Calsenilin: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Calsenilin''' is a [[protein]] that in humans is encoded by the ''KCNIP3'' [[gene]].<ref name="pmid9771752">{{cite journal | vauthors = Buxbaum JD, Choi EK, Luo Y, Lilliehook C, Crowley AC, Merriam DE, Wasco W | title = Calsenilin: a calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragment | journal = Nat Med | volume = 4 | issue = 10 | pages = 1177–81 | date = October 1998 | pmid = 9771752 | pmc =  | doi = 10.1038/2673 }}</ref><ref name="pmid10078534">{{cite journal | vauthors = Carrión AM, Link WA, Ledo F, Mellström B, Naranjo JR | title = DREAM is a Ca2+-regulated transcriptional repressor | journal = Nature | volume = 398 | issue = 6722 | pages = 80–4 | date = March 1999 | pmid = 10078534 | pmc = | doi = 10.1038/18044 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: KCNIP3 Kv channel interacting protein 3, calsenilin| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=30818| accessdate = }}</ref>
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| update_protein_box = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Kv channel interacting protein 3, calsenilin
| HGNCid = 15523
| Symbol = KCNIP3
| AltSymbols =; CSEN; DREAM; KCHIP3; MGC18289
| OMIM = 604662
| ECnumber = 
| Homologene = 8382
| MGIid = 1929258
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003714 |text = transcription corepressor activity}} {{GNF_GO|id=GO:0005216 |text = ion channel activity}} {{GNF_GO|id=GO:0005244 |text = voltage-gated ion channel activity}} {{GNF_GO|id=GO:0005267 |text = potassium channel activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0030955 |text = potassium ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006357 |text = regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006813 |text = potassium ion transport}} {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0007165 |text = signal transduction}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 30818
    | Hs_Ensembl = ENSG00000115041
    | Hs_RefseqProtein = NP_001030086
    | Hs_RefseqmRNA = NM_001034914
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 95326799
    | Hs_GenLoc_end = 95415551
    | Hs_Uniprot = Q9Y2W7
    | Mm_EntrezGene = 56461
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = NM_019789
    | Mm_RefseqProtein = NP_062763
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Kv channel interacting protein 3, calsenilin''', also known as '''KCNIP3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: KCNIP3 Kv channel interacting protein 3, calsenilin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=30818| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the neuronal calcium sensor family of proteins.<ref name="pmid17311005">{{cite journal | vauthors = Burgoyne RD | title = Neuronal Calcium Sensor Proteins: Generating Diversity in Neuronal Ca2+ Signalling | journal = Nat. Rev. Neurosci. | volume = 8 | issue = 3 | pages = 182–193 | year = 2007 | pmid = 17311005 | pmc = 1887812 | doi = 10.1038/nrn2093 }}</ref><ref name="pmid15046879">{{cite journal | vauthors = Burgoyne RD, O'Callaghan DW, Hasdemir B, Haynes LP, Tepikin AV | title = Neuronal Ca2+-sensor proteins: multitalented regulators of neuronal function | journal = Trends Neurosci. | volume = 27 | issue = 4 | pages = 203–9 | year = 2004 | pmid = 15046879 | doi = 10.1016/j.tins.2004.01.010 }}</ref> Members of this family are small calcium binding proteins containing [[EF-hand]]-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with [[presenilin]]s. In addition, the protein has been shown to transcriptionally repress A20 ([[TNFAIP3]]) expression and thus modulate the anti-inflammatory signaling.<ref name="PMC4005385">{{cite journal | vauthors = Tiruppathi C,Soni D, Wang DM, et al. | title = The transcription factor DREAM represses A20 and mediates inflammation | journal = Nat Immunol | volume = 15 | issue = 3 | pages = 239–247 | date = March 2014 | pmid = 4005385 | pmc = 4005385 | doi = 10.1038/ni.2823 }}</ref> [[Alternatively spliced]] transcript variants encoding different isoforms have been described.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Alternatively spliced transcript variants encoding different isoforms have been described.<ref name="entrez">{{cite web | title = Entrez Gene: KCNIP3 Kv channel interacting protein 3, calsenilin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=30818| accessdate = }}</ref>
}}


==See also==
== Interactions ==
 
Calsenilin has been shown to [[Protein-protein interaction|interact]] with [[PSEN1]]<ref name=pmid9771752 /><ref name=pmid10854253>{{cite journal | vauthors = Kashiwa A, Yoshida H, Lee S, Paladino T, Liu Y, Chen Q, Dargusch R, Schubert D, Kimura H | title = Isolation and characterization of novel presenilin binding protein | journal = J. Neurochem. | volume = 75 | issue = 1 | pages = 109–16 | date = July 2000 | pmid = 10854253 | doi = 10.1046/j.1471-4159.2000.0750109.x }}</ref> and [[PSEN2]].<ref name=pmid9771752/><ref name=pmid11278424>{{cite journal | vauthors = Choi EK, Zaidi NF, Miller JS, Crowley AC, Merriam DE, Lilliehook C, Buxbaum JD, Wasco W | title = Calsenilin is a substrate for caspase-3 that preferentially interacts with the familial Alzheimer's disease-associated C-terminal fragment of presenilin 2 | journal = J. Biol. Chem. | volume = 276 | issue = 22 | pages = 19197–204 | date = June 2001 | pmid = 11278424 | doi = 10.1074/jbc.M008597200 }}</ref>
 
== See also ==
* [[Voltage-gated potassium channel]]
* [[Voltage-gated potassium channel]]
{{Clear}}


==References==
== References ==
{{reflist|2}}
{{reflist|35em}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin|35em}}
{{PBB_Further_reading
* {{cite journal | vauthors = Carrión AM, Mellström B, Naranjo JR | title = Protein Kinase A-Dependent Derepression of the Human Prodynorphin Gene via Differential Binding to an Intragenic Silencer Element | journal = Mol. Cell. Biol. | volume = 18 | issue = 12 | pages = 6921–9 | year = 1998 | pmid = 9819380 | pmc = 109275 | doi = }}
| citations =
* {{cite journal | vauthors = An WF, Bowlby MR, Betty M, Cao J, Ling HP, Mendoza G, Hinson JW, Mattsson KI, Strassle BW, Trimmer JS, Rhodes KJ | title = Modulation of A-type potassium channels by a family of calcium sensors | journal = Nature | volume = 403 | issue = 6769 | pages = 553–6 | year = 2000 | pmid = 10676964 | doi = 10.1038/35000592 }}
*{{cite journal | author=Buxbaum JD, Choi EK, Luo Y, ''et al.'' |title=Calsenilin: a calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragment. |journal=Nat. Med. |volume=4 |issue= 10 |pages= 1177-81 |year= 1998 |pmid= 9771752 |doi= 10.1038/2673 }}
* {{cite journal | vauthors = Leissring MA, Yamasaki TR, Wasco W, Buxbaum JD, Parker I, LaFerla FM | title = Calsenilin reverses presenilin-mediated enhancement of calcium signaling | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 97 | issue = 15 | pages = 8590–3 | year = 2000 | pmid = 10900016 | pmc = 26992 | doi = 10.1073/pnas.97.15.8590 }}
*{{cite journal | author=Carrión AM, Mellström B, Naranjo JR |title=Protein kinase A-dependent derepression of the human prodynorphin gene via differential binding to an intragenic silencer element. |journal=Mol. Cell. Biol. |volume=18 |issue= 12 |pages= 6921-9 |year= 1998 |pmid= 9819380 |doi= }}
* {{cite journal | vauthors = Buxbaum JD, Lilliehook C, Chan JY, Go RC, Bassett SS, Tanzi RE, Wasco W, Blacker D | title = Genomic structure, expression pattern, and chromosomal localization of the human calsenilin gene: no association between an exonic polymorphism and Alzheimer's disease | journal = Neurosci. Lett. | volume = 294 | issue = 3 | pages = 135–8 | year = 2000 | pmid = 11072133 | doi = 10.1016/S0304-3940(00)01553-6 }}
*{{cite journal | author=Carrión AM, Link WA, Ledo F, ''et al.'' |title=DREAM is a Ca2+-regulated transcriptional repressor. |journal=Nature |volume=398 |issue= 6722 |pages= 80-4 |year= 1999 |pmid= 10078534 |doi= 10.1038/18044 }}
* {{cite journal | vauthors = Ledo F, Carrión AM, Link WA, Mellström B, Naranjo JR | title = DREAM-αCREM Interaction via Leucine-Charged Domains Derepresses Downstream Regulatory Element-Dependent Transcription | journal = Mol. Cell. Biol. | volume = 20 | issue = 24 | pages = 9120–6 | year = 2001 | pmid = 11094064 | pmc = 102170 | doi = 10.1128/MCB.20.24.9120-9126.2000 }}
*{{cite journal | author=An WF, Bowlby MR, Betty M, ''et al.'' |title=Modulation of A-type potassium channels by a family of calcium sensors. |journal=Nature |volume=403 |issue= 6769 |pages= 553-6 |year= 2000 |pmid= 10676964 |doi= 10.1038/35000592 }}
* {{cite journal | vauthors = Jo DG, Kim MJ, Choi YH, Kim IK, Song YH, Woo HN, Chung CW, Jung YK | title = Pro-apoptotic function of calsenilin/DREAM/KChIP3 | journal = FASEB J. | volume = 15 | issue = 3 | pages = 589–91 | year = 2001 | pmid = 11259376 | doi = 10.1096/fj.00-0541fje }}
*{{cite journal | author=Leissring MA, Yamasaki TR, Wasco W, ''et al.'' |title=Calsenilin reverses presenilin-mediated enhancement of calcium signaling. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 15 |pages= 8590-3 |year= 2000 |pmid= 10900016 |doi= }}
* {{cite journal | vauthors = Choi EK, Zaidi NF, Miller JS, Crowley AC, Merriam DE, Lilliehook C, Buxbaum JD, Wasco W | title = Calsenilin is a substrate for caspase-3 that preferentially interacts with the familial Alzheimer's disease-associated C-terminal fragment of presenilin 2 | journal = J. Biol. Chem. | volume = 276 | issue = 22 | pages = 19197–204 | year = 2001 | pmid = 11278424 | doi = 10.1074/jbc.M008597200 }}
*{{cite journal | author=Buxbaum JD, Lilliehook C, Chan JY, ''et al.'' |title=Genomic structure, expression pattern, and chromosomal localization of the human calsenilin gene: no association between an exonic polymorphism and Alzheimer's disease. |journal=Neurosci. Lett. |volume=294 |issue= 3 |pages= 135-8 |year= 2000 |pmid= 11072133 |doi= }}
* {{cite journal | vauthors = Osawa M, Tong KI, Lilliehook C, Wasco W, Buxbaum JD, Cheng HY, Penninger JM, Ikura M, Ames JB | title = Calcium-regulated DNA binding and oligomerization of the neuronal calcium-sensing protein, calsenilin/DREAM/KChIP3 | journal = J. Biol. Chem. | volume = 276 | issue = 44 | pages = 41005–13 | year = 2001 | pmid = 11535596 | doi = 10.1074/jbc.M105842200 }}
*{{cite journal | author=Ledo F, Carrión AM, Link WA, ''et al.'' |title=DREAM-alphaCREM interaction via leucine-charged domains derepresses downstream regulatory element-dependent transcription. |journal=Mol. Cell. Biol. |volume=20 |issue= 24 |pages= 9120-6 |year= 2001 |pmid= 11094064 |doi= }}
* {{cite journal | vauthors = Cheng HY, Pitcher GM, Laviolette SR, Whishaw IQ, Tong KI, Kockeritz LK, Wada T, Joza NA, Crackower M, Goncalves J, Sarosi I, Woodgett JR, Oliveira-dos-Santos AJ, Ikura M, van der Kooy D, Salter MW, Penninger JM | title = DREAM is a critical transcriptional repressor for pain modulation | journal = Cell | volume = 108 | issue = 1 | pages = 31–43 | year = 2002 | pmid = 11792319 | doi = 10.1016/S0092-8674(01)00629-8 }}
*{{cite journal | author=Jo DG, Kim MJ, Choi YH, ''et al.'' |title=Pro-apoptotic function of calsenilin/DREAM/KChIP3. |journal=FASEB J. |volume=15 |issue= 3 |pages= 589-91 |year= 2001 |pmid= 11259376 |doi= 10.1096/fj.00-0541fje }}
* {{cite journal | vauthors = Lilliehook C, Chan S, Choi EK, Zaidi NF, Wasco W, Mattson MP, Buxbaum JD | title = Calsenilin enhances apoptosis by altering endoplasmic reticulum calcium signaling | journal = Mol. Cell. Neurosci. | volume = 19 | issue = 4 | pages = 552–9 | year = 2002 | pmid = 11988022 | doi = 10.1006/mcne.2001.1096 }}
*{{cite journal | author=Choi EK, Zaidi NF, Miller JS, ''et al.'' |title=Calsenilin is a substrate for caspase-3 that preferentially interacts with the familial Alzheimer's disease-associated C-terminal fragment of presenilin 2. |journal=J. Biol. Chem. |volume=276 |issue= 22 |pages= 19197-204 |year= 2001 |pmid= 11278424 |doi= 10.1074/jbc.M008597200 }}
* {{cite journal | vauthors = Takimoto K, Yang EK, Conforti L | title = Palmitoylation of KChIP splicing variants is required for efficient cell surface expression of Kv4.3 channels | journal = J. Biol. Chem. | volume = 277 | issue = 30 | pages = 26904–11 | year = 2002 | pmid = 12006572 | doi = 10.1074/jbc.M203651200 }}
*{{cite journal | author=Osawa M, Tong KI, Lilliehook C, ''et al.'' |title=Calcium-regulated DNA binding and oligomerization of the neuronal calcium-sensing protein, calsenilin/DREAM/KChIP3. |journal=J. Biol. Chem. |volume=276 |issue= 44 |pages= 41005-13 |year= 2001 |pmid= 11535596 |doi= 10.1074/jbc.M105842200 }}
* {{cite journal | vauthors = Ledo F, Kremer L, Mellström B, Naranjo JR | title = Ca2+-dependent block of CREB–CBP transcription by repressor DREAM | journal = EMBO J. | volume = 21 | issue = 17 | pages = 4583–92 | year = 2002 | pmid = 12198160 | pmc = 126180 | doi = 10.1093/emboj/cdf440 }}
*{{cite journal | author=Cheng HY, Pitcher GM, Laviolette SR, ''et al.'' |title=DREAM is a critical transcriptional repressor for pain modulation. |journal=Cell |volume=108 |issue= 1 |pages= 31-43 |year= 2002 |pmid= 11792319 |doi= }}
* {{cite journal | vauthors = Zaidi NF, Berezovska O, Choi EK, Miller JS, Chan H, Lilliehook C, Hyman BT, Buxbaum JD, Wasco W | title = Biochemical and immunocytochemical characterization of calsenilin in mouse brain | journal = Neuroscience | volume = 114 | issue = 1 | pages = 247–63 | year = 2002 | pmid = 12207970 | doi = 10.1016/S0306-4522(02)00251-8 }}
*{{cite journal | author=Lilliehook C, Chan S, Choi EK, ''et al.'' |title=Calsenilin enhances apoptosis by altering endoplasmic reticulum calcium signaling. |journal=Mol. Cell. Neurosci. |volume=19 |issue= 4 |pages= 552-9 |year= 2002 |pmid= 11988022 |doi= 10.1006/mcne.2001.1096 }}
* {{cite journal | vauthors = Sanz C, Horita M, Fernandez-Luna JL | title = Fas signaling and blockade of Bcr-Abl kinase induce apoptotic Hrk protein via DREAM inhibition in human leukemia cells | journal = Haematologica | volume = 87 | issue = 9 | pages = 903–7 | year = 2004 | pmid = 12217801 | doi =  }}
*{{cite journal | author=Takimoto K, Yang EK, Conforti L |title=Palmitoylation of KChIP splicing variants is required for efficient cell surface expression of Kv4.3 channels. |journal=J. Biol. Chem. |volume=277 |issue= 30 |pages= 26904-11 |year= 2002 |pmid= 12006572 |doi= 10.1074/jbc.M203651200 }}
* {{cite journal | vauthors = Schrader LA, Anderson AE, Mayne A, Pfaffinger PJ, Sweatt JD | title = PKA modulation of Kv4.2-encoded A-type potassium channels requires formation of a supramolecular complex | journal = J. Neurosci. | volume = 22 | issue = 23 | pages = 10123–33 | year = 2002 | pmid = 12451113 | doi =  }}
*{{cite journal | author=Ledo F, Kremer L, Mellström B, Naranjo JR |title=Ca2+-dependent block of CREB-CBP transcription by repressor DREAM. |journal=EMBO J. |volume=21 |issue= 17 |pages= 4583-92 |year= 2002 |pmid= 12198160 |doi=  }}
* {{cite journal | vauthors = Hong YM, Jo DG, Lee MC, Kim SY, Jung YK | title = Reduced expression of calsenilin/DREAM/KChIP3 in the brains of kainic acid-induced seizure and epilepsy patients | journal = Neurosci. Lett. | volume = 340 | issue = 1 | pages = 33–6 | year = 2003 | pmid = 12648752 | doi = 10.1016/S0304-3940(03)00067-3 }}
*{{cite journal | author=Zaidi NF, Berezovska O, Choi EK, ''et al.'' |title=Biochemical and immunocytochemical characterization of calsenilin in mouse brain. |journal=Neuroscience |volume=114 |issue= 1 |pages= 247-63 |year= 2002 |pmid= 12207970 |doi=  }}
* {{cite journal | vauthors = Shibata R, Misonou H, Campomanes CR, Anderson AE, Schrader LA, Doliveira LC, Carroll KI, Sweatt JD, Rhodes KJ, Trimmer JS | title = A fundamental role for KChIPs in determining the molecular properties and trafficking of Kv4.2 potassium channels | journal = J. Biol. Chem. | volume = 278 | issue = 38 | pages = 36445–54 | year = 2003 | pmid = 12829703 | doi = 10.1074/jbc.M306142200 }}
*{{cite journal | author=Sanz C, Horita M, Fernandez-Luna JL |title=Fas signaling and blockade of Bcr-Abl kinase induce apoptotic Hrk protein via DREAM inhibition in human leukemia cells. |journal=Haematologica |volume=87 |issue= 9 |pages= 903-7 |year= 2004 |pmid= 12217801 |doi= }}
* {{cite journal | vauthors = Venn N, Haynes LP, Burgoyne RD | title = Specific effects of KChIP3/calsenilin/DREAM, but not KChIPs 1, 2 and 4, on calcium signalling and regulated secretion in PC12 cells | journal = Biochem. J. | volume = 413 | issue = 1 | pages = 71–80 | year = 2008 | pmid = 18393943 | pmc = 2474559 | doi = 10.1042/BJ20080441 }}
*{{cite journal | author=Schrader LA, Anderson AE, Mayne A, ''et al.'' |title=PKA modulation of Kv4.2-encoded A-type potassium channels requires formation of a supramolecular complex. |journal=J. Neurosci. |volume=22 |issue= 23 |pages= 10123-33 |year= 2002 |pmid= 12451113 |doi= }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Hong YM, Jo DG, Lee MC, ''et al.'' |title=Reduced expression of calsenilin/DREAM/KChIP3 in the brains of kainic acid-induced seizure and epilepsy patients. |journal=Neurosci. Lett. |volume=340 |issue= 1 |pages= 33-6 |year= 2003 |pmid= 12648752 |doi=  }}
*{{cite journal  | author=Shibata R, Misonou H, Campomanes CR, ''et al.'' |title=A fundamental role for KChIPs in determining the molecular properties and trafficking of Kv4.2 potassium channels. |journal=J. Biol. Chem. |volume=278 |issue= 38 |pages= 36445-54 |year= 2003 |pmid= 12829703 |doi= 10.1074/jbc.M306142200 }}
}}
{{refend}}
{{refend}}


== External links ==
== External links ==
* {{MeshName|KCNIP3+protein,+human}}
* {{MeshName|KCNIP3+protein,+human}}
*[http://www.liv.ac.uk/physiology/ncs/index.html NCS proteins]
{{NLM content}}
{{Ion channels|g3}}
[[Category:EF-hand-containing proteins]]


{{membrane-protein-stub}}
{{membrane-protein-stub}}
{{NLM content}}
{{Ion channels}}

Latest revision as of 10:33, 30 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Calsenilin is a protein that in humans is encoded by the KCNIP3 gene.[1][2][3]

Function

This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the neuronal calcium sensor family of proteins.[4][5] Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. In addition, the protein has been shown to transcriptionally repress A20 (TNFAIP3) expression and thus modulate the anti-inflammatory signaling.[6] Alternatively spliced transcript variants encoding different isoforms have been described.[3]

Interactions

Calsenilin has been shown to interact with PSEN1[1][7] and PSEN2.[1][8]

See also

References

  1. ↑ 1.0 1.1 1.2 Buxbaum JD, Choi EK, Luo Y, Lilliehook C, Crowley AC, Merriam DE, Wasco W (October 1998). "Calsenilin: a calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragment". Nat Med. 4 (10): 1177–81. doi:10.1038/2673. PMID 9771752.
  2. ↑ Carrión AM, Link WA, Ledo F, Mellström B, Naranjo JR (March 1999). "DREAM is a Ca2+-regulated transcriptional repressor". Nature. 398 (6722): 80–4. doi:10.1038/18044. PMID 10078534.
  3. ↑ 3.0 3.1 "Entrez Gene: KCNIP3 Kv channel interacting protein 3, calsenilin".
  4. ↑ Burgoyne RD (2007). "Neuronal Calcium Sensor Proteins: Generating Diversity in Neuronal Ca2+ Signalling". Nat. Rev. Neurosci. 8 (3): 182–193. doi:10.1038/nrn2093. PMC 1887812. PMID 17311005.
  5. ↑ Burgoyne RD, O'Callaghan DW, Hasdemir B, Haynes LP, Tepikin AV (2004). "Neuronal Ca2+-sensor proteins: multitalented regulators of neuronal function". Trends Neurosci. 27 (4): 203–9. doi:10.1016/j.tins.2004.01.010. PMID 15046879.
  6. ↑ Tiruppathi C, Soni D, Wang DM, et al. (March 2014). "The transcription factor DREAM represses A20 and mediates inflammation". Nat Immunol. 15 (3): 239–247. doi:10.1038/ni.2823. PMC 4005385. PMID 4005385.
  7. ↑ Kashiwa A, Yoshida H, Lee S, Paladino T, Liu Y, Chen Q, Dargusch R, Schubert D, Kimura H (July 2000). "Isolation and characterization of novel presenilin binding protein". J. Neurochem. 75 (1): 109–16. doi:10.1046/j.1471-4159.2000.0750109.x. PMID 10854253.
  8. ↑ Choi EK, Zaidi NF, Miller JS, Crowley AC, Merriam DE, Lilliehook C, Buxbaum JD, Wasco W (June 2001). "Calsenilin is a substrate for caspase-3 that preferentially interacts with the familial Alzheimer's disease-associated C-terminal fragment of presenilin 2". J. Biol. Chem. 276 (22): 19197–204. doi:10.1074/jbc.M008597200. PMID 11278424.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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