AQP7: Difference between revisions

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{{Infobox_gene}}
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'''Aquaporin-7''' is a [[protein]] that in humans is encoded by the ''AQP7'' [[gene]].<ref name="pmid9252401">{{cite journal |vauthors=Ishibashi K, Kuwahara M, Gu Y, Kageyama Y, Tohsaka A, Suzuki F, Marumo F, Sasaki S | title = Cloning and functional expression of a new water channel abundantly expressed in the testis permeable to water, glycerol, and urea | journal = J Biol Chem | volume = 272 | issue = 33 | pages = 20782–6 |date=Sep 1997 | pmid = 9252401 | pmc =  | doi =10.1074/jbc.272.33.20782 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: AQP7 aquaporin 7| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=364| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Aquaporin 7
| HGNCid = 640
| Symbol = AQP7
| AltSymbols =; AQP7L; AQP9; AQPap; MGC149555; MGC149556
| OMIM = 602974
| ECnumber = 
| Homologene = 48000
| MGIid = 1314647
| GeneAtlas_image1 = PBB_GE_AQP7_206955_at_tn.png
| Function = {{GNF_GO|id=GO:0005215 |text = transporter activity}} {{GNF_GO|id=GO:0015250 |text = water channel activity}} {{GNF_GO|id=GO:0015254 |text = glycerol channel activity}} {{GNF_GO|id=GO:0015288 |text = porin activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0019867 |text = outer membrane}}
| Process = {{GNF_GO|id=GO:0006091 |text = generation of precursor metabolites and energy}} {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0006833 |text = water transport}} {{GNF_GO|id=GO:0007588 |text = excretion}} {{GNF_GO|id=GO:0015793 |text = glycerol transport}}
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 364
    | Hs_Ensembl = ENSG00000165269
    | Hs_RefseqProtein = NP_001161
    | Hs_RefseqmRNA = NM_001170
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 9
    | Hs_GenLoc_start = 33374948
    | Hs_GenLoc_end = 33392517
    | Hs_Uniprot = O14520
    | Mm_EntrezGene = 11832
    | Mm_Ensembl = ENSMUSG00000028427
    | Mm_RefseqmRNA = XM_982564
    | Mm_RefseqProtein = XP_987658
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 41221917
    | Mm_GenLoc_end = 41236641
    | Mm_Uniprot = Q5DX24
  }}
}}
'''Aquaporin 7''', also known as '''AQP7''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: AQP7 aquaporin 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=364| accessdate = }}</ref>


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{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = Aquaporins/major intrinsic protein (MIP) are a family of water-selective membrane channels. Aquaporin 7 has greater sequence similarity with AQP3 and AQP9 and they may be a subfamily. Aquaporin 7 and AQP3 are at the same chromosomal location suggesting that 9p13 may be a site of an aquaporin cluster. Aquaporin 7 facilitates water, glycerol and urea transport. It may play an important role in sperm function.<ref name="entrez">{{cite web | title = Entrez Gene: AQP7 aquaporin 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=364| accessdate = }}</ref>
| summary_text = Aquaporins/major intrinsic protein (MIP) are a family of water-selective membrane channels. Aquaporin 7 has greater sequence similarity with AQP3 and AQP9 and they may be a subfamily. Aquaporin 7 and AQP3 are at the same chromosomal location suggesting that 9p13 may be a site of an aquaporin cluster. Aquaporin 7 facilitates water, glycerol and urea transport. It may play an important role in sperm function.<ref name="entrez" />
}}
}}


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==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
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| citations =  
| citations =  
*{{cite journal  | author=Dibas AI, Mia AJ, Yorio T |title=Aquaporins (water channels): role in vasopressin-activated water transport. |journal=Proc. Soc. Exp. Biol. Med. |volume=219 |issue= 3 |pages= 183-99 |year= 1998 |pmid= 9824541 |doi=  }}
*{{cite journal  |vauthors=Dibas AI, Mia AJ, Yorio T |title=Aquaporins (water channels): role in vasopressin-activated water transport |journal=Proc. Soc. Exp. Biol. Med. |volume=219 |issue= 3 |pages= 183–99 |year= 1998 |pmid= 9824541 |doi=  10.3181/00379727-219-44332}}
*{{cite journal  | author=Ishibashi K, Kuwahara M, Gu Y, ''et al.'' |title=Cloning and functional expression of a new water channel abundantly expressed in the testis permeable to water, glycerol, and urea. |journal=J. Biol. Chem. |volume=272 |issue= 33 |pages= 20782-6 |year= 1997 |pmid= 9252401 |doi=  }}
*{{cite journal  | author=Kuriyama H |title=Molecular cloning and expression of a novel human aquaporin from adipose tissue with glycerol permeability |journal=Biochem. Biophys. Res. Commun. |volume=241 |issue= 1 |pages= 53–8 |year= 1998 |pmid= 9405233 |doi= 10.1006/bbrc.1997.7769 |name-list-format=vanc| author2=Kawamoto S  | author3=Ishida N  | display-authors=3  | last4=Ohno  | first4=Ikko  | last5=Mita  | first5=Shiro  | last6=Matsuzawa  | first6=Yuji  | last7=Matsubara  | first7=Kenichi  | last8=Okubo  | first8=Kousaku }}
*{{cite journal  | author=Kuriyama H, Kawamoto S, Ishida N, ''et al.'' |title=Molecular cloning and expression of a novel human aquaporin from adipose tissue with glycerol permeability. |journal=Biochem. Biophys. Res. Commun. |volume=241 |issue= 1 |pages= 53-8 |year= 1998 |pmid= 9405233 |doi= 10.1006/bbrc.1997.7769 }}
*{{cite journal  | author=Ishibashi K |title=Molecular characterization of human Aquaporin-7 gene and its chromosomal mapping |journal=Biochim. Biophys. Acta |volume=1399 |issue= 1 |pages= 62–6 |year= 1998 |pmid= 9714739 |doi= 10.1016/s0167-4781(98)00094-3|name-list-format=vanc| author2=Yamauchi K  | author3=Kageyama Y  | display-authors=3  | last4=Saito-Ohara  | first4=F  | last5=Ikeuchi  | first5=T  | last6=Marumo  | first6=F  | last7=Sasaki  | first7=S }}
*{{cite journal  | author=Ishibashi K, Yamauchi K, Kageyama Y, ''et al.'' |title=Molecular characterization of human Aquaporin-7 gene and its chromosomal mapping. |journal=Biochim. Biophys. Acta |volume=1399 |issue= 1 |pages= 62-6 |year= 1998 |pmid= 9714739 |doi=  }}
*{{cite journal  |vauthors=Suzuki-Toyota F, Ishibashi K, Yuasa S |title=Immunohistochemical localization of a water channel, aquaporin 7 (AQP7), in the rat testis |journal=Cell Tissue Res. |volume=295 |issue= 2 |pages= 279–85 |year= 1999 |pmid= 9931374 |doi=10.1007/s004410051234 }}
*{{cite journal  | author=Suzuki-Toyota F, Ishibashi K, Yuasa S |title=Immunohistochemical localization of a water channel, aquaporin 7 (AQP7), in the rat testis. |journal=Cell Tissue Res. |volume=295 |issue= 2 |pages= 279-85 |year= 1999 |pmid= 9931374 |doi=  }}
*{{cite journal  | author=Kondo H |title=Human aquaporin adipose (AQPap) gene. Genomic structure, promoter analysis and functional mutation |journal=Eur. J. Biochem. |volume=269 |issue= 7 |pages= 1814–26 |year= 2002 |pmid= 11952783 |doi=10.1046/j.1432-1033.2002.02821.x  |name-list-format=vanc| author2=Shimomura I  | author3=Kishida K  | display-authors=3  | last4=Kuriyama  | first4=Hiroshi  | last5=Makino  | first5=Yasunaka  | last6=Nishizawa  | first6=Hitoshi  | last7=Matsuda  | first7=Morihiro  | last8=Maeda  | first8=Norikazu  | last9=Nagaretani  | first9=Hiroyuki }}
*{{cite journal  | author=Kondo H, Shimomura I, Kishida K, ''et al.'' |title=Human aquaporin adipose (AQPap) gene. Genomic structure, promoter analysis and functional mutation. |journal=Eur. J. Biochem. |volume=269 |issue= 7 |pages= 1814-26 |year= 2002 |pmid= 11952783 |doi=  }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-format=vanc| author2=Suzuki Y  | author3=Nishikawa T  | display-authors=3  | last4=Otsuki  | first4=Tetsuji  | last5=Sugiyama  | first5=Tomoyasu  | last6=Irie  | first6=Ryotaro  | last7=Wakamatsu  | first7=Ai  | last8=Hayashi  | first8=Koji  | last9=Sato  | first9=Hiroyuki }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Humphray SJ |title=DNA sequence and analysis of human chromosome 9 |journal=Nature |volume=429 |issue= 6990 |pages= 369–74 |year= 2004 |pmid= 15164053 |doi= 10.1038/nature02465 | pmc=2734081  |name-list-format=vanc| author2=Oliver K  | author3=Hunt AR  | display-authors=3  | last4=Plumb  | first4=R. W.  | last5=Loveland  | first5=J. E.  | last6=Howe  | first6=K. L.  | last7=Andrews  | first7=T. D.  | last8=Searle  | first8=S.  | last9=Hunt  | first9=S. E. }}
*{{cite journal  | author=Humphray SJ, Oliver K, Hunt AR, ''et al.'' |title=DNA sequence and analysis of human chromosome 9. |journal=Nature |volume=429 |issue= 6990 |pages= 369-74 |year= 2004 |pmid= 15164053 |doi= 10.1038/nature02465 }}
*{{cite journal  | author=Fortna A |title=Lineage-Specific Gene Duplication and Loss in Human and Great Ape Evolution |journal=PLoS Biol. |volume=2 |issue= 7 |pages= E207 |year= 2006 |pmid= 15252450 |doi= 10.1371/journal.pbio.0020207 | pmc=449870  |name-list-format=vanc| author2=Kim Y  | author3=MacLaren E  | display-authors=3  | last4=Marshall  | first4=Kriste  | last5=Hahn  | first5=Gretchen  | last6=Meltesen  | first6=Lynne  | last7=Brenton  | first7=Matthew  | last8=Hink  | first8=Raquel  | last9=Burgers  | first9=Sonya }}
*{{cite journal  | author=Fortna A, Kim Y, MacLaren E, ''et al.'' |title=Lineage-specific gene duplication and loss in human and great ape evolution. |journal=PLoS Biol. |volume=2 |issue= 7 |pages= E207 |year= 2006 |pmid= 15252450 |doi= 10.1371/journal.pbio.0020207 }}
*{{cite journal  |vauthors=Marrades MP, Milagro FI, Martínez JA, Moreno-Aliaga MJ |title=Differential expression of aquaporin 7 in adipose tissue of lean and obese high fat consumers |journal=Biochem. Biophys. Res. Commun. |volume=339 |issue= 3 |pages= 785–9 |year= 2006 |pmid= 16325777 |doi= 10.1016/j.bbrc.2005.11.080 }}
*{{cite journal  | author=Marrades MP, Milagro FI, Martínez JA, Moreno-Aliaga MJ |title=Differential expression of aquaporin 7 in adipose tissue of lean and obese high fat consumers. |journal=Biochem. Biophys. Res. Commun. |volume=339 |issue= 3 |pages= 785-9 |year= 2006 |pmid= 16325777 |doi= 10.1016/j.bbrc.2005.11.080 }}
*{{cite journal  | author=Prudente S |title=A functional variant of the adipocyte glycerol channel aquaporin 7 gene is associated with obesity and related metabolic abnormalities |journal=Diabetes |volume=56 |issue= 5 |pages= 1468–74 |year= 2007 |pmid= 17351148 |doi= 10.2337/db06-1389 |name-list-format=vanc| author2=Flex E  | author3=Morini E  | display-authors=3  | last4=Turchi  | first4=F.  | last5=Capponi  | first5=D.  | last6=De Cosmo  | first6=S.  | last7=Tassi  | first7=V.  | last8=Guida  | first8=V.  | last9=Avogaro  | first9=A. }}
*{{cite journal  | author=Prudente S, Flex E, Morini E, ''et al.'' |title=A functional variant of the adipocyte glycerol channel aquaporin 7 gene is associated with obesity and related metabolic abnormalities. |journal=Diabetes |volume=56 |issue= 5 |pages= 1468-74 |year= 2007 |pmid= 17351148 |doi= 10.2337/db06-1389 }}
*{{cite journal  | author=Ceperuelo-Mallafré V |title=Adipose tissue expression of the glycerol channel aquaporin-7 gene is altered in severe obesity but not in type 2 diabetes |journal=J. Clin. Endocrinol. Metab. |volume=92 |issue= 9 |pages= 3640–5 |year= 2007 |pmid= 17566090 |doi= 10.1210/jc.2007-0531 |name-list-format=vanc| author2=Miranda M  | author3=Chacón MR  | display-authors=3  | last4=Vilarrasa  | first4=N.  | last5=Megia  | first5=A.  | last6=Gutierrez  | first6=C.  | last7=Fernandez-Real  | first7=J. M.  | last8=Gomez  | first8=J. M.  | last9=Caubet  | first9=E. }}
*{{cite journal  | author=Ceperuelo-Mallafré V, Miranda M, Chacón MR, ''et al.'' |title=Adipose tissue expression of the glycerol channel aquaporin-7 gene is altered in severe obesity but not in type 2 diabetes. |journal=J. Clin. Endocrinol. Metab. |volume=92 |issue= 9 |pages= 3640-5 |year= 2007 |pmid= 17566090 |doi= 10.1210/jc.2007-0531 }}
}}
}}
{{refend}}
{{refend}}
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== External links ==
== External links ==
* {{MeshName|AQP7+protein,+human}}
* {{MeshName|AQP7+protein,+human}}
* {{UCSC gene info|AQP7}}
* {{UCSC gene info|AQP9}}


{{membrane-protein-stub}}
{{membrane-protein-stub}}
{{NLM content}}
{{NLM content}}
{{Ion channels}}
{{Ion channels|g4}}
{{WikiDoc Sources}}
 
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Revision as of 18:10, 29 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Aquaporin-7 is a protein that in humans is encoded by the AQP7 gene.[1][2]

Aquaporins/major intrinsic protein (MIP) are a family of water-selective membrane channels. Aquaporin 7 has greater sequence similarity with AQP3 and AQP9 and they may be a subfamily. Aquaporin 7 and AQP3 are at the same chromosomal location suggesting that 9p13 may be a site of an aquaporin cluster. Aquaporin 7 facilitates water, glycerol and urea transport. It may play an important role in sperm function.[2]

See also

References

  1. ↑ Ishibashi K, Kuwahara M, Gu Y, Kageyama Y, Tohsaka A, Suzuki F, Marumo F, Sasaki S (Sep 1997). "Cloning and functional expression of a new water channel abundantly expressed in the testis permeable to water, glycerol, and urea". J Biol Chem. 272 (33): 20782–6. doi:10.1074/jbc.272.33.20782. PMID 9252401.
  2. ↑ 2.0 2.1 "Entrez Gene: AQP7 aquaporin 7".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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