Dipeptide
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A dipeptide is a molecule consisting of two amino acids joined by a single peptide bond.
Dipeptides are produced from polypeptides by the action of the hydrolase enzyme dipeptidyl peptidase. Dietary proteins are digested to dipeptides and amino acids, and the dipeptides are absorbed more rapidly than the amino acids, because their uptake involves a separate mechanism. Dipeptides activate G-cells found in the stomach to secrete gastrin.
The Bergmann azlactone peptide synthesis is a classic organic synthesis for the preparation of dipeptides. [1] [2]
Examples of dipeptides
- Carnosine (beta-alanyl-L-histidine) is highly concentrated in muscle and brain tissues.
- Anserine (beta-alanyl-N-methyl histidine) is found in the skeletal muscle and brain of mammals.
- Homoanserine (N-(4-Aminobutyryl)-L-histidine) is another dipeptide identified in the brain and muscles of mammals.
- Kyotorphin (L-tyrosyl-L-arginine) is a neuroactive dipeptide which plays a role in pain regulation in the brain.
- Balenine (or ophidine) (beta-alanyl-N tau-methyl histidine) has been identified in the muscles of several species of mammal (including man), and the chicken.
- Aspartame (N-L-a-aspartyl-L-phenylalanine 1-methyl ester) is an artificial sweetener.
- Glorin (N- propionyl-γ-L-glutamyl-L-ornithine-δ-lac ethyl ester) is a chemotactic dipeptide for the slime-mould Polysphondylium violaceum.
- Barettin (cyclo-[(6-bromo-8-en-tryptophan)-arginine]) is a cyclic dipeptide from the marine sponge Geodia barretti.
- Pseudoproline
See also
References
Types of Peptides | ||
|---|---|---|
| General: | Genetic code | Protein | Dipeptide | Tripeptide | Tetrapeptide | Oxytocin | Vasopressin | Calcitonin | Amylin | HPP | NPY | PYY | Glucagon | Secretin | VIP | Substance P | Kassinin | Eledoisin | Bradykinin | Adrenocorticotrophic hormone | |
| MSHs: | Proopiomelanocortin | Melanotan | |
| Others: | Endorphin | Lipotropin | Glutathione | Thyrotropin-releasing hormone | Carnosine | Anserine | Kyotorphin | Tentoxin | Tuftsin | Corticotropin-releasing hormone | |
| Major families of biochemicals | ||
| Peptides | Amino acids | Nucleic acids | Carbohydrates | Nucleotide sugars | Lipids | Terpenes | Carotenoids | Tetrapyrroles | Enzyme cofactors | Steroids | Flavonoids | Alkaloids | Polyketides | Glycosides | ||
| Analogues of nucleic acids: | Analogues of nucleic acids: | |
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
