AQP5

Aquaporin 5
Identifiers
Symbols	AQP5 ;
External IDs	Template:OMIM5 Template:MGI HomoloGene: 20398
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Aquaporin 5, also known as AQP5, is a human gene.

Aquaporin 5 (AQP5) is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin 5 plays a role in the generation of saliva, tears and pulmonary secretions. AQP0, AQP2, AQP5, and AQP6 are closely related and all map to 12q13.

See also

• Aquaporin

Further reading

• Verkman AS (2003). "Role of aquaporin water channels in eye function". Exp. Eye Res. 76 (2): 137–43. PMID 12565800.
• Lee MD, Bhakta KY, Raina S; et al. (1996). "The human Aquaporin-5 gene. Molecular characterization and chromosomal localization". J. Biol. Chem. 271 (15): 8599–604. PMID 8621489.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ma T, Yang B, Umenishi F, Verkman AS (1997). "Closely spaced tandem arrangement of AQP2, AQP5, and AQP6 genes in a 27-kilobase segment at chromosome locus 12q13". Genomics. 43 (3): 387–9. doi:10.1006/geno.1997.4836. PMID 9268644.CS1 maint: Multiple names: authors list (link)
• Smith JK, Siddiqui AA, Modica LA; et al. (1999). "Interferon-alpha upregulates gene expression of aquaporin-5 in human parotid glands". J. Interferon Cytokine Res. 19 (8): 929–35. doi:10.1089/107999099313479. PMID 10476940.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kreda SM, Gynn MC, Fenstermacher DA; et al. (2001). "Expression and localization of epithelial aquaporins in the adult human lung". Am. J. Respir. Cell Mol. Biol. 24 (3): 224–34. PMID 11245621.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gresz V, Kwon TH, Hurley PT; et al. (2001). "Identification and localization of aquaporin water channels in human salivary glands". Am. J. Physiol. Gastrointest. Liver Physiol. 281 (1): G247–54. PMID 11408278.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nejsum LN, Kwon TH, Jensen UB; et al. (2002). "Functional requirement of aquaporin-5 in plasma membranes of sweat glands". Proc. Natl. Acad. Sci. U.S.A. 99 (1): 511–6. doi:10.1073/pnas.012588099. PMID 11773623.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Burghardt B, Elkaer ML, Kwon TH; et al. (2003). "Distribution of aquaporin water channels AQP1 and AQP5 in the ductal system of the human pancreas". Gut. 52 (7): 1008–16. PMID 12801959.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chen Z, Wang X, Gao L; et al. (2006). "Regulation of MUC5AC mucin secretion by depletion of AQP5 in SPC-A1 cells". Biochem. Biophys. Res. Commun. 342 (3): 775–81. doi:10.1016/j.bbrc.2006.01.103. PMID 16500622.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sidhaye VK, Güler AD, Schweitzer KS; et al. (2006). "Transient receptor potential vanilloid 4 regulates aquaporin-5 abundance under hypotonic conditions". Proc. Natl. Acad. Sci. U.S.A. 103 (12): 4747–52. doi:10.1073/pnas.0511211103. PMID 16537379.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pedersen PS, Braunstein TH, Jørgensen A; et al. (2007). "Stimulation of aquaporin-5 and transepithelial water permeability in human airway epithelium by hyperosmotic stress". Pflugers Arch. 453 (6): 777–85. doi:10.1007/s00424-006-0157-3. PMID 17043812.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Skowron-zwarg M, Boland S, Caruso N; et al. (2007). "Interleukin-13 interferes with CFTR and AQP5 expression and localization during human airway epithelial cell differentiation". Exp. Cell Res. 313 (12): 2695–702. doi:10.1016/j.yexcr.2007.02.035. PMID 17553491.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• AQP5+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.