Pheochromocytoma history and symptoms: Difference between revisions

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== Symptoms ==
== Symptoms ==


===Common Symptoms===
===Common symptoms===
Common symptoms of pheochromocytoma are secondary to [[sympathetic nervous system]] hyperactivity. [[Symptoms]] usually subside in less than one hour and they may include:
Common symptoms of pheochromocytoma are secondary to [[sympathetic nervous system]] hyperactivity. [[Symptoms]] usually subside in less than one hour and they may include:


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*It may be [[asymptomatic]] and discovered incidentally after [[Screening (medicine)|screening]] for [[MEN, type 2|MEN]] patients.
*It may be [[asymptomatic]] and discovered incidentally after [[Screening (medicine)|screening]] for [[MEN, type 2|MEN]] patients.


=== Less Common Symptoms ===
=== Less common symptoms ===
Less common symptoms include:  
Less common symptoms include:  
* [[Cardiomyopathy]]: rare symptom due to [[catecholamine]] excess mimics [[takotsubo cardiomyopathy]].<ref name="pmid19158054">{{cite journal| author=Kassim TA, Clarke DD, Mai VQ, Clyde PW, Mohamed Shakir KM| title=Catecholamine-induced cardiomyopathy. | journal=Endocr Pract | year= 2008 | volume= 14 | issue= 9 | pages= 1137-49 | pmid=19158054 | doi=10.4158/EP.14.9.1137 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19158054  }}</ref> Patient improves after medical treatment or surgical removal of the tumor.
* [[Cardiomyopathy]]: rare symptom due to [[catecholamine]] excess mimics [[takotsubo cardiomyopathy]].<ref name="pmid19158054">{{cite journal| author=Kassim TA, Clarke DD, Mai VQ, Clyde PW, Mohamed Shakir KM| title=Catecholamine-induced cardiomyopathy. | journal=Endocr Pract | year= 2008 | volume= 14 | issue= 9 | pages= 1137-49 | pmid=19158054 | doi=10.4158/EP.14.9.1137 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19158054  }}</ref> Patient improves after medical treatment or surgical removal of the tumor.
* [[Epinephrine]] secreting masses can cause episodic [[hypotension]].<ref name="pmid8076587">{{cite journal| author=Bravo EL| title=Evolving concepts in the pathophysiology, diagnosis, and treatment of pheochromocytoma. | journal=Endocr Rev | year= 1994 | volume= 15 | issue= 3 | pages= 356-68 | pmid=8076587 | doi=10.1210/edrv-15-3-356 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8076587  }}</ref>
* [[Epinephrine]] secreting masses can cause episodic [[hypotension]].<ref name="pmid8076587">{{cite journal| author=Bravo EL| title=Evolving concepts in the pathophysiology, diagnosis, and treatment of pheochromocytoma. | journal=Endocr Rev | year= 1994 | volume= 15 | issue= 3 | pages= 356-68 | pmid=8076587 | doi=10.1210/edrv-15-3-356 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8076587  }}</ref>


=== Symptoms of Associated diseases ===
=== Symptoms of associated diseases ===
Pheochromocytoma patients may show symptoms of other diseases in MEN2 syndromes such as:
Pheochromocytoma patients may show symptoms of other diseases in MEN2 syndromes such as:
* [[Hyperparathyroidism]]
* [[Hyperparathyroidism]]

Revision as of 19:08, 30 August 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Ahmad Al Maradni, M.D. [2]Mohammed Abdelwahed M.D[3]

Overview

Common symptoms of pheochromocytoma include episodes of palpitations, sweating and headaches.[1] Most patients are asymptomatic. Less common symptoms include cardiomypathy and episodic hypotension.[2] Patients may have a history of recurrent attacks of palpitation or family history of pheochromocytoma. Patients may show symptoms of other multiple endocrine neoplasias associated diseases such as that of medullary thyroid cancer and hyperparathyroidism.

History

Past medical history

  • Patients suffering from pheochromocytoma may have a positive past medical history of recurrent attacks of palpitation or panic attacks.

Family history

Symptoms

Common symptoms

Common symptoms of pheochromocytoma are secondary to sympathetic nervous system hyperactivity. Symptoms usually subside in less than one hour and they may include:

Less common symptoms

Less common symptoms include:

Symptoms of associated diseases

Pheochromocytoma patients may show symptoms of other diseases in MEN2 syndromes such as:

References

  1. Stein PP, Black HR (1991). "A simplified diagnostic approach to pheochromocytoma. A review of the literature and report of one institution's experience". Medicine (Baltimore). 70 (1): 46–66. PMID 1988766.
  2. Baguet JP, Hammer L, Mazzuco TL, Chabre O, Mallion JM, Sturm N; et al. (2004). "Circumstances of discovery of phaeochromocytoma: a retrospective study of 41 consecutive patients". Eur J Endocrinol. 150 (5): 681–6. PMID 15132724.
  3. Bravo EL, Gifford RW (1993). "Pheochromocytoma". Endocrinol Metab Clin North Am. 22 (2): 329–41. PMID 8325290.
  4. Kassim TA, Clarke DD, Mai VQ, Clyde PW, Mohamed Shakir KM (2008). "Catecholamine-induced cardiomyopathy". Endocr Pract. 14 (9): 1137–49. doi:10.4158/EP.14.9.1137. PMID 19158054.
  5. Bravo EL (1994). "Evolving concepts in the pathophysiology, diagnosis, and treatment of pheochromocytoma". Endocr Rev. 15 (3): 356–68. doi:10.1210/edrv-15-3-356. PMID 8076587.
  6. Walther MM, Reiter R, Keiser HR, Choyke PL, Venzon D, Hurley K; et al. (1999). "Clinical and genetic characterization of pheochromocytoma in von Hippel-Lindau families: comparison with sporadic pheochromocytoma gives insight into natural history of pheochromocytoma". J Urol. 162 (3 Pt 1): 659–64. PMID 10458336.

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