MLL (gene)

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Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila), also known as MLL, is a human gene.

MLL is a histone methyltransferase deemed a positive global regulator of gene transcription. This protein belongs to the group of histone-modifying enzymes and is involved in the epigenetic maintenance of transcriptional memory and the pathogenesis of human leukemias.[1] It also may participate in the process of GAD67 downregulation in schizophrenia.[2]


  1. Guenther MG, Jenner RG, Chevalier B, Nakamura T, Croce CM, Canaani E, Young RA (2005). "Global and Hox-specific roles for the MLL1 methyltransferase". Proc. Natl. Acad. Sci. U.S.A. 102 (24): 8603–8. doi:10.1073/pnas.0503072102. PMID 15941828. free fulltext
  2. Huang HS, Matevossian A, Whittle C, Kim SY, Schumacher A, Baker SP, Akbarian S (2007). "Prefrontal dysfunction in schizophrenia involves mixed-lineage leukemia 1-regulated histone methylation at GABAergic gene promoters". J. Neurosci. 27 (42): 11254–62. doi:10.1523/JNEUROSCI.3272-07.2007. PMID 17942719. commented at

Further reading

  • Marschalek R, Nilson I, Löchner K; et al. (1998). "The structure of the human ALL-1/MLL/HRX gene". Leuk. Lymphoma. 27 (5–6): 417–28. PMID 9477123.
  • Eguchi M, Eguchi-Ishimae M, Greaves M (2004). "The role of the MLL gene in infant leukemia". Int. J. Hematol. 78 (5): 390–401. PMID 14704031.
  • Daser A, Rabbitts TH (2004). "Extending the repertoire of the mixed-lineage leukemia gene MLL in leukemogenesis". Genes Dev. 18 (9): 965–74. doi:10.1101/gad.1195504. PMID 15132992.
  • Li ZY, Liu DP, Liang CC (2005). "New insight into the molecular mechanisms of MLL-associated leukemia". Leukemia. 19 (2): 183–90. doi:10.1038/sj.leu.2403602. PMID 15618964.
  • Douet-Guilbert N, Morel F, Le Bris MJ; et al. (2005). "Rearrangement of MLL in a patient with congenital acute monoblastic leukemia and granulocytic sarcoma associated with a t(1;11)(p36;q23) translocation". Leuk. Lymphoma. 46 (1): 143–6. doi:10.1080/104281904000010783. PMID 15621793.

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