Protoporphyrinogen oxidase
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| protoporphyrinogen oxidase
| |
| Identifiers | |
| Symbol | PPOX |
| Alt. Symbols | VP |
| Entrez | 5498 |
| HUGO | 9280 |
| OMIM | 600923 |
| RefSeq | NM_000309 |
| UniProt | P50336 |
| Other data | |
| EC number | 1.3.3.4 |
| Locus | Chr. 1 q22 |
Protoporphyrinogen oxidase (EC 1.3.3.4) is an enzyme that is responsible for the seventh step in heme production. (Heme is the portion of hemoglobin that carries oxygen in the blood from the lungs to the rest of the body.)
Protoporphyrinogen oxidase removes hydrogen atoms from protoporphyrinogen IX (the product of the sixth step in the production of heme) to form protoporphyrin IX.
One additional enzyme must modify protoporphyrin IX before it becomes heme.
See also
Oxidoreductases: CH-CH oxidoreductases (EC 1.3) | |
|---|---|
| 1.3.1. NAD/NADP acceptor | Enoyl-acyl carrier protein reductase/Enoyl ACP reductase - 7-Dehydrocholesterol reductase - Biliverdin reductase - 2,4 Dienoyl-CoA reductase |
| 1.3.3. Oxygen acceptor | Dihydroorotate dehydrogenase - Coproporphyrinogen III oxidase - Protoporphyrinogen oxidase - |
| 1.3.5. Quinone | Succinate - coenzyme Q reductase |
| 1.3.99. Other acceptors | Fumarate reductase - Butyryl CoA dehydrogenase - Acyl CoA dehydrogenase - 5-alpha reductase - Glutaryl-CoA dehydrogenase - Isovaleryl coenzyme A dehydrogenase |
Metabolism: amino acid metabolism - porphyrin enzymes | |
|---|---|
| Porphyrin biosynthesis | initial mitochondrial: Aminolevulinic acid synthase - Porphobilinogen synthase
cytosolic: Porphobilinogen deaminase - Uroporphyrinogen III synthase - Uroporphyrinogen III decarboxylase - Coproporphyrinogen III oxidase terminal mitochondrial: Protoporphyrinogen oxidase - Ferrochelatase |
| Heme breakdown to bile | spleen: Heme oxygenase - Biliverdin reductase liver: UDP-glucuronosyltransferase |
| see also disorders, intermediates | |
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
