 10.1007/s00109-007-0272-4}}
*{{cite journal |vauthors=Hara-Chikuma M, Takahashi K, Chikuma S |title=The expression of differentiation markers in aquaporin-3 deficient epidermis. |journal=Arch. Dermatol. Res. |volume=301 |issue= 3 |pages= 245–52 |year= 2009 |pmid= 19184071 |doi= 10.1007/s00403-009-0927-9 |pmc=3582396|display-authors=etal}}
*{{cite journal |vauthors=Wang J, Tanji N, Kikugawa T |title=Expression of aquaporin 3 in the human prostate. |journal=Int. J. Urol. |volume=14 |issue= 12 |pages= 1088–92; discussion 1092 |year= 2007 |pmid= 18036046 |doi= 10.1111/j.1442-2042.2007.01901.x |display-authors=etal}}
*{{cite journal |vauthors=Higuchi S, Kubota M, Iguchi K |title=Transcriptional regulation of aquaporin 3 by insulin. |journal=J. Cell. Biochem. |volume=102 |issue= 4 |pages= 1051–8 |year= 2007 |pmid= 17471492 |doi= 10.1002/jcb.21350 |display-authors=etal}}
*{{cite journal |vauthors=Tancharoen S, Matsuyama T, Abeyama K |title=The role of water channel aquaporin 3 in the mechanism of TNF-alpha-mediated proinflammatory events: Implication in periodontal inflammation. |journal=J. Cell. Physiol. |volume=217 |issue= 2 |pages= 338–49 |year= 2008 |pmid= 18543247 |doi= 10.1002/jcp.21506 |display-authors=etal}}
*{{cite journal |vauthors=Richardson SM, Knowles R, Marples D |title=Aquaporin expression in the human intervertebral disc. |journal=J. Mol. Histol. |volume=39 |issue= 3 |pages= 303–9 |year= 2008 |pmid= 18247144 |doi= 10.1007/s10735-008-9166-1 |display-authors=etal}}
*{{cite journal |vauthors=Avril-Delplanque A, Casal I, Castillon N |title=Aquaporin-3 expression in human fetal airway epithelial progenitor cells. |journal=Stem Cells |volume=23 |issue= 7 |pages= 992–1001 |year= 2005 |pmid= 16043462 |doi= 10.1634/stemcells.2004-0197 |display-authors=etal}}
*{{cite journal |vauthors=Kida H, Miyoshi T, Manabe K |title=Roles of aquaporin-3 water channels in volume-regulatory water flow in a human epithelial cell line. |journal=J. Membr. Biol. |volume=208 |issue= 1 |pages= 55–64 |year= 2005 |pmid= 16596446 |doi= 10.1007/s00232-005-0819-7 |display-authors=etal}}
*{{cite journal |vauthors=Liu YL, Matsuzaki T, Nakazawa T |title=Expression of aquaporin 3 (AQP3) in normal and neoplastic lung tissues. |journal=Hum. Pathol. |volume=38 |issue= 1 |pages= 171–8 |year= 2007 |pmid= 17056099 |doi= 10.1016/j.humpath.2006.07.015 |display-authors=etal}}
{{refend}}


==External links==
==External links==
* [http://www.ncbi.nlm.nih.gov/projects/mhc/xslcgi.fcgi?cmd=bgmut/systems_info&system=gil GIL blood group system at BGMUT] Blood Group Antigen Gene Mutation Database at [[NCBI]], [[NIH]]
* [https://www.ncbi.nlm.nih.gov/projects/gv/mhc/xslcgi.cgi?cmd=bgmut/systems_info&system=gil GIL blood group system] at [[BGMUT]] Blood Group Antigen Gene Mutation Database at [[National Center for Biotechnology Information|NCBI]], [[NIH]]
* {{UCSC gene info|AQP3}}


{{Ion channels}}
{{Ion channels|g4}}


[[Category:Membrane biology]]
[[Category:Membrane biology]]
[[Category:Integral membrane proteins]]
[[Category:Integral membrane proteins]]
[[Category:Blood]]
[[Category:Blood proteins]]
[[Category:Transfusion medicine]]
[[Category:Transfusion medicine]]
[[Category:Hematology]]
[[Category:Blood antigen systems]]
[[Category:Blood antigen systems]]
{{WH}}
{{WS}}

Latest revision as of 07:44, 10 January 2019

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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
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Aquaporin 3 is found in the basolateral cell membrane of principal collecting duct cells and provides a pathway for water to exit these cells.[1] In the kidney, AQP3 is regulated by vasopressin (ADH).[2] This protein is also a determinant for the GIL blood group system.[3]

Suberoylanilide hydroxamic acid (SAHA) (a HDAC inhibitor) increases expression of aquaporin-3 in normal skin cells (keratinocytes).[4]

Clinical significance

AQP3 levels are often lower in psoriasis than in healthy skin.[4]

AQP3 is expressed more in atopic eczema.[5]

See also

References

  1. ↑ Sasaki S, Ishibashi K, Marumo F (1998). "Aquaporin-2 and -3: representatives of two subgroups of the aquaporin family colocalized in the kidney collecting duct". Annu. Rev. Physiol. 60: 199–220. doi:10.1146/annurev.physiol.60.1.199. PMID 9558461.
  2. ↑ Baynes JW, Dominiczak MH (2014). "Medical Biochemistry". Medical Biochemistry (Textbook) (4 ed.): 346 – via Elsevier.
  3. ↑ Roudier N, Ripoche P, Gane P, Le Pennec PY, Daniels G, Cartron JP, Bailly P (2002). "AQP3 deficiency in humans and the molecular basis of a novel blood group system, GIL". J. Biol. Chem. 277 (48): 45854–9. doi:10.1074/jbc.M208999200. PMID 12239222.
  4. ↑ 4.0 4.1 Cancer therapy shows promise for psoriasis treatment
  5. ↑ Olsson M, Broberg A, Jernãs M, et al. (2006). "Increased expression of aquaporin 3 in atopic eczema". Allergy. 61 (9): 1132–7. doi:10.1111/j.1398-9995.2006.01151.x. PMID 16918518.

Further reading

External links

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