QT prolongation: Difference between revisions

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===Common Causes===
===Common Causes===
====Drugs====
====Drugs====
Drug induced QT prolongation is usually a result of treatment by [[Antiarrhythmic agent|anti-arrhythmic]] drugs such as [[amiodarone]] or a number of other drugs that have been reported to cause this problem (e.g. [[cisapride]]).  Some [[anti-psychotic]] drugs, such as [[Haloperidol]] and [[Ziprasidone]], have a prolonged QT interval as a rare side effect. Genetic mutations may make one more susceptible to drug induced QT prolongation.
Drug induced QT prolongation is usually a result of treatment by [[Antiarrhythmic agent|anti-arrhythmic]] drugs or a number of other drugs that have been reported to cause this problem (e.g. [[cisapride]]).  Some [[anti-psychotic]] drugs, such as [[Haloperidol]] and [[Ziprasidone]], have a prolonged QT interval as a rare side effect. Genetic mutations may make one more susceptible to drug induced QT prolongation.


====Long QT Syndrome====
====Long QT Syndrome====

Revision as of 02:20, 2 October 2012

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Synonyms and keywords: Prolonged QT; prolonged QT interval; QT interval prolongation

Overview

QT prolongation refers to a prolongation of the interval on the electrocardiogram during which time the ventricles depolarize and repolarize. QT prolongation is often caused by drugs, genetic abnormalities, and electrolyte disturbances. QT prolongation may predispose the patient to ventricular arrhythmias and sudden cardiac death. Long QT syndrome is one of the many causes of QT prolongation, and is an inherited channelopathy associated with sudden cardiac death.

Causes

Common Causes

Drugs

Drug induced QT prolongation is usually a result of treatment by anti-arrhythmic drugs or a number of other drugs that have been reported to cause this problem (e.g. cisapride). Some anti-psychotic drugs, such as Haloperidol and Ziprasidone, have a prolonged QT interval as a rare side effect. Genetic mutations may make one more susceptible to drug induced QT prolongation.

Long QT Syndrome

Genetic abnormalities cause the Long QT Syndrome.

Electrolyte Disturbances

Electrolyte disturbances such as hyperkalaemia, hypocalcaemia, hypoglycaemia, hypokalaemia, and hypomagnesemia can cause QT prolongation.

Neurologic Events

Subarachnoid hemorrhage and other intracranial events can cause QT prolongation. Widely slayed cerebral T waves are often seen as well.

Anorexia Nervosa

Anorexia nervosa and starvation can cause QT prolongation.

Causes by Organ System

Cardiovascular Ischaemic heart disease, Long QT syndrome, Andersen cardiodysrhythmic periodic paralysis, Jervell and Lange-Nielsen syndrome, Romano-Ward syndrome, Timothy syndrome
Chemical / poisoning Arsenicals
Dermatologic No underlying causes
Drug Side Effect Alimemazine, Almokalant, Amiodarone, Amitriptyline, Arsenic trioxide, Asenapine, Astemizole, Azimilide, Azithromycin, Bepridil, Bretylium, Budipine, Chloroquine, Cibenzoline, Cisapride, Citalopram, Clomipramine, Clozapine, Crizotinib, Desipramine, Diphenhydramine, Disopyramide, Dofetilide, Dolasetron, Doxepin, Dronedarone, Droperidol, Eribulin mesylate, Fluconazole, Grepafloxacin, Halofantrine, Haloperidol, Ibutilide, Imipramine, Indapamide, Ketanserin, Ketoconazole, Lidoflazine, Lubeluzole, Methadone, Methadyl acetate, Midodrine, Mizolastine, Moxifloxacin, Naratriptan, Nicardipine, Nilotinib, Ondansetron, Pasireotide, Pazopanib, Pentamidine, Pimozide, Piperaquine, Prenylamine, Probucol, Procainamide, Propoxyphene, Quinidine, Quinine, Ranolazine, Retigabine, Ritodrine, Ritonavir, Saquinavir, Sertindole, Sotalol, Sparfloxacin, Tedisamil, Telithromycin, Terfenadine, Terodiline, Tetrabenazine, Thioridazine, Vandetanib, Vemurafenib, Venlafaxine, Vernakalant, Voriconazole, Vorinostat, Ziprasidone, Zotepine, Zuclopenthixol
Ear Nose Throat No underlying causes
Endocrine Hypothyroidism
Environmental Zero gravity
Gastroenterologic No underlying causes
Genetic Andersen cardiodysrhythmic periodic paralysis, Jervell and Lange-Nielsen syndrome, Long QT syndrome, Myotonic dystrophy, Romano-Ward syndrome, Timothy syndrome
Hematologic No underlying causes
Iatrogenic No underlying causes
Infectious Disease No underlying causes
Musculoskeletal / Ortho Myotonic dystrophy, Andersen cardiodysrhythmic periodic paralysis, Timothy syndrome
Neurologic Subarachnoid hemorrhage
Nutritional / Metabolic Acute starvation, Anorexia nervosa, Hyperkalaemia, Hypocalcaemia, Hypoglycaemia, Hypokalaemia, Hypomagnesemia
Obstetric/Gynecologic No underlying causes
Oncologic No underlying causes
Opthalmologic No underlying causes
Overdose / Toxicity Alimemazine, Almokalant, Amiodarone, Amitriptyline, Arsenic trioxide, Asenapine, Astemizole, Azimilide, Azithromycin, Bepridil, Bretylium, Budipine, Chloroquine, Cibenzoline, Cisapride, Citalopram, Clomipramine, Clozapine, Crizotinib, Desipramine, Diphenhydramine, Disopyramide, Dofetilide, Dolasetron, Doxepin, Dronedarone, Droperidol, Eribulin mesylate, Fluconazole, Grepafloxacin, Halofantrine, Haloperidol, Ibutilide, Imipramine, Indapamide, Ketanserin, Ketoconazole, Lidoflazine, Lubeluzole, Methadone, Methadyl acetate, Midodrine, Mizolastine, Moxifloxacin, Naratriptan, Nicardipine, Nilotinib, Ondansetron, Pasireotide, Pazopanib, Pentamidine, Pimozide, Piperaquine, Prenylamine, Probucol, Procainamide, Propoxyphene, Quinidine, Quinine, Ranolazine, Retigabine, Ritodrine, Ritonavir, Saquinavir, Sertindole, Sotalol, Sparfloxacin, Tedisamil, Telithromycin, Terfenadine, Terodiline, Tetrabenazine, Thioridazine, Vandetanib, Vemurafenib, Venlafaxine, Vernakalant, Voriconazole, Vorinostat, Ziprasidone, Zotepine, Zuclopenthixol
Psychiatric Anorexia nervosa, Timothy syndrome
Pulmonary No underlying causes
Renal / Electrolyte No underlying causes
Rheum / Immune / Allergy No underlying causes
Sexual No underlying causes
Trauma No underlying causes
Urologic No underlying causes
Dental No underlying causes
Miscellaneous Hypothermia, Acute starvation

Causes in Alphabetical Order


Diagnosis

Electrocardiogram

Shown below is an example of ECG demonstrating QT prolongation with a duration of 600 ms in lead II.


Treatment

In general, treatment involves reversing the underlying cause of the QT prolongation. Electrolytes should be repleted, and consideration should be given to withdrawing offending drugs.

References