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{{Infobox_gene}}
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'''Chloride intracellular channel protein 1''' is a [[protein]] that in humans is encoded by the ''CLIC1'' [[gene]].<ref name="pmid9139710">{{cite journal | vauthors = Valenzuela SM, Martin DK, Por SB, Robbins JM, Warton K, Bootcov MR, Schofield PR, Campbell TJ, Breit SN | title = Molecular cloning and expression of a chloride ion channel of cell nuclei | journal = J Biol Chem | volume = 272 | issue = 19 | pages = 12575–82 |date=Jun 1997 | pmid = 9139710 | doi =10.1074/jbc.272.19.12575 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CLIC1 chloride intracellular channel 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1192| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_CLIC1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1k0m.
| PDB = {{PDB2|1k0m}}, {{PDB2|1k0n}}, {{PDB2|1k0o}}, {{PDB2|1rk4}}
| Name = Chloride intracellular channel 1
| HGNCid = 2062
| Symbol = CLIC1
| AltSymbols =; G6; NCC27
| OMIM = 602872
| ECnumber =
| Homologene = 20343
| MGIid = 2148924
| GeneAtlas_image1 = PBB_GE_CLIC1_208659_at_tn.png
| Function = {{GNF_GO|id=GO:0005247 |text = voltage-gated chloride channel activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0031404 |text = chloride ion binding}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005625 |text = soluble fraction}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005635 |text = nuclear envelope}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005903 |text = brush border}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006821 |text = chloride transport}} {{GNF_GO|id=GO:0007165 |text = signal transduction}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1192
    | Hs_Ensembl = ENSG00000096238
    | Hs_RefseqProtein = NP_001279
    | Hs_RefseqmRNA = NM_001288
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = c6_COX
    | Hs_GenLoc_start = 31833027
    | Hs_GenLoc_end = 31839766
    | Hs_Uniprot = O00299
    | Mm_EntrezGene = 114584
    | Mm_Ensembl = ENSMUSG00000007041
    | Mm_RefseqmRNA = NM_033444
    | Mm_RefseqProtein = NP_254279
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 17
    | Mm_GenLoc_start = 34658299
    | Mm_GenLoc_end = 34666783
    | Mm_Uniprot = Q3TIP8
  }}
}}
'''Chloride intracellular channel 1''', also known as '''CLIC1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CLIC1 chloride intracellular channel 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1192| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity.<ref name="entrez">{{cite web | title = Entrez Gene: CLIC1 chloride intracellular channel 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1192| accessdate = }}</ref>
| summary_text = Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of [[intracellular pH]], and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity.<ref name="entrez" />
}}
}}
==Interactions==
CLIC1 has been shown to [[Protein-protein interaction|interact]] with [[TRAPPC2]].<ref name=pmid12681486>{{cite journal |last=Fan |first=Libin |author2=Yu Wei |author3=Zhu Xueliang  |date=Apr 2003 |title=Interaction of Sedlin with chloride intracellular channel proteins |journal=FEBS Lett. |volume=540 |issue=1–3 |pages=77–80 |publisher= |location = Netherlands| issn = 0014-5793| pmid = 12681486 |doi=10.1016/S0014-5793(03)00228-X }}</ref>
==See also==
* [[Chloride channel]]


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Okubo K, Hori N, Matoba R, ''et al.'' |title=Large scale cDNA sequencing for analysis of quantitative and qualitative aspects of gene expression. |journal=Nat. Genet. |volume=2 |issue= 3 |pages= 173-9 |year= 1994 |pmid= 1345164 |doi= 10.1038/ng1192-173 }}
*{{cite journal  | author=Singh H |title=Two decades with dimorphic Chloride Intracellular Channels (CLICs) |journal=FEBS Letters|volume= 584|issue= 10|pages= 2112–21|year= 2010 |pmid= 20226783 |doi=10.1016/j.febslet.2010.03.013 }}
*{{cite journal | author=Frigerio JM, Berthézène P, Garrido P, ''et al.'' |title=Analysis of 2166 clones from a human colorectal cancer cDNA library by partial sequencing. |journal=Hum. Mol. Genet. |volume=4 |issue= 1 |pages= 37-43 |year= 1995 |pmid= 7711732 |doi= }}
*{{cite journal | vauthors=Okubo K, Hori N, Matoba R |title=Large scale cDNA sequencing for analysis of quantitative and qualitative aspects of gene expression |journal=Nat. Genet. |volume=2 |issue= 3 |pages= 173–9 |year= 1994 |pmid= 1345164 |doi= 10.1038/ng1192-173 |display-authors=etal}}
*{{cite journal | author=Liew CC, Hwang DM, Fung YW, ''et al.'' |title=A catalogue of genes in the cardiovascular system as identified by expressed sequence tags. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 22 |pages= 10645-9 |year= 1994 |pmid= 7938007 |doi= }}
*{{cite journal | vauthors=Frigerio JM, Berthézène P, Garrido P |title=Analysis of 2166 clones from a human colorectal cancer cDNA library by partial sequencing |journal=Hum. Mol. Genet. |volume=4 |issue= 1 |pages= 37–43 |year= 1995 |pmid= 7711732 |doi=10.1093/hmg/4.1.37 |display-authors=etal}}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
*{{cite journal | vauthors=Singh H, Ashley RH |title=Redox Regulation of CLIC1 by Cysteine Residues Associated with the Putative Channel Pore |journal=Biophys. J.|volume=90 |issue= 5 |pages= 1628–1638 |year= 2006 |pmid= 16339885 |doi=10.1529/biophysj.105.072678 | pmc=1367314 }}
*{{cite journal | author=Valenzuela SM, Martin DK, Por SB, ''et al.'' |title=Molecular cloning and expression of a chloride ion channel of cell nuclei. |journal=J. Biol. Chem. |volume=272 |issue= 19 |pages= 12575-82 |year= 1997 |pmid= 9139710 |doi= }}
*{{cite journal | vauthors=Liew CC, Hwang DM, Fung YW |title=A catalogue of genes in the cardiovascular system as identified by expressed sequence tags |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 22 |pages= 10645–9 |year= 1994 |pmid= 7938007 |doi=10.1073/pnas.91.22.10645 | pmc=45078 |display-authors=etal}}
*{{cite journal | author=Heiss NS, Poustka A |title=Genomic structure of a novel chloride channel gene, CLIC2, in Xq28. |journal=Genomics |volume=45 |issue= 1 |pages= 224-8 |year= 1997 |pmid= 9339381 |doi= 10.1006/geno.1997.4922 }}
*{{cite journal | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
*{{cite journal | vauthors=Heiss NS, Poustka A |title=Genomic structure of a novel chloride channel gene, CLIC2, in Xq28 |journal=Genomics |volume=45 |issue= 1 |pages= 224–8 |year= 1997 |pmid= 9339381 |doi= 10.1006/geno.1997.4922 }}
*{{cite journal | author=Tulk BM, Edwards JC |title=NCC27, a homolog of intracellular Cl- channel p64, is expressed in brush border of renal proximal tubule. |journal=Am. J. Physiol. |volume=274 |issue= 6 Pt 2 |pages= F1140-9 |year= 1998 |pmid= 9841507 |doi= }}
*{{cite journal | vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |display-authors=etal}}
*{{cite journal | author=Chuang JZ, Milner TA, Zhu M, Sung CH |title=A 29 kDa intracellular chloride channel p64H1 is associated with large dense-core vesicles in rat hippocampal neurons. |journal=J. Neurosci. |volume=19 |issue= 8 |pages= 2919-28 |year= 1999 |pmid= 10191309 |doi=  }}
*{{cite journal | vauthors=Tulk BM, Edwards JC |title=NCC27, a homolog of intracellular Cl<sup>−</sup> channel p64, is expressed in brush border of renal proximal tubule |journal=Am. J. Physiol. |volume=274 |issue= 6 Pt 2 |pages= F1140–9 |year= 1998 |pmid= 9841507 }}
*{{cite journal | author=Ribas G, Neville M, Wixon JL, ''et al.'' |title=Genes encoding three new members of the leukocyte antigen 6 superfamily and a novel member of Ig superfamily, together with genes encoding the regulatory nuclear chloride ion channel protein (hRNCC) and an N omega-N omega-dimethylarginine dimethylaminohydrolase homologue, are found in a 30-kb segment of the MHC class III region. |journal=J. Immunol. |volume=163 |issue= 1 |pages= 278-87 |year= 1999 |pmid= 10384126 |doi=  }}
*{{cite journal | vauthors=Chuang JZ, Milner TA, Zhu M, Sung CH |title=A 29 kDa intracellular chloride channel p64H1 is associated with large dense-core vesicles in rat hippocampal neurons |journal=J. Neurosci. |volume=19 |issue= 8 |pages= 2919–28 |year= 1999 |pmid= 10191309}}
*{{cite journal | author=Berryman M, Bretscher A |title=Identification of a novel member of the chloride intracellular channel gene family (CLIC5) that associates with the actin cytoskeleton of placental microvilli. |journal=Mol. Biol. Cell |volume=11 |issue= 5 |pages= 1509-21 |year= 2000 |pmid= 10793131 |doi= }}
*{{cite journal | vauthors=Ribas G, Neville M, Wixon JL |title=Genes encoding three new members of the leukocyte antigen 6 superfamily and a novel member of Ig superfamily, together with genes encoding the regulatory nuclear chloride ion channel protein (hRNCC) and an N omega-N omega-dimethylarginine dimethylaminohydrolase homologue, are found in a 30-kb segment of the MHC class III region |journal=J. Immunol. |volume=163 |issue= 1 |pages= 278–87 |year= 1999 |pmid= 10384126 |display-authors=etal}}
*{{cite journal | author=Tonini R, Ferroni A, Valenzuela SM, ''et al.'' |title=Functional characterization of the NCC27 nuclear protein in stable transfected CHO-K1 cells. |journal=FASEB J. |volume=14 |issue= 9 |pages= 1171-8 |year= 2000 |pmid= 10834939 |doi= }}
*{{cite journal | vauthors=Berryman M, Bretscher A |title=Identification of a Novel Member of the Chloride Intracellular Channel Gene Family (CLIC5) That Associates with the Actin Cytoskeleton of Placental Microvilli |journal=Mol. Biol. Cell |volume=11 |issue= 5 |pages= 1509–21 |year= 2000 |pmid= 10793131 | pmc=14863 |doi=10.1091/mbc.11.5.1509}}
*{{cite journal  | author=Valenzuela SM, Mazzanti M, Tonini R, ''et al.'' |title=The nuclear chloride ion channel NCC27 is involved in regulation of the cell cycle. |journal=J. Physiol. (Lond.) |volume=529 Pt 3 |issue= |pages= 541-52 |year= 2001 |pmid= 11195932 |doi= }}
*{{cite journal  | vauthors=Tonini R, Ferroni A, Valenzuela SM |title=Functional characterization of the NCC27 nuclear protein in stable transfected CHO-K1 cells |journal=FASEB J. |volume=14 |issue= 9 |pages= 1171–8 |year= 2000 |pmid= 10834939 |display-authors=etal}}
*{{cite journal  | author=Harrop SJ, DeMaere MZ, Fairlie WD, ''et al.'' |title=Crystal structure of a soluble form of the intracellular chloride ion channel CLIC1 (NCC27) at 1.4-A resolution. |journal=J. Biol. Chem. |volume=276 |issue= 48 |pages= 44993-5000 |year= 2002 |pmid= 11551966 |doi= 10.1074/jbc.M107804200 }}
*{{cite journal  | vauthors=Valenzuela SM, Mazzanti M, Tonini R |title=The nuclear chloride ion channel NCC27 is involved in regulation of the cell cycle |journal=J. Physiol. |volume=529 Pt 3 |issue= Pt 3|pages= 541–52 |year= 2001 |pmid= 11195932 | pmc=2270212 |doi=10.1111/j.1469-7793.2000.00541.x|display-authors=etal}}
*{{cite journal  | author=Warton K, Tonini R, Fairlie WD, ''et al.'' |title=Recombinant CLIC1 (NCC27) assembles in lipid bilayers via a pH-dependent two-state process to form chloride ion channels with identical characteristics to those observed in Chinese hamster ovary cells expressing CLIC1. |journal=J. Biol. Chem. |volume=277 |issue= 29 |pages= 26003-11 |year= 2002 |pmid= 11978800 |doi= 10.1074/jbc.M203666200 }}
*{{cite journal  | vauthors=Harrop SJ, DeMaere MZ, Fairlie WD |title=Crystal structure of a soluble form of the intracellular chloride ion channel CLIC1 (NCC27) at 1.4-A resolution |journal=J. Biol. Chem. |volume=276 |issue= 48 |pages= 44993–5000 |year= 2002 |pmid= 11551966 |doi= 10.1074/jbc.M107804200 |display-authors=etal}}
*{{cite journal | author=Shanks RA, Larocca MC, Berryman M, ''et al.'' |title=AKAP350 at the Golgi apparatus. II. Association of AKAP350 with a novel chloride intracellular channel (CLIC) family member. |journal=J. Biol. Chem. |volume=277 |issue= 43 |pages= 40973-80 |year= 2002 |pmid= 12163479 |doi= 10.1074/jbc.M112277200 }}
*{{cite journal | vauthors=Warton K, Tonini R, Fairlie WD |title=Recombinant CLIC1 (NCC27) assembles in lipid bilayers via a pH-dependent two-state process to form chloride ion channels with identical characteristics to those observed in Chinese hamster ovary cells expressing CLIC1 |journal=J. Biol. Chem. |volume=277 |issue= 29 |pages= 26003–11 |year= 2002 |pmid= 11978800 |doi= 10.1074/jbc.M203666200 |display-authors=etal}}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | vauthors=Shanks RA, Larocca MC, Berryman M |title=AKAP350 at the Golgi apparatus. II. Association of AKAP350 with a novel chloride intracellular channel (CLIC) family member |journal=J. Biol. Chem. |volume=277 |issue= 43 |pages= 40973–80 |year= 2002 |pmid= 12163479 |doi= 10.1074/jbc.M112277200 |display-authors=etal}}
*{{cite journal | author=Fan L, Yu W, Zhu X |title=Interaction of Sedlin with chloride intracellular channel proteins. |journal=FEBS Lett. |volume=540 |issue= 1-3 |pages= 77-80 |year= 2003 |pmid= 12681486 |doi=  }}
*{{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal | author=Mungall AJ, Palmer SA, Sims SK, ''et al.'' |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805-11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal | vauthors=Fan L, Yu W, Zhu X |title=Interaction of Sedlin with chloride intracellular channel proteins |journal=FEBS Lett. |volume=540 |issue= 1–3 |pages= 77–80 |year= 2003 |pmid= 12681486 |doi=10.1016/S0014-5793(03)00228-X }}
*{{cite journal  | author=Littler DR, Harrop SJ, Fairlie WD, ''et al.'' |title=The intracellular chloride ion channel protein CLIC1 undergoes a redox-controlled structural transition. |journal=J. Biol. Chem. |volume=279 |issue= 10 |pages= 9298-305 |year= 2004 |pmid= 14613939 |doi= 10.1074/jbc.M308444200 }}
*{{cite journal | vauthors=Mungall AJ, Palmer SA, Sims SK |title=The DNA sequence and analysis of human chromosome 6 |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 |display-authors=etal}}
*{{cite journal | vauthors=Littler DR, Harrop SJ, Fairlie WD |title=The intracellular chloride ion channel protein CLIC1 undergoes a redox-controlled structural transition |journal=J. Biol. Chem. |volume=279 |issue= 10 |pages= 9298–305 |year= 2004 |pmid= 14613939 |doi= 10.1074/jbc.M308444200 |display-authors=etal}}
*{{cite journal | vauthors=Singh H, Cousin MA, Ashley RH |title=Functional reconstitution of mammalian 'chloride intracellular channels' CLIC1, CLIC4 and CLIC5 reveals differential regulation by cytoskeletal actin |journal=FEBS J.|volume=274 |issue= 24 |pages= 6306–6316 |year= 2007 |pmid= 18028448 |doi=10.1111/j.1742-4658.2007.06145.x }}
}}
}}
{{refend}}
{{refend}}


{{protein-stub}}
==External links==
{{WikiDoc Sources}}
* {{MeshName|CLIC1+protein,+human}}
* {{UCSC gene info|CLIC1}}
 
{{NLM content}}
{{PDB Gallery|geneid=1192}}
{{Ion channels|g4}}
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[[Category:Ion channels]]
 
 
{{membrane-protein-stub}}

Latest revision as of 09:48, 30 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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Wikidata
View/Edit Human

Chloride intracellular channel protein 1 is a protein that in humans is encoded by the CLIC1 gene.[1][2]

Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity.[2]

Interactions

CLIC1 has been shown to interact with TRAPPC2.[3]

See also

References

  1. ↑ Valenzuela SM, Martin DK, Por SB, Robbins JM, Warton K, Bootcov MR, Schofield PR, Campbell TJ, Breit SN (Jun 1997). "Molecular cloning and expression of a chloride ion channel of cell nuclei". J Biol Chem. 272 (19): 12575–82. doi:10.1074/jbc.272.19.12575. PMID 9139710.
  2. ↑ 2.0 2.1 "Entrez Gene: CLIC1 chloride intracellular channel 1".
  3. ↑ Fan, Libin; Yu Wei; Zhu Xueliang (Apr 2003). "Interaction of Sedlin with chloride intracellular channel proteins". FEBS Lett. Netherlands. 540 (1–3): 77–80. doi:10.1016/S0014-5793(03)00228-X. ISSN 0014-5793. PMID 12681486.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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