Acoustic neuroma pathophysiology

Jump to: navigation, search

Acoustic neuroma Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Acoustic neuroma from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

X-ray

Echocardiography or Ultrasound

CT

MRI

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Acoustic neuroma pathophysiology On the Web

Most recent articles

cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Acoustic neuroma pathophysiology

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Acoustic neuroma pathophysiology

CDC on Acoustic neuroma pathophysiology

Acoustic neuroma pathophysiology in the news

Blogs on Acoustic neuroma pathophysiology

Directions to Hospitals Treating Acoustic neuroma

Risk calculators and risk factors for Acoustic neuroma pathophysiology

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2] Mohsen Basiri M.D. Sabawoon Mirwais, M.B.B.S.[3]

Overview

Acoustic neuroma arises from Schwann cells, which are the cells involved in the conduction of nervous impulses along axons, nerve development and regeneration. On microscopic histopathological analysis, acoustic neuroma may display two types of growth patterns: Antoni type A and Antoni type B. Antoni type A growth pattern is composed of elongated cells with cytoplasmic processes arranged in fascicles, little stromal matrix and verocay bodies. Antoni type B growth pattern is composed of loose meshwork of cells, less dense cellular matrix, microcysts and myxoid change.

Pathophysiology

Genetic

Associated Conditions

Gross Pathology

On gross pathology, following are the characteristic findings of acoustic neuroma:

  • Rubbery-firm with a pale, gray color[3]
  • Well-defined capsule
  • Different degrees of vascularity

On Cut Section

Microscopic Pathology

On Light Microscopy

1. Antoni A

  • Antoni A tissue is small with organized and interwoven course of elongated bipolar cells.[6]
  • The spiral framework, formed by the arrangement of the nuclei and fibers, can resemble a meningioma.
  • Verocay bodies can also be seen.[7]

2. Antoni B

On Electron Microscopy

The following findings on electron microscopy are characteristic of an acoustic neuroma:

References

  1. Acoustic Schwannoma. Radiopedia(2015) http://radiopaedia.org/articles/acoustic-schwannoma Accessed on October 2 2015
  2. M. M. Eibl, R. Ahmad, H. M. Wolf, Y. Linnau, E. Gotz & J. W. Mannhalter (1987). "A component of factor VIII preparations which can be separated from factor VIII activity down modulates human monocyte functions". Blood. 69 (4): 1153–1160. PMID 3030465. Unknown parameter |month= ignored (help)
  3. Joshua Greene & Mohammed A.. Al-Dhahir (2019). "Acoustic Neuroma (Vestibular Schwannoma)". PMID 29262098. Unknown parameter |month= ignored (help)
  4. Joshua Greene & Mohammed A.. Al-Dhahir (2019). "Acoustic Neuroma (Vestibular Schwannoma)". PMID 29262098. Unknown parameter |month= ignored (help)
  5. Joshua Greene & Mohammed A.. Al-Dhahir (2019). "Acoustic Neuroma (Vestibular Schwannoma)". PMID 29262098. Unknown parameter |month= ignored (help)
  6. Joshua Greene & Mohammed A.. Al-Dhahir (2019). "Acoustic Neuroma (Vestibular Schwannoma)". PMID 29262098. Unknown parameter |month= ignored (help)
  7. Wippold, F.J.; Lubner, M.; Perrin, R.J.; Lammle, M.; Perry, A. (2007). "Neuropathology for the Neuroradiologist: Antoni A and Antoni B Tissue Patterns". American Journal of Neuroradiology. 28 (9): 1633–1638. doi:10.3174/ajnr.A0682. ISSN 0195-6108.
  8. Joshua Greene & Mohammed A.. Al-Dhahir (2019). "Acoustic Neuroma (Vestibular Schwannoma)". PMID 29262098. Unknown parameter |month= ignored (help)
  9. Joshua Greene & Mohammed A.. Al-Dhahir (2019). "Acoustic Neuroma (Vestibular Schwannoma)". PMID 29262098. Unknown parameter |month= ignored (help)
  10. Lukas D. Landegger, Jessica E. Sagers, Sonam Dilwali, Takeshi Fujita, Mehmet I. Sahin & Konstantina M. Stankovic (2017). "A Unified Methodological Framework for Vestibular Schwannoma Research". Journal of visualized experiments : JoVE (124). doi:10.3791/55827. PMID 28654042. Unknown parameter |month= ignored (help)

Linked-in.jpg