Glucose 6-phosphatase
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Glucose 6-phosphatase is an enzyme in the gluconeogenesis pathway that removes the phosphate from glucose 6-phosphate, (where the goal is to increase free glucose in the blood due to the body being in the catabolic state).
The main purpose of glucose 6-phosphatase is to dephosphorylate glucose 6-phosphate so that the free glucose can be exported from the cell via glucose transporter membrane proteins.
Locations
Glucose 6-phosphatase is found in the liver and kidney and is involved in the organs' role in glucose homeostasis. Glucose-6-phosphatase is located on the inner membrane of the endoplasmic reticulum of the liver and kidney. Muscle and brain do not contain glucose 6-phosphatase; as a result any glucose 6-phosphate produced by glycogenolysis is used to generate ATP via glycolysis.
According to Surholt and Newsholme, glucose 6-phosphatase activity IS present in a wide variety of muscles across the animal kingdom.[1]
Clinical Significance
A deficiency in glucose 6-phosphatase can lead to a glycogen storage disease called von Gierke's disease.
See also
References
- ↑ Surholt B, Newsholme E (1981). "Maximum activities and properties of glucose 6-phosphatase in muscles from vertebrates and invertebrates". Biochem J 198 (3): 621-9. PMID 6275855.
External links
Carbohydrate metabolism: glycolysis/gluconeogenesis enzymes | |
|---|---|
| Glycolysis | Glucokinase/Hexokinase/Glucose 6-phosphatase - Glucose isomerase - Phosphofructokinase 1/Fructose 1,6-bisphosphatase - Aldolase - Triosephosphate isomerase - Glyceraldehyde 3-phosphate dehydrogenase - Phosphoglycerate kinase - Phosphoglycerate mutase - Enolase - Pyruvate kinase |
| Gluconeogenesis only | Pyruvate carboxylase - Phosphoenolpyruvate carboxykinase - from lactate (Cori cycle): Lactate dehydrogenase - from alanine (Alanine cycle): Alanine transaminase |
| Regulatory | Phosphofructokinase 2/Fructose 2,6-bisphosphatase - Bisphosphoglycerate mutase |
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
