Hepatocyte nuclear factor 3-beta (HNF-3B), also known as forkhead box protein A2 (FOXA2) or transcription factor 3B (TCF-3B) is a protein that in humans is encoded by the FOXA2gene.[1][2][3]
Forkhead box protein A2 is a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific genes such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. This gene has been linked to sporadic cases of maturity onset diabetes of the young. Transcript variants encoding different isoforms have been identified for this gene.[1]
↑Mincheva A, Lichter P, Schütz G, Kaestner KH (February 1997). "Assignment of the human genes for hepatocyte nuclear factor 3-alpha, -beta, and -gamma (HNF3A, HNF3B, HNF3G) to 14q12-q13, 20p11, and 19q13.2-q13.4". Genomics. 39 (3): 417–9. doi:10.1006/geno.1996.4477. PMID9119385.
↑Wang H, Gauthier BR, Hagenfeldt-Johansson KA, Iezzi M, Wollheim CB (May 2002). "Foxa2 (HNF3beta ) controls multiple genes implicated in metabolism-secretion coupling of glucose-induced insulin release". J. Biol. Chem. 277 (20): 17564–70. doi:10.1074/jbc.M111037200. PMID11875061.
Tabassum R, Chavali S, Dwivedi OP, et al. (2008). "Genetic variants of FOXA2: risk of type 2 diabetes and effect on metabolic traits in North Indians". J. Hum. Genet. 53 (11–12): 957–65. doi:10.1007/s10038-008-0335-6. PMID18797817.
Long Y, Chen E, Liu C, et al. (2009). "The correlation of hepatocyte nuclear factor 4 alpha and 3 beta with hepatitis B virus replication in the liver of chronic hepatitis B patients". J. Viral Hepat. 16 (8): 537–46. doi:10.1111/j.1365-2893.2009.01089.x. PMID19302415.
Ishii K, Yoshida Y, Akechi Y, et al. (2008). "Hepatic differentiation of human bone marrow-derived mesenchymal stem cells by tetracycline-regulated hepatocyte nuclear factor 3beta". Hepatology. 48 (2): 597–606. doi:10.1002/hep.22362. PMID18666263.
Pandey AK, Bhardwaj V, Datta M (2009). "Tumour necrosis factor-alpha attenuates insulin action on phosphoenolpyruvate carboxykinase gene expression and gluconeogenesis by altering the cellular localization of Foxa2 in HepG2 cells". FEBS J. 276 (14): 3757–69. doi:10.1111/j.1742-4658.2009.07091.x. PMID19769745.
Uetzmann L, Burtscher I, Lickert H (2008). "A mouse line expressing Foxa2-driven Cre recombinase in node, notochord, floorplate, and endoderm". Genesis. 46 (10): 515–22. doi:10.1002/dvg.20410. PMID18798232.