Calsenilin
| Kv channel interacting protein 3, calsenilin | |||||||||||
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| Identifiers | |||||||||||
| Symbols | KCNIP3 ; CSEN; DREAM; KCHIP3; MGC18289 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 8382 | ||||||||||
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| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
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| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
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Kv channel interacting protein 3, calsenilin, also known as KCNIP3, is a human gene.[1]
This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Alternatively spliced transcript variants encoding different isoforms have been described.[1]
See also
References
Further reading
- Buxbaum JD, Choi EK, Luo Y; et al. (1998). "Calsenilin: a calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragment". Nat. Med. 4 (10): 1177–81. doi:10.1038/2673. PMID 9771752.
- Carrión AM, Mellström B, Naranjo JR (1998). "Protein kinase A-dependent derepression of the human prodynorphin gene via differential binding to an intragenic silencer element". Mol. Cell. Biol. 18 (12): 6921–9. PMID 9819380.
- Carrión AM, Link WA, Ledo F; et al. (1999). "DREAM is a Ca2+-regulated transcriptional repressor". Nature. 398 (6722): 80–4. doi:10.1038/18044. PMID 10078534.
- An WF, Bowlby MR, Betty M; et al. (2000). "Modulation of A-type potassium channels by a family of calcium sensors". Nature. 403 (6769): 553–6. doi:10.1038/35000592. PMID 10676964.
- Leissring MA, Yamasaki TR, Wasco W; et al. (2000). "Calsenilin reverses presenilin-mediated enhancement of calcium signaling". Proc. Natl. Acad. Sci. U.S.A. 97 (15): 8590–3. PMID 10900016.
- Buxbaum JD, Lilliehook C, Chan JY; et al. (2000). "Genomic structure, expression pattern, and chromosomal localization of the human calsenilin gene: no association between an exonic polymorphism and Alzheimer's disease". Neurosci. Lett. 294 (3): 135–8. PMID 11072133.
- Ledo F, Carrión AM, Link WA; et al. (2001). "DREAM-alphaCREM interaction via leucine-charged domains derepresses downstream regulatory element-dependent transcription". Mol. Cell. Biol. 20 (24): 9120–6. PMID 11094064.
- Jo DG, Kim MJ, Choi YH; et al. (2001). "Pro-apoptotic function of calsenilin/DREAM/KChIP3". FASEB J. 15 (3): 589–91. doi:10.1096/fj.00-0541fje. PMID 11259376.
- Choi EK, Zaidi NF, Miller JS; et al. (2001). "Calsenilin is a substrate for caspase-3 that preferentially interacts with the familial Alzheimer's disease-associated C-terminal fragment of presenilin 2". J. Biol. Chem. 276 (22): 19197–204. doi:10.1074/jbc.M008597200. PMID 11278424.
- Osawa M, Tong KI, Lilliehook C; et al. (2001). "Calcium-regulated DNA binding and oligomerization of the neuronal calcium-sensing protein, calsenilin/DREAM/KChIP3". J. Biol. Chem. 276 (44): 41005–13. doi:10.1074/jbc.M105842200. PMID 11535596.
- Cheng HY, Pitcher GM, Laviolette SR; et al. (2002). "DREAM is a critical transcriptional repressor for pain modulation". Cell. 108 (1): 31–43. PMID 11792319.
- Lilliehook C, Chan S, Choi EK; et al. (2002). "Calsenilin enhances apoptosis by altering endoplasmic reticulum calcium signaling". Mol. Cell. Neurosci. 19 (4): 552–9. doi:10.1006/mcne.2001.1096. PMID 11988022.
- Takimoto K, Yang EK, Conforti L (2002). "Palmitoylation of KChIP splicing variants is required for efficient cell surface expression of Kv4.3 channels". J. Biol. Chem. 277 (30): 26904–11. doi:10.1074/jbc.M203651200. PMID 12006572.
- Ledo F, Kremer L, Mellström B, Naranjo JR (2002). "Ca2+-dependent block of CREB-CBP transcription by repressor DREAM". EMBO J. 21 (17): 4583–92. PMID 12198160.
- Zaidi NF, Berezovska O, Choi EK; et al. (2002). "Biochemical and immunocytochemical characterization of calsenilin in mouse brain". Neuroscience. 114 (1): 247–63. PMID 12207970.
- Sanz C, Horita M, Fernandez-Luna JL (2004). "Fas signaling and blockade of Bcr-Abl kinase induce apoptotic Hrk protein via DREAM inhibition in human leukemia cells". Haematologica. 87 (9): 903–7. PMID 12217801.
- Schrader LA, Anderson AE, Mayne A; et al. (2002). "PKA modulation of Kv4.2-encoded A-type potassium channels requires formation of a supramolecular complex". J. Neurosci. 22 (23): 10123–33. PMID 12451113.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Hong YM, Jo DG, Lee MC; et al. (2003). "Reduced expression of calsenilin/DREAM/KChIP3 in the brains of kainic acid-induced seizure and epilepsy patients". Neurosci. Lett. 340 (1): 33–6. PMID 12648752.
- Shibata R, Misonou H, Campomanes CR; et al. (2003). "A fundamental role for KChIPs in determining the molecular properties and trafficking of Kv4.2 potassium channels". J. Biol. Chem. 278 (38): 36445–54. doi:10.1074/jbc.M306142200. PMID 12829703.
External links
- KCNIP3+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.