Tiagabine
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| Image:Tiagabine.svg | |
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| Tiagabine
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| Systematic (IUPAC) name | |
| (3S)-1-[4,4-bis(3-methylthiophen-2-yl)but-3-enyl] piperidine-3-carboxylic acid | |
| Identifiers | |
| CAS number | |
| ATC code | N03 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C20H25NO2S2 |
| Mol. mass | 375.55 g/mol |
| Pharmacokinetic data | |
| Bioavailability | 90% |
| Protein binding | 96% |
| Metabolism | Hepatic (CYP450 system) |
| Half life | 7-9 hours |
| Excretion | Fecal and renal |
| Therapeutic considerations | |
| Pregnancy cat. | |
| Legal status | |
| Routes | Oral |
Tiagabine (IPA: [ˌtɪəgəˈbin]) is an anti-convulsive medication produced by Cephalon Inc. and marketed under the brand name Gabitril. The medication is also used in the treatment for panic disorder as are a few other anticonvulsants.
Though the exact mechanism by which tiagabine exerts its effect on the human body is unknown, it does appear to operate as a selective GABA reuptake inhibitor.
Side effects
Tiagabine's most common side effects include confusion, difficulty speaking clearly/stuttering, mild sedation, and in doses over 8 mg, a tingling sensation (paraphasia) in the body's extremities, particularly the hands and fingers.
External links
- Gabitril (manufacturer's website)
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
