FGF13: Difference between revisions

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{{Infobox_gene}}
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'''Fibroblast growth factor 13''' is a [[protein]] that in humans is encoded by the ''FGF13'' [[gene]].<ref name="pmid8790420">{{cite journal | vauthors = Smallwood PM, Munoz-Sanjuan I, Tong P, Macke JP, Hendry SH, Gilbert DJ, Copeland NG, Jenkins NA, Nathans J | title = Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development | journal = Proc Natl Acad Sci U S A | volume = 93 | issue = 18 | pages = 9850–7 |date=Oct 1996 | pmid = 8790420 | pmc = 38518 | doi =10.1073/pnas.93.18.9850 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: FGF13 fibroblast growth factor 13| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2258| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Fibroblast growth factor 13
| HGNCid = 3670
| Symbol = FGF13
| AltSymbols =; FGF2; FHF2
| OMIM = 300070
| ECnumber = 
| Homologene = 3036
| MGIid = 109178
| GeneAtlas_image1 = PBB_GE_FGF13_205110_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008083 |text = growth factor activity}} {{GNF_GO|id=GO:0030295 |text = protein kinase activator activity}}
| Component = {{GNF_GO|id=GO:0005615 |text = extracellular space}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0000165 |text = MAPKKK cascade}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0007399 |text = nervous system development}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2258
    | Hs_Ensembl = ENSG00000129682
    | Hs_RefseqProtein = NP_004105
    | Hs_RefseqmRNA = NM_004114
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = X
    | Hs_GenLoc_start = 137541401
    | Hs_GenLoc_end = 137894912
    | Hs_Uniprot = Q92913
    | Mm_EntrezGene = 14168
    | Mm_Ensembl = ENSMUSG00000031137
    | Mm_RefseqmRNA = XM_987459
    | Mm_RefseqProtein = XP_992553
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = X
    | Mm_GenLoc_start = 55408923
    | Mm_GenLoc_end = 55597751
    | Mm_Uniprot = Q3UR31
  }}
}}
'''Fibroblast growth factor 13''', also known as '''FGF13''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: FGF13 fibroblast growth factor 13| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2258| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This gene is located to a region associated with Borjeson-Forssman-Lehmann syndrome (BFLS), a syndromal X-linked mental retardation, which suggests it may be a candidate gene for familial cases of the BFL syndrome. The function of this gene has not yet been determined. Two alternatively spliced transcripts encoding different isoforms have been described for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: FGF13 fibroblast growth factor 13| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2258| accessdate = }}</ref>
| summary_text = The protein encoded by this gene is a member of the [[fibroblast growth factor]] (FGF) family. FGF family members possess broad [[mitogen]]ic and cell survival activities, and are involved in a variety of [[biological process]]es, including [[Embryogenesis|embryonic development]], [[cell growth]], [[morphogenesis]], [[tissue repair]], [[tumor]] growth, and invasion. This gene is located to a region associated with [[Börjeson-Forssman-Lehmann syndrome]] (BFLS), a syndromal X-linked [[intellectual disability]], which suggests it may be a candidate gene for familial cases of the BFL syndrome. The function of this gene has not yet been determined. Two alternatively spliced transcripts encoding different [[isoforms]] have been described for this gene.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Wittmack EK, Rush AM, Craner MJ, ''et al.'' |title=Fibroblast growth factor homologous factor 2B: association with Nav1.6 and selective colocalization at nodes of Ranvier of dorsal root axons. |journal=J. Neurosci. |volume=24 |issue= 30 |pages= 6765-75 |year= 2005 |pmid= 15282281 |doi= 10.1523/JNEUROSCI.1628-04.2004 }}
*{{cite journal  | vauthors=Wittmack EK, Rush AM, Craner MJ |title=Fibroblast growth factor homologous factor 2B: association with Nav1.6 and selective colocalization at nodes of Ranvier of dorsal root axons. |journal=J. Neurosci. |volume=24 |issue= 30 |pages= 6765–75 |year= 2005 |pmid= 15282281 |doi= 10.1523/JNEUROSCI.1628-04.2004 |display-authors=etal}}
*{{cite journal  | author=Popovici C, Conchonaud F, Birnbaum D, Roubin R |title=Functional phylogeny relates LET-756 to fibroblast growth factor 9. |journal=J. Biol. Chem. |volume=279 |issue= 38 |pages= 40146-52 |year= 2004 |pmid= 15199049 |doi= 10.1074/jbc.M405795200 }}
*{{cite journal  | vauthors=Popovici C, Conchonaud F, Birnbaum D, Roubin R |title=Functional phylogeny relates LET-756 to fibroblast growth factor 9. |journal=J. Biol. Chem. |volume=279 |issue= 38 |pages= 40146–52 |year= 2004 |pmid= 15199049 |doi= 10.1074/jbc.M405795200 }}
*{{cite journal  | author=Facchiano A, Russo K, Facchiano AM, ''et al.'' |title=Identification of a novel domain of fibroblast growth factor 2 controlling its angiogenic properties. |journal=J. Biol. Chem. |volume=278 |issue= 10 |pages= 8751-60 |year= 2003 |pmid= 12496262 |doi= 10.1074/jbc.M209936200 }}
*{{cite journal  | vauthors=Facchiano A, Russo K, Facchiano AM |title=Identification of a novel domain of fibroblast growth factor 2 controlling its angiogenic properties. |journal=J. Biol. Chem. |volume=278 |issue= 10 |pages= 8751–60 |year= 2003 |pmid= 12496262 |doi= 10.1074/jbc.M209936200 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Schoorlemmer J, Goldfarb M |title=Fibroblast growth factor homologous factors and the islet brain-2 scaffold protein regulate activation of a stress-activated protein kinase. |journal=J. Biol. Chem. |volume=277 |issue= 51 |pages= 49111-9 |year= 2003 |pmid= 12244047 |doi= 10.1074/jbc.M205520200 }}
*{{cite journal  | vauthors=Schoorlemmer J, Goldfarb M |title=Fibroblast growth factor homologous factors and the islet brain-2 scaffold protein regulate activation of a stress-activated protein kinase. |journal=J. Biol. Chem. |volume=277 |issue= 51 |pages= 49111–9 |year= 2003 |pmid= 12244047 |doi= 10.1074/jbc.M205520200 |pmc=4266389 }}
*{{cite journal  | author=Knox S, Merry C, Stringer S, ''et al.'' |title=Not all perlecans are created equal: interactions with fibroblast growth factor (FGF) 2 and FGF receptors. |journal=J. Biol. Chem. |volume=277 |issue= 17 |pages= 14657-65 |year= 2002 |pmid= 11847221 |doi= 10.1074/jbc.M111826200 }}
*{{cite journal  | vauthors=Knox S, Merry C, Stringer S |title=Not all perlecans are created equal: interactions with fibroblast growth factor (FGF) 2 and FGF receptors. |journal=J. Biol. Chem. |volume=277 |issue= 17 |pages= 14657–65 |year= 2002 |pmid= 11847221 |doi= 10.1074/jbc.M111826200 |display-authors=etal}}
*{{cite journal  | author=Munoz-Sanjuan I, Smallwood PM, Nathans J |title=Isoform diversity among fibroblast growth factor homologous factors is generated by alternative promoter usage and differential splicing. |journal=J. Biol. Chem. |volume=275 |issue= 4 |pages= 2589-97 |year= 2000 |pmid= 10644718 |doi=  }}
*{{cite journal  | vauthors=Munoz-Sanjuan I, Smallwood PM, Nathans J |title=Isoform diversity among fibroblast growth factor homologous factors is generated by alternative promoter usage and differential splicing. |journal=J. Biol. Chem. |volume=275 |issue= 4 |pages= 2589–97 |year= 2000 |pmid= 10644718 |doi=10.1074/jbc.275.4.2589 }}
*{{cite journal  | author=Gecz J, Baker E, Donnelly A, ''et al.'' |title=Fibroblast growth factor homologous factor 2 (FHF2): gene structure, expression and mapping to the Börjeson-Forssman-Lehmann syndrome region in Xq26 delineated by a duplication breakpoint in a BFLS-like patient. |journal=Hum. Genet. |volume=104 |issue= 1 |pages= 56-63 |year= 1999 |pmid= 10071193 |doi=  }}
*{{cite journal  | vauthors=Gecz J, Baker E, Donnelly A |title=Fibroblast growth factor homologous factor 2 (FHF2): gene structure, expression and mapping to the Börjeson-Forssman-Lehmann syndrome region in Xq26 delineated by a duplication breakpoint in a BFLS-like patient. |journal=Hum. Genet. |volume=104 |issue= 1 |pages= 56–63 |year= 1999 |pmid= 10071193 |doi=10.1007/s004390050910 |display-authors=etal}}
*{{cite journal  | author=Yao DL, Masonic K, Petullo D, ''et al.'' |title=Pretreatment with intravenous FGF-13 reduces infarct volume and ameliorates neurological deficits following focal cerebral ischemia in rats. |journal=Brain Res. |volume=818 |issue= 1 |pages= 140-6 |year= 1999 |pmid= 9914447 |doi=  }}
*{{cite journal  | vauthors=Yao DL, Masonic K, Petullo D |title=Pretreatment with intravenous FGF-13 reduces infarct volume and ameliorates neurological deficits following focal cerebral ischemia in rats. |journal=Brain Res. |volume=818 |issue= 1 |pages= 140–6 |year= 1999 |pmid= 9914447 |doi=10.1016/S0006-8993(98)01118-4 |display-authors=etal}}
*{{cite journal  | author=Greene JM, Li YL, Yourey PA, ''et al.'' |title=Identification and characterization of a novel member of the fibroblast growth factor family. |journal=Eur. J. Neurosci. |volume=10 |issue= 5 |pages= 1911-25 |year= 1998 |pmid= 9751161 |doi= }}
*{{cite journal  | vauthors=Greene JM, Li YL, Yourey PA |title=Identification and characterization of a novel member of the fibroblast growth factor family. |journal=Eur. J. Neurosci. |volume=10 |issue= 5 |pages= 1911–25 |year= 1998 |pmid= 9751161 |doi=10.1046/j.1460-9568.1998.00211.x  |display-authors=etal}}
*{{cite journal  | author=Smallwood PM, Munoz-Sanjuan I, Tong P, ''et al.'' |title=Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 18 |pages= 9850-7 |year= 1996 |pmid= 8790420 |doi=  }}
}}
}}
{{refend}}
{{refend}}


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{{Growth factors}}
{{Growth factor receptor modulators}}
 
 
{{gene-X-stub}}

Latest revision as of 22:06, 11 July 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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RefSeq (mRNA)

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Location (UCSC)n/an/a
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Wikidata
View/Edit Human

Fibroblast growth factor 13 is a protein that in humans is encoded by the FGF13 gene.[1][2]

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This gene is located to a region associated with Börjeson-Forssman-Lehmann syndrome (BFLS), a syndromal X-linked intellectual disability, which suggests it may be a candidate gene for familial cases of the BFL syndrome. The function of this gene has not yet been determined. Two alternatively spliced transcripts encoding different isoforms have been described for this gene.[2]

References

  1. ↑ Smallwood PM, Munoz-Sanjuan I, Tong P, Macke JP, Hendry SH, Gilbert DJ, Copeland NG, Jenkins NA, Nathans J (Oct 1996). "Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development". Proc Natl Acad Sci U S A. 93 (18): 9850–7. doi:10.1073/pnas.93.18.9850. PMC 38518. PMID 8790420.
  2. ↑ 2.0 2.1 "Entrez Gene: FGF13 fibroblast growth factor 13".

Further reading



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