Pheochromocytoma natural history, complications and prognosis: Difference between revisions

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==Natural History, Complication and Prognosis==
==Natural History, Complication and Prognosis==
===Natural History===
===Natural History===
Pheochromocytoma is adrenaline secreting tumor, usually develop in fifth decade of life. Symptoms start with tachycardia, hypertension, headache and sweating. If left untreated it causes hyperglycemia, [[Hypertensive Emergencies|hypertension emergency]] that causes heart failure, [[Stroke|cerebrovascular strokes]]. If malignant, It cam metastasize to [[lymph nodes]], [[bones]], [[lungs]], and [[liver]].
* Pheochromocytoma is adrenaline secreting tumor, usually develop in fifth decade of life.  
 
*Fifty percent of pheochromocytomas in children are solitary intra-adrenal lesions, 25% are present bilaterally, and 25% are extra-adrenal.
*Most catecholamine-secreting tumors are sporadic.
*However, 30% of patients got the tumor as a part of familial disease, the catecholamine-secreting tumors are more likely to be bilateral.<ref name="pmid28324046">{{cite journal| author=Pamporaki C, Hamplova B, Peitzsch M, Prejbisz A, Beuschlein F, Timmers HJLM et al.| title=Characteristics of Pediatric vs Adult Pheochromocytomas and Paragangliomas. | journal=J Clin Endocrinol Metab | year= 2017 | volume= 102 | issue= 4 | pages= 1122-1132 | pmid=28324046 | doi=10.1210/jc.2016-3829 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28324046  }}</ref>
Symptoms start with tachycardia, hypertension, headache and sweating. If left untreated it causes hyperglycemia, [[Hypertensive Emergencies|hypertension emergency]] that causes heart failure, [[Stroke|cerebrovascular strokes]]. If malignant, It cam metastasize to [[lymph nodes]], [[bones]], [[lungs]], and [[liver]].


===Complication===
===Complication===

Revision as of 15:19, 10 July 2017

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Overview

Pheochromocytoma is adrenaline secreting tumor, usually develop in fifth decade of life. Symptoms start with tachycardia, hypertension, headache and sweating. Massive release of catecholamines can causes hyperglycemia, malignant hypertension and metastasis. The prognosis of pheochromocytoma is generally good but metastatic pheochromocytoma has a 5-year survival rate of approximately 50%[1]

Natural History, Complication and Prognosis

Natural History

  • Pheochromocytoma is adrenaline secreting tumor, usually develop in fifth decade of life.
  • Fifty percent of pheochromocytomas in children are solitary intra-adrenal lesions, 25% are present bilaterally, and 25% are extra-adrenal.
  • Most catecholamine-secreting tumors are sporadic.
  • However, 30% of patients got the tumor as a part of familial disease, the catecholamine-secreting tumors are more likely to be bilateral.[2]

Symptoms start with tachycardia, hypertension, headache and sweating. If left untreated it causes hyperglycemia, hypertension emergency that causes heart failure, cerebrovascular strokes. If malignant, It cam metastasize to lymph nodes, bones, lungs, and liver.

Complication

Other complications may include:

Prognosis

  • Pheochromocytoma prognosis is good if treated.
  • Approximately 10% recur after being resected.
  • Patients with metastatic pheochromocytoma five-year survival rates are approximately 50%.[1]. Survival rate may depend on the primary tumor site and sites of metastases.
  • Tumor burden, location of metastases, and rate of progression are the main factors affecting prognosis. Metastases in brain, liver have a worse prognosis than other metastases.

References

  1. 1.0 1.1 National Cancer Institute. Physician Data Query Database 2015. http://www.cancer.gov/types/pheochromocytoma/hp/pheochromocytoma-treatment-pdq#link/_25_toc
  2. Pamporaki C, Hamplova B, Peitzsch M, Prejbisz A, Beuschlein F, Timmers HJLM; et al. (2017). "Characteristics of Pediatric vs Adult Pheochromocytomas and Paragangliomas". J Clin Endocrinol Metab. 102 (4): 1122–1132. doi:10.1210/jc.2016-3829. PMID 28324046.
  3. 3.0 3.1 Goldman 2011, pp. 327


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