Dicumarol

Dicumarol

Clinical data
ATC code	B01AA01 (WHO)
Pharmacokinetic data
Protein binding	plasmatic proteins
Metabolism	hepatic
Excretion	faeces, urine
Identifiers
IUPAC name 3,3'-methylenebis(4-hydroxy-2H-chromen-2-one)
CAS Number	66-76-2
PubChem CID	653
DrugBank	APRD00761
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C19H12O6
Molar mass	336.295 g/mol

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

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Dicumarol (or Dicoumarol) is an anticoagulant that functions by as a Vitamin K antagonist (similar to warfarin).

It is a derivative of coumarin.

External links

• Template:DiseasesDB
• Cullen J, Hinkhouse M, Grady M, Gaut A, Liu J, Zhang Y, Weydert C, Domann F, Oberley L (2003). "Dicumarol inhibition of NADPH: quinone oxidoreductase induces growth inhibition of pancreatic cancer via a superoxide-mediated mechanism". Cancer Res. 63 (17): 5513–20. PMID 14500388.CS1 maint: Multiple names: authors list (link)
• Mironov A, Colanzi A, Polishchuk R, Beznoussenko G, Mironov A, Fusella A, Di Tullio G, Silletta M, Corda D, De Matteis M, Luini A (2004). "Dicumarol, an inhibitor of ADP-ribosylation of CtBP3/BARS, fragments golgi non-compact tubular zones and inhibits intra-golgi transport". Eur J Cell Biol. 83 (6): 263–79. PMID 15511084.CS1 maint: Multiple names: authors list (link)
• Abdelmohsen K, Stuhlmann D, Daubrawa F, Klotz L (2005). "Dicumarol is a potent reversible inhibitor of gap junctional intercellular communication". Arch Biochem Biophys. 434 (2): 241–7. PMID 15639223.CS1 maint: Multiple names: authors list (link)
• Thanos C, Liu Z, Reineke J, Edwards E, Mathiowitz E (2003). "Improving relative bioavailability of dicumarol by reducing particle size and adding the adhesive poly(fumaric-co-sebacic) anhydride". Pharm Res. 20 (7): 1093–100. PMID 12880296.CS1 maint: Multiple names: authors list (link)

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