Use in immunology
Mitogens are often used to stimulate lymphocytes and therefore assess immune function.
The most commonly used mitogens in clinical laboratory medicine are:
|Name||Acts upon T cells?||Acts upon B cells?|
|concanavalin A (conA)||yes||no|
|pokeweed mitogen (PWM)||yes||yes|
Plasma B cells are terminally differentiated and therefore cannot undergo mitosis. Memory B cells can proliferate to produce more memory cells or plasma B cells. This is how the mitogen works, by inducing mitosis in B cells to cause them to divide, with some becoming plasma cells.
- Mitogens at the US National Library of Medicine Medical Subject Headings (MeSH)
- Mitogen at eMedicine Dictionary
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