Glycerol dehydrogenase

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In enzymology, a glycerol dehydrogenase (EC 1.1.1.6) is an enzyme that catalyzes the chemical reaction

glycerol + NAD+ glycerone + NADH + H+

Thus, the two substrates of this enzyme are glycerol and NAD+, whereas its 3 products are glycerone, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is glycerol:NAD+ 2-oxidoreductase. Other names in common use include glycerin dehydrogenase, and NAD+-linked glycerol dehydrogenase. This enzyme participates in glycerolipid metabolism.

Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1JPU, 1JQ5, 1JQA, and 1TA9.

References

  • IUBMB entry for 1.1.1.6
  • BRENDA references for 1.1.1.6 (Recommended.)
  • PubMed references for 1.1.1.6
  • PubMed Central references for 1.1.1.6
  • Google Scholar references for 1.1.1.6
  • ASNIS RE, BRODIE AF (1953). "A glycerol dehydrogenase from Escherichia coli". J. Biol. Chem. 203: 153&ndash, 9. PMID 13069498.
  • Burton RM and Kaplan NO (1953). "A DPN specific glycerol dehydrogenase from Aerobacter aerogenes". J. Am. Chem. Soc. 75: 1005&ndash, 1007.
  • Lin ECC and Magasanik B (1960). "The activation of glycerol dehydrogenase from Aerobacter aerogenes by monovalent cations". J. Biol. Chem. 235: 1820&ndash, 1823.

External links

The CAS registry number for this enzyme class is 9028-14-2.

Gene Ontology (GO) codes


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