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External IDsGeneCards: [1]
RefSeq (mRNA)



RefSeq (protein)



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Homeobox protein Nkx-2.2 is a protein that in humans is encoded by the NKX2-2 gene.[1][2][3]

Homeobox protein Nkx-2.2 contains a homeobox domain and may be involved in the morphogenesis of the central nervous system. This gene is found on chromosome 20 near NKX2-4, and these two genes appear to be duplicated on chromosome 14 in the form of TITF1 and NKX2-8. The encoded protein is likely to be a nuclear transcription factor.[3]

The expression of Nkx2-2 is regulated by an antisense RNA called Nkx2-2as.[4]

In the developing spinal cord, Nkx-2.2 regulates IRX3 thereby contributing to the proper differentiation of the ventral horn neurons.[5]


  1. Furuta H, Horikawa Y, Iwasaki N, Hara M, Sussel L, Le Beau MM, Davis EM, Ogata M, Iwamoto Y, German MS, Bell GI (Aug 1998). "Beta-cell transcription factors and diabetes: mutations in the coding region of the BETA2/NeuroD1 (NEUROD1) and Nkx2.2 (NKX2B) genes are not associated with maturity-onset diabetes of the young in Japanese". Diabetes. 47 (8): 1356–8. doi:10.2337/diabetes.47.8.1356. PMID 9703340.
  2. Price M, Lazzaro D, Pohl T, Mattei MG, Rüther U, Olivo JC, Duboule D, Di Lauro R (Feb 1992). "Regional expression of the homeobox gene Nkx-2.2 in the developing mammalian forebrain". Neuron. 8 (2): 241–55. doi:10.1016/0896-6273(92)90291-K. PMID 1346742.
  3. 3.0 3.1 "Entrez Gene: NKX2-2 NK2 transcription factor related, locus 2 (Drosophila)".
  4. Tochitani S, Hayashizaki Y (Aug 2008). "Nkx2.2 antisense RNA overexpression enhanced oligodendrocytic differentiation". Biochemical and Biophysical Research Communications. 372 (4): 691–6. doi:10.1016/j.bbrc.2008.05.127. PMID 18538132.
  5. Lovrics A, Gao Y, Juhász B, Bock I, Byrne HM, Dinnyés A, Kovács KA (November 2014). "Boolean modelling reveals new regulatory connections between transcription factors orchestrating the development of the ventral spinal cord". PLOS ONE. 9 (11): e111430. doi:10.1371/journal.pone.0111430. PMC 4232242. PMID 25398016.

Further reading

  • Hessabi B, Schmidt I, Walther R (Apr 2000). "The homeodomain of Nkx2.2 carries two cooperatively acting nuclear localization signals". Biochemical and Biophysical Research Communications. 270 (3): 695–700. doi:10.1006/bbrc.2000.2491. PMID 10772886.
  • Wang CC, Brodnicki T, Copeland NG, Jenkins NA, Harvey RP (Jun 2000). "Conserved linkage of NK-2 homeobox gene pairs Nkx2-2/2-4 and Nkx2-1/2-9 in mammals". Mammalian Genome. 11 (6): 466–8. doi:10.1007/s003350010089. PMID 10818213.
  • Sun T, Dong H, Wu L, Kane M, Rowitch DH, Stiles CD (Oct 2003). "Cross-repressive interaction of the Olig2 and Nkx2.2 transcription factors in developing neural tube associated with formation of a specific physical complex". The Journal of Neuroscience. 23 (29): 9547–56. PMID 14573534.
  • Smith R, Owen LA, Trem DJ, Wong JS, Whangbo JS, Golub TR, Lessnick SL (May 2006). "Expression profiling of EWS/FLI identifies NKX2.2 as a critical target gene in Ewing's sarcoma". Cancer Cell. 9 (5): 405–16. doi:10.1016/j.ccr.2006.04.004. PMID 16697960.
  • Pauls S, Zecchin E, Tiso N, Bortolussi M, Argenton F (Apr 2007). "Function and regulation of zebrafish nkx2.2a during development of pancreatic islet and ducts". Developmental Biology. 304 (2): 875–90. doi:10.1016/j.ydbio.2007.01.024. PMID 17335795.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.