Glucose 6-phosphatase is an enzyme in the gluconeogenesis pathway that removes the phosphate from glucose 6-phosphate, (where the goal is to increase free glucose in the blood due to the body being in the catabolic state).
Glucose 6-phosphatase is found in the liver and kidney and is involved in the organs' role in glucose homeostasis. Glucose-6-phosphatase is located on the inner membrane of the endoplasmic reticulum of the liver and kidney. Muscle and brain do not contain glucose 6-phosphatase; as a result any glucose 6-phosphate produced by glycogenolysis is used to generate ATP via glycolysis.
According to Surholt and Newsholme, glucose 6-phosphatase activity IS present in a wide variety of muscles across the animal kingdom.
A deficiency in glucose 6-phosphatase can lead to a glycogen storage disease called von Gierke's disease.
- ↑ Surholt B, Newsholme E (1981). "Maximum activities and properties of glucose 6-phosphatase in muscles from vertebrates and invertebrates". Biochem J 198 (3): 621-9. PMID 6275855.
Hydrolase: esterases (EC 3.1)
|3.1.1: Carboxylic ester hydrolases||Cholinesterase - Pectinesterase - 6-phosphogluconolactonase - PAF acetylhydrolase Phospholipase (A1, A2, B)|
|3.1.2: Thioesterase||Palmitoyl thioesterase - Ubiquitin carboxy-terminal hydrolase L1|
|3.1.3: Phosphatase||Alkaline phosphatase - Acid phosphatase (Prostatic)/Tartrate resistant acid phosphatase/Purple acid phosphatases - Nucleotidase - Glucose 6-phosphatase - Fructose 1,6-bisphosphatase - Calcineurin - Phosphoprotein phosphatase (PP2A) - OCRL - Pyruvate dehydrogenase phosphatase - Fructose 2,6-bisphosphatase - Protein tyrosine phosphatase - PTEN|
|3.1.4: Phosphodiesterase||Autotaxin - Phospholipase (C, D) - Sphingomyelin phosphodiesterase - PDE1 - PDE2 - PDE3 - PDE5|
|3.1.6: Sulfatase||Arylsulfatase B - Steroid sulfatase - Galactosamine-6 sulfatase - Arylsulfatase A - Iduronate-2-sulfatase - N-acetylglucosamine-6-sulfatase|
Carbohydrate metabolism: glycolysis/gluconeogenesis enzymes
|Glycolysis||Glucokinase/Hexokinase/Glucose 6-phosphatase - Glucose isomerase - Phosphofructokinase 1/Fructose 1,6-bisphosphatase - Aldolase - Triosephosphate isomerase - Glyceraldehyde 3-phosphate dehydrogenase - Phosphoglycerate kinase - Phosphoglycerate mutase - Enolase - Pyruvate kinase|
|Gluconeogenesis only||Pyruvate carboxylase - Phosphoenolpyruvate carboxykinase - from lactate (Cori cycle): Lactate dehydrogenase - from alanine (Alanine cycle): Alanine transaminase|
|Regulatory||Phosphofructokinase 2/Fructose 2,6-bisphosphatase - Bisphosphoglycerate mutase|
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