Porphobilinogen synthase
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| Porphobilinogen synthase
| |
| Identifiers | |
| Symbol | ALAD |
| Entrez | 210 |
| HUGO | 395 |
| OMIM | 125270 |
| RefSeq | NM_001003945 |
| UniProt | P13716 |
| Other data | |
| EC number | 4.2.1.24 |
| Locus | Chr. 9 q32 |
Porphobilinogen synthase (or ALA dehydratase, or Aminolevulinate dehydratase) synthesizes porphobilinogen through the asymmetric condensation of two molecules of aminolevulinic acid. All natural tetrapyrroles, including hemes, chlorophylls and vitamin B12, share porphobilinogen as a common precursor.
It is involved in the second step of the metabolism of porphyrin.
Pathology
Lead poisoning works on the cellular level by binding to this enzyme, rendering it useless.
External links
Metabolism: amino acid metabolism - porphyrin enzymes | |
|---|---|
| Porphyrin biosynthesis | initial mitochondrial: Aminolevulinic acid synthase - Porphobilinogen synthase
cytosolic: Porphobilinogen deaminase - Uroporphyrinogen III synthase - Uroporphyrinogen III decarboxylase - Coproporphyrinogen III oxidase terminal mitochondrial: Protoporphyrinogen oxidase - Ferrochelatase |
| Heme breakdown to bile | spleen: Heme oxygenase - Biliverdin reductase liver: UDP-glucuronosyltransferase |
| see also disorders, intermediates | |
Carbon-oxygen lyases (EC 4.2) (primarily dehydratases) |
|---|
| Carbonic anhydrase - Fumarase - Aconitase - Enolase (Alpha) - Enoyl-CoA hydratase/3-Hydroxyacyl ACP dehydrase - Methylglutaconyl-CoA hydratase - Tryptophan synthase - Cystathionine beta synthase - Porphobilinogen synthase - 3-isopropylmalate dehydratase - Urocanate hydratase - Uroporphyrinogen III synthase - Nitrile hydratase |
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
