Dicumarol

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Dicumarol
Systematic (IUPAC) name
3,3'-methylenebis(4-hydroxy-2H-chromen-2-one)
Identifiers
CAS number	66-76-2
ATC code	B01AA01
PubChem	653
DrugBank	APRD00761
Chemical data
Formula	C19H12O6
Mol. mass	336.295 g/mol
Pharmacokinetic data
Bioavailability	?
Protein binding	plasmatic proteins
Metabolism	hepatic
Half life	?
Excretion	faeces, urine
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

WikiDoc Resources for Dicumarol
Articles
Most recent articles on Dicumarol Most cited articles on Dicumarol Review articles on Dicumarol Articles on Dicumarol in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Dicumarol Images of Dicumarol Photos of Dicumarol Podcasts & MP3s on Dicumarol Videos on Dicumarol
Evidence Based Medicine
Cochrane Collaboration on Dicumarol Bandolier on Dicumarol TRIP on Dicumarol
Clinical Trials
Ongoing Trials on Dicumarol at Clinical Trials.gov Trial results on Dicumarol Clinical Trials on Dicumarol at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Dicumarol NICE Guidance on Dicumarol NHS PRODIGY Guidance FDA on Dicumarol CDC on Dicumarol
Books
Books on Dicumarol
News
Dicumarol in the news Be alerted to news on Dicumarol News trends on Dicumarol
Commentary
Blogs on Dicumarol
Definitions
Definitions of Dicumarol
Patient Resources / Community
Patient resources on Dicumarol Discussion groups on Dicumarol Patient Handouts on Dicumarol Directions to Hospitals Treating Dicumarol Risk calculators and risk factors for Dicumarol
Healthcare Provider Resources
Symptoms of Dicumarol Causes & Risk Factors for Dicumarol Diagnostic studies for Dicumarol Treatment of Dicumarol
Continuing Medical Education (CME)
CME Programs on Dicumarol
International
Dicumarol en Espanol Dicumarol en Francais
Businness
Dicumarol in the Marketplace Patents on Dicumarol
Experimental / Informatics
List of terms related to Dicumarol

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For patient information, click here

Dicumarol (or Dicoumarol) is an anticoagulant that functions by as a Vitamin K antagonist (similar to warfarin).

It is a derivative of coumarin.

External links

• DDB 30166
• Cullen J, Hinkhouse M, Grady M, Gaut A, Liu J, Zhang Y, Weydert C, Domann F, Oberley L (2003). "Dicumarol inhibition of NADPH: quinone oxidoreductase induces growth inhibition of pancreatic cancer via a superoxide-mediated mechanism.". Cancer Res 63 (17): 5513-20. PMID 14500388.
• Mironov A, Colanzi A, Polishchuk R, Beznoussenko G, Mironov A, Fusella A, Di Tullio G, Silletta M, Corda D, De Matteis M, Luini A (2004). "Dicumarol, an inhibitor of ADP-ribosylation of CtBP3/BARS, fragments golgi non-compact tubular zones and inhibits intra-golgi transport.". Eur J Cell Biol 83 (6): 263-79. PMID 15511084.
• Abdelmohsen K, Stuhlmann D, Daubrawa F, Klotz L (2005). "Dicumarol is a potent reversible inhibitor of gap junctional intercellular communication.". Arch Biochem Biophys 434 (2): 241-7. PMID 15639223.
• Thanos C, Liu Z, Reineke J, Edwards E, Mathiowitz E (2003). "Improving relative bioavailability of dicumarol by reducing particle size and adding the adhesive poly(fumaric-co-sebacic) anhydride.". Pharm Res 20 (7): 1093-100. PMID 12880296.

v • d • e Antithrombotics (thrombolytics, anticoagulants and antiplatelet drugs) (B01)
Vitamin K antagonists	Acenocoumarol • Clorindione • Coumatetralyl • Dicumarol (Dicoumarol) • Diphenadione • Ethyl biscoumacetate • Phenprocoumon • Phenindione • Tioclomarol • Warfarin
Heparin group	Antithrombin III • Danaparoid • Heparin • Sulodexide • low molecular weight heparin (Bemiparin, Dalteparin, Enoxaparin, Nadroparin, Parnaparin, Reviparin, Tinzaparin)
Glycoprotein IIb/IIIa inhibitors	Abciximab • Eptifibatide • Tirofiban
Other platelet aggregation inhibitors	Acetylsalicylic acid/Aspirin • Aloxiprin • Ditazole • Carbasalate calcium • Cloricromen • Dipyridamole • Indobufen • Picotamide • Triflusal • ADP receptor inhibitors (Clopidogrel, Ticlopidine, Prasugrel) • prostaglandin analogue (Beraprost, Prostacyclin, Iloprost, Treprostinil)
Enzymes	plasminogen activators (Alteplase/Reteplase/Tenecteplase, Streptokinase, Urokinase/Saruplase, Anistreplase) • other serine endopeptidases (Ancrod, Drotrecogin alfa/Protein C, Fibrinolysin) • Brinase
Direct thrombin inhibitors	Argatroban • Bivalirudin • Dabigatran • Desirudin • Hirudin • Lepirudin • Melagatran • Ximelagatran
Other antithrombotics	Apixaban • Defibrotide • Dermatan sulfate • Fondaparinux • Idraparinux • Otamixaban • Rivaroxaban
Non-medicinal	Citrate • EDTA • Oxalate

v • d • e WikiDoc Research Resources for Dicumarol (Click show to right to view)
Articles on Dicumarol	Most recent articles on Dicumarol • Most cited articles on Dicumarol • Review articles on Dicumarol • Articles on Dicumarol in N Eng J Med, Lancet, BMJ
Media (Slides, Video, Images, MP3) on Dicumarol	Powerpoint slides on Dicumarol • Images of Dicumarol • Photos of Dicumarol • Podcasts & MP3s on Dicumarol • Videos on Dicumarol
Evidence Based Medicine Regarding Dicumarol	Cochrane Collaboration on Dicumarol • Bandolier on Dicumarol • TRIP on Dicumarol
Cost Effectiveness of Dicumarol	Cost Effectiveness of Dicumarol
Clinical Trials Involving Dicumarol	Ongoing Trials on Dicumarol at Clinical Trials.gov • Trial results on Dicumarol • Clinical Trials on Dicumarol at Google
Guidelines / Policies / Government Resources (FDA/CDC) Regarding Dicumarol	US National Guidelines Clearinghouse on Dicumarol • NICE Guidance on Dicumarol • NHS PRODIGY Guidance • FDA on Dicumarol • CDC on Dicumarol
Textbook Information on Dicumarol	Books and Textbook Information on Dicumarol
Pharmacology Resources on Dicumarol	Dosing of Dicumarol • Drug interactions with Dicumarol • Side effects of Dicumarol • Allergic reactions to Dicumarol • Overdose information on Dicumarol • Carcinogenicity information on Dicumarol • Dicumarol in pregnancy • Pharmacokinetics of Dicumarol •
Genetics, Pharmacogenomics, and Proteinomics of Dicumarol	Genetics of Dicumarol • Pharmacogenomics of Dicumarol • Proteomics of Dicumarol
Newstories on Dicumarol	Dicumarol in the news • Be alerted to news on Dicumarol • News trends on Dicumarol
Commentary on Dicumarol	Blogs on Dicumarol
Patient Resources on Dicumarol	Patient resources on Dicumarol • Discussion groups on Dicumarol • Patient Handouts on Dicumarol • Directions to Hospitals Treating Dicumarol • Risk calculators and risk factors for Dicumarol
Healthcare Provider Resources on Dicumarol	Symptoms of Dicumarol • Causes & Risk Factors for Dicumarol • Diagnostic studies for Dicumarol • Treatment of Dicumarol
Continuing Medical Education (CME) Programs on Dicumarol	CME Programs on Dicumarol
International Resources on Dicumarol	Dicumarol en Espanol • Dicumarol en Francais
Business Resources on Dicumarol	Dicumarol in the Marketplace • Patents on Dicumarol
Informatics Resources on Dicumarol	List of terms related to Dicumarol

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Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .