Danaparoid

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Danaparoid
Systematic (IUPAC) name
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Identifiers
CAS number	?
ATC code	B01AB09
PubChem	?
Chemical data
Formula	?
Mol. mass	?
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

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Danaparoid sodium (Orgaran®) is an anticoagulant that works by inhibiting activated factor X (factor Xa).

Danaparoid is considered a "low molecular weight heparin" by some sources, but is chemically distinct from heparin and thus has little cross-reactivity in heparin-intolerant patients.

Uses

It is used to prevent deep venous clots, particularly in situations with a high risk of clot formation, such as after hip surgery.

It is also used as a heparinoid substitute in heparin-induced thrombocytopenia which may otherwise cause paradoxical thrombosis.

Discontinuation

On August 14, 2002, this drug was withdrawn by Organon International.^[1]

Administration

IV IV and SC

Side effects

• Bleeding problems
• Low platelets, due to a low level of structural similarity between danaparoid and heparin
• Asthma exacerbations, due to allergies to sulphites contained within the medicine

References

External links

• MeSH danaparoid

v • d • e Antithrombotics (thrombolytics, anticoagulants and antiplatelet drugs) (B01)
Vitamin K antagonists	Acenocoumarol • Clorindione • Coumatetralyl • Dicumarol (Dicoumarol) • Diphenadione • Ethyl biscoumacetate • Phenprocoumon • Phenindione • Tioclomarol • Warfarin
Heparin group	Antithrombin III • Danaparoid • Heparin • Sulodexide • low molecular weight heparin (Bemiparin, Dalteparin, Enoxaparin, Nadroparin, Parnaparin, Reviparin, Tinzaparin)
Glycoprotein IIb/IIIa inhibitors	Abciximab • Eptifibatide • Tirofiban
Other platelet aggregation inhibitors	Acetylsalicylic acid/Aspirin • Aloxiprin • Ditazole • Carbasalate calcium • Cloricromen • Dipyridamole • Indobufen • Picotamide • Triflusal • ADP receptor inhibitors (Clopidogrel, Ticlopidine, Prasugrel) • prostaglandin analogue (Beraprost, Prostacyclin, Iloprost, Treprostinil)
Enzymes	plasminogen activators (Alteplase/Reteplase/Tenecteplase, Streptokinase, Urokinase/Saruplase, Anistreplase) • other serine endopeptidases (Ancrod, Drotrecogin alfa/Protein C, Fibrinolysin) • Brinase
Direct thrombin inhibitors	Argatroban • Bivalirudin • Dabigatran • Desirudin • Hirudin • Lepirudin • Melagatran • Ximelagatran
Other antithrombotics	Apixaban • Defibrotide • Dermatan sulfate • Fondaparinux • Idraparinux • Otamixaban • Rivaroxaban
Non-medicinal	Citrate • EDTA • Oxalate

v • d • e WikiDoc Research Resources for Danaparoid
Articles on Danaparoid	Most recent articles on Danaparoid • Most cited articles on Danaparoid • Review articles on Danaparoid • Articles on Danaparoid in N Eng J Med, Lancet, BMJ
Media (Slides, Video, Images, MP3) on Danaparoid	Powerpoint slides on Danaparoid • Images of Danaparoid • Photos of Danaparoid • Podcasts & MP3s on Danaparoid • Videos on Danaparoid
Evidence Based Medicine Regarding Danaparoid	Cochrane Collaboration on Danaparoid • Bandolier on Danaparoid • TRIP on Danaparoid
Cost Effectiveness of Danaparoid	Cost Effectiveness of Danaparoid
Clinical Trials Involving Danaparoid	Ongoing Trials on Danaparoid at Clinical Trials.gov • Trial results on Danaparoid • Clinical Trials on Danaparoid at Google
Guidelines / Policies / Government Resources (FDA/CDC) Regarding Danaparoid	US National Guidelines Clearinghouse on Danaparoid • NICE Guidance on Danaparoid • NHS PRODIGY Guidance • FDA on Danaparoid • CDC on Danaparoid
Textbook Information on Danaparoid	Books and Textbook Information on Danaparoid
Pharmacology Resources on Danaparoid	Dosing of Danaparoid • Drug interactions with Danaparoid • Side effects of Danaparoid • Allergic reactions to Danaparoid • Overdose information on Danaparoid • Carcinogenicity information on Danaparoid • Danaparoid in pregnancy • Pharmacokinetics of Danaparoid •
Genetics, Pharmacogenomics, and Proteinomics of Danaparoid	Genetics of Danaparoid • Pharmacogenomics of Danaparoid • Proteomics of Danaparoid
Newstories on Danaparoid	Danaparoid in the news • Be alerted to news on Danaparoid • News trends on Danaparoid
Commentary on Danaparoid	Blogs on Danaparoid
Patient Resources on Danaparoid	Patient resources on Danaparoid • Discussion groups on Danaparoid • Patient Handouts on Danaparoid • Directions to Hospitals Treating Danaparoid • Risk calculators and risk factors for Danaparoid
Healthcare Provider Resources on Danaparoid	Symptoms of Danaparoid • Causes & Risk Factors for Danaparoid • Diagnostic studies for Danaparoid • Treatment of Danaparoid
Continuing Medical Education (CME) Programs on Danaparoid	CME Programs on Danaparoid
International Resources on Danaparoid	Danaparoid en Espanol • Danaparoid en Francais
Business Resources on Danaparoid	Danaparoid in the Marketplace • Patents on Danaparoid
Informatics Resources on Danaparoid	List of terms related to Danaparoid

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Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .