|Locus:||Chr. 7 q31-q34|
Bisphosphoglycerate mutase (BPGM) catalyzes the conversion of 1,3-bisphosphoglycerate (1,3-BPG) to 2,3-bisphosphoglycerate (2,3-BPG). This enzyme should not be confused with Phosphoglycerate mutase (PGM) which plays a major role in glycolysis.
While 1,3-BPG is an important intermediate in Glycolysis, 2,3-BPG is not. 2,3-BPG does have an important role in erythrocytes, acting as an allosteric inhibitor of hemoglobin. The binding of 2,3-BPG decreases hemoglobin's affinity for oxygen and facilitates the transfer of O2 to tissues. BPGM plays an important role in erythrocytes, diverting up to 20% of the total glycolytic flux in order to maintain concentrations of 2,3-BPG that are roughly equal to concentrations of hemoglobin.
Excess amounts of 2,3-BPG can re-enter the glycolytic pathway through a phosphatase catalyzed conversion to glycerate 3-phosphate (G3P). This two-step process parallels Step 7 of main glycolytic pathway in which 1,3-BPG is converted directly to G3P with the phosphorylation of ADP to form ATP. The two-step BPGM/phosphatase pathway doesn't generate ATP and is therefore an inefficient way to arrive at G3P.
- Fujita T et al (1998). "Human erythrocyte bisphosphoglycerate mutase: inactivation by glycation in vivo and in vitro". J Biochem (Tokyo) 124 (6): 1237-44. PMID 9832630.
- MeSH Bisphosphoglycerate+mutase
Isomerase: mutases (EC 5.4)
|5.4.2 Phosphomutases||Phosphoglycerate mutase - Bisphosphoglycerate mutase - Phosphoglucomutase|
|5.4.99 Other groups||Methylmalonyl-CoA mutase - Lanosterol synthase|
Carbohydrate metabolism: glycolysis/gluconeogenesis enzymes
|Glycolysis||Glucokinase/Hexokinase/Glucose 6-phosphatase - Glucose isomerase - Phosphofructokinase 1/Fructose 1,6-bisphosphatase - Aldolase - Triosephosphate isomerase - Glyceraldehyde 3-phosphate dehydrogenase - Phosphoglycerate kinase - Phosphoglycerate mutase - Enolase - Pyruvate kinase|
|Gluconeogenesis only||Pyruvate carboxylase - Phosphoenolpyruvate carboxykinase - from lactate (Cori cycle): Lactate dehydrogenase - from alanine (Alanine cycle): Alanine transaminase|
|Regulatory||Phosphofructokinase 2/Fructose 2,6-bisphosphatase - Bisphosphoglycerate mutase|
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