Edoxaban: Difference between revisions

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Revision as of 18:52, 27 September 2011

Edoxaban
File:Edoxaban skeletal.svg
Clinical data
ATC code
  • none
Identifiers
CAS Number
PubChem CID
E number{{#property:P628}}
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Chemical and physical data
FormulaC24H30ClN7O4S
Molar mass548.056 g/mol

WikiDoc Resources for Edoxaban

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Edoxaban (INN, codenamed DU-176b) is an anticoagulant drug which acts as a direct factor Xa inhibitor. It is being developed by Daiichi Sankyo. In animal studies, edoxaban is potent, selective for factor Xa and has good oral bioavailability,[1] but it has not been approved for use in humans.[2]

Several Phase II clinical trials have been conducted, for example for thromboprophylaxis after total hip replacement[3] and for stroke prevention in patients with atrial fibrillation[4].

References

  1. Furugohri T, Isobe K, Honda Y, Kamisato-Matsumoto C, Sugiyama N, Nagahara T, Morishima Y, Shibano T (2008). "DU-176b, a potent and orally active factor Xa inhibitor: in vitro and in vivo pharmacological profiles". Journal of Thrombosis and Haemostasis : JTH. 6 (9): 1542–9. doi:10.1111/j.1538-7836.2008.03064.x. PMID 18624979. Unknown parameter |month= ignored (help)
  2. Sobieraj-Teague M, O'Donnell M, Eikelboom J (2009). "New anticoagulants for atrial fibrillation". Seminars in Thrombosis and Hemostasis. 35 (5): 515–24. doi:10.1055/s-0029-1234147. PMID 19739042. Unknown parameter |month= ignored (help)
  3. PMID 20589317
  4. PMID 20694273

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