Edoxaban

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Edoxaban
	File:Edoxaban skeletal.svg
Clinical data
ATC code	none;
Identifiers
	IUPAC name N'-(5-chloropyridin-2-yl)-N-[(1S,2R,4S)-4-(dimethylcarbamoyl)-2-[(5-methyl-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine-2-carbonyl)amino]cyclohexyl]oxamide;
CAS Number	912273-65-5;
PubChem CID	25022378;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C24H30ClN7O4S
Molar mass	548.056 g/mol

Edoxaban (INN, codenamed DU-176b) is an anticoagulant drug which acts as a direct factor Xa inhibitor. It is being developed by Daiichi Sankyo. In animal studies, edoxaban is potent, selective for factor Xa and has good oral bioavailability,^[1] but it has not been approved for use in humans.^[2]

Several Phase II clinical trials have been conducted, for example for thromboprophylaxis after total hip replacement^[3] and for stroke prevention in patients with atrial fibrillation^[4].

References

↑ Furugohri T, Isobe K, Honda Y, Kamisato-Matsumoto C, Sugiyama N, Nagahara T, Morishima Y, Shibano T (2008). "DU-176b, a potent and orally active factor Xa inhibitor: in vitro and in vivo pharmacological profiles". Journal of Thrombosis and Haemostasis : JTH. 6 (9): 1542–9. doi:10.1111/j.1538-7836.2008.03064.x. PMID 18624979. Unknown parameter |month= ignored (help)
↑ Sobieraj-Teague M, O'Donnell M, Eikelboom J (2009). "New anticoagulants for atrial fibrillation". Seminars in Thrombosis and Hemostasis. 35 (5): 515–24. doi:10.1055/s-0029-1234147. PMID 19739042. Unknown parameter |month= ignored (help)
↑ PMID 20589317
↑ PMID 20694273

Template:WH Template:WS

[pmid18624979-1] Furugohri T, Isobe K, Honda Y, Kamisato-Matsumoto C, Sugiyama N, Nagahara T, Morishima Y, Shibano T (2008). "DU-176b, a potent and orally active factor Xa inhibitor: in vitro and in vivo pharmacological profiles". Journal of Thrombosis and Haemostasis : JTH. 6 (9): 1542–9. doi:10.1111/j.1538-7836.2008.03064.x. PMID 18624979. Unknown parameter |month= ignored (help)

[pmid19739042-2] Sobieraj-Teague M, O'Donnell M, Eikelboom J (2009). "New anticoagulants for atrial fibrillation". Seminars in Thrombosis and Hemostasis. 35 (5): 515–24. doi:10.1055/s-0029-1234147. PMID 19739042. Unknown parameter |month= ignored (help)

[3] PMID 20589317

[4] PMID 20694273

[1]

[2]

[3]

[4]

Clinical data
File:Edoxaban skeletal.svg
ATC code	none
Identifiers
IUPAC name N'-(5-chloropyridin-2-yl)-N-[(1S,2R,4S)-4-(dimethylcarbamoyl)-2-[(5-methyl-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine-2-carbonyl)amino]cyclohexyl]oxamide
CAS Number	912273-65-5
PubChem CID	25022378
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C₂₄H₃₀ClN₇O₄S
Molar mass	548.056 g/mol

Edoxaban

References

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