High chylomicron remnant causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mugilan Poongkunran M.B.B.S [2]


High chylomicron remnants level can either be due to genetic conditions as in type I and type V hyperlipoproteinemia or can be secondary to conditions such as chronic renal failure, hypothyroidism, and diabetes mellitus.


Life Threatening Causes

Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated.

Common Causes

Causes by Organ System

Cardiovascular No underlying causes
Chemical/Poisoning No underlying causes
Dental No underlying causes
Dermatologic No underlying causes
Drug Side Effect Antiretroviral therapy, atypical antipsychotics, glucocorticoids, heparin, isotretinoin, oral contraceptives, tamoxifen, thiazide diuretics
Ear Nose Throat No underlying causes
Endocrine Diabetes mellitus, hypothyroidism
Environmental No underlying causes
Gastroenterologic Acute pancreatitis, alcoholic liver disease, cirrhosis, hepatitis, hereditary hemochromatosis, non-alcoholic steatohepatitis (NASH), Wilson's disease
Genetic Familial hypertriglyceridemia, fructose-1-phosphate aldolase deficiency, galactosemia, glycogen storage disease type I, glycogen storage disease type IV, lipoprotein lipase deficiency, mixed hyperlipoproteinemia, type 1C hyperlipoproteinemia, tyrosinemia type 1
Hematologic No underlying causes
Iatrogenic Dialysis
Infectious Disease No underlying causes
Musculoskeletal/Orthopedic No underlying causes
Neurologic No underlying causes
Nutritional/Metabolic Familial hypertriglyceridemia, glycogen storage disease type I, glycogen storage disease type IV, high carbohydrate diet, high saturated fat diet, isolated low HDL, lipoprotein lipase deficiency
Obstetric/Gynecologic Pregnancy
Oncologic No underlying causes
Ophthalmologic No underlying causes
Overdose/Toxicity No underlying causes
Psychiatric No underlying causes
Pulmonary No underlying causes
Renal/Electrolyte Acute renal failure, chronic renal failure, nephrotic syndrome
Rheumatology/Immunology/Allergy Autoimmune hyperchylomicronemia [1]
Sexual No underlying causes
Trauma No underlying causes
Urologic No underlying causes
Miscellaneous Alcoholism

Causes by Alphabetical Order


  1. 1.0 1.1 Yoshimura, T.; Ito, M.; Sakoda, Y.; Kobori, S.; Okamura, H. (1998). "Rare case of autoimmune hyperchylomicronemia during pregnancy". Eur J Obstet Gynecol Reprod Biol. 76 (1): 49–51. PMID 9481547. Unknown parameter |month= ignored (help)
  2. Weintraub M, Burstein A, Rassin T, Liron M, Ringel Y, Cabili S; et al. (1992). "Severe defect in clearing postprandial chylomicron remnants in dialysis patients". Kidney Int. 42 (5): 1247–52. PMID 1453610.
  3. Ito M, Takamatsu J, Matsuo T, Kameoka K, Kubota S, Fukata S; et al. (2003). "Serum concentrations of remnant-like particles in hypothyroid patients before and after thyroxine replacement". Clin Endocrinol (Oxf). 58 (5): 621–6. PMID 12699445.
  4. Benjó AM, Maranhão RC, Coimbra SR, Andrade AC, Favarato D, Molina MS; et al. (2006). "Accumulation of chylomicron remnants and impaired vascular reactivity occur in subjects with isolated low HDL cholesterol: effects of niacin treatment". Atherosclerosis. 187 (1): 116–22. doi:10.1016/j.atherosclerosis.2005.08.025. PMID 16458316.
  5. Brasaemle DL, Cornely-Moss K, Bensadoun A (1993). "Hepatic lipase treatment of chylomicron remnants increases exposure of apolipoprotein E." J Lipid Res. 34 (3): 455–65. PMID 8468529.