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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''YY1''' ('''Yin Yang 1''')<ref>{{cite journal | vauthors = Thiaville MM, Kim J | title = Oncogenic potential of yin yang 1 mediated through control of imprinted genes | journal = Critical Reviews in Oncogenesis | volume = 16 | issue = 3–4 | pages = 199–209 | year = 2011 | doi = 10.1615/critrevoncog.v16.i3-4.40 | pmid = 22248054 | pmc=3392609}}</ref> is a transcriptional repressor [[protein]] in humans that is encoded by the '''YY1''' [[gene]].<ref name="pmid1655281">{{cite journal | vauthors = Shi Y, Seto E, Chang LS, Shenk T | title = Transcriptional repression by YY1, a human GLI-Krüppel-related protein, and relief of repression by adenovirus E1A protein | journal = Cell | volume = 67 | issue = 2 | pages = 377–88 | date = Oct 1991 | pmid = 1655281 | pmc =  | doi = 10.1016/0092-8674(91)90189-6 }}</ref><ref name="pmid7912122">{{cite journal | vauthors = Zhu W, Lossie AC, Camper SA, Gumucio DL | title = Chromosomal localization of the transcription factor YY1 in the mouse and human | journal = Mammalian Genome | volume = 5 | issue = 4 | pages = 234–6 | date = Apr 1994 | pmid = 7912122 | pmc = | doi = 10.1007/BF00360552 }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_YY1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ubd.
| PDB = {{PDB2|1ubd}}
| Name = YY1 transcription factor
| HGNCid = 12856
| Symbol = YY1
| AltSymbols =; DELTA; NF-E1; UCRBP; YIN-YANG-1
| OMIM = 600013
| ECnumber = 
| Homologene = 2556
| MGIid = 99150
| GeneAtlas_image1 = PBB_GE_YY1_201901_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_YY1_201902_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0003714 |text = transcription corepressor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005667 |text = transcription factor complex}} {{GNF_GO|id=GO:0031519 |text = PcG protein complex}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006357 |text = regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0009952 |text = anterior/posterior pattern formation}} {{GNF_GO|id=GO:0019735 |text = antimicrobial humoral response}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7528
    | Hs_Ensembl = ENSG00000100811
    | Hs_RefseqProtein = NP_003394
    | Hs_RefseqmRNA = NM_003403
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 14
    | Hs_GenLoc_start = 99774855
    | Hs_GenLoc_end = 99814557
    | Hs_Uniprot = P25490
    | Mm_EntrezGene = 22632
    | Mm_Ensembl = ENSMUSG00000021264
    | Mm_RefseqmRNA = NM_009537
    | Mm_RefseqProtein = NP_033563
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 12
    | Mm_GenLoc_start = 109241118
    | Mm_GenLoc_end = 109264439
    | Mm_Uniprot = Q3TLF0
  }}
}}
'''YY1 transcription factor''', also known as '''YY1''', is a human [[gene]].


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. Hence, the YY in the name stands for "[[Yin and yang|yin-yang]]." YY1 may direct histone deacetylases and histone acetyltransferases to a promoter in order to activate or repress the promoter, thus implicating histone modification in the function of YY1.<ref>{{cite web | title = Entrez Gene: YY1 YY1 transcription factor| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7528| accessdate = }}</ref> YY1 promotes enhancer-promoter chromatin loops by forming dimers and promoting DNA interactions. Its disregulation disrupts enhancer-promoter loops and gene expression.<ref>{{cite journal | vauthors = Weintraub AS, Li CH, Zamudio AV, Sigova AA, Hannett NM, Day DS, Abraham BJ, Cohen MA, Nabet B, Buckley DL, Guo YE, Hnisz D, Jaenisch R, Bradner JE, Gray NS, Young RA | display-authors = 6 | title = YY1 Is a Structural Regulator of Enhancer-Promoter Loops | journal = Cell | volume = 171 | issue = 7 | pages = 1573–1588.e28 | date = December 2017 | pmid = 29224777 | doi = 10.1016/j.cell.2017.11.008 }}</ref><ref name="YY1 Haploinsufficiency Causes an Intellectual Disability Syndrome Featuring Transcriptional and Chromatin Dysfunction." />
{{PBB_Summary
| section_title =
| summary_text = YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. YY1 may direct histone deacetylases and histone acetyltransferases to a promoter in order to activate or repress the promoter, thus implicating histone modification in the function of YY1.<ref>{{cite web | title = Entrez Gene: YY1 YY1 transcription factor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7528| accessdate = }}</ref>
}}


==References==
== Clinical significance ==
{{reflist|2}}
''YY1'' heterozygous deletions, missense, and nonsense mutations cause Gabriele-DeVries syndrome (GADEVS) <ref>{{cite web | title = OMIM:GABRIELE-DE VRIES SYNDROME | url = https://www.omim.org/entry/617557| access-date = }}</ref>, an autosomal dominant neurodevelopmental disorder  characterized by intellectual disability, dysmorphic facial features, feeding problems, intrauterine growth restriction, variable cognitive impairment, behavioral problems and other congenital malformations.<ref name="YY1 Haploinsufficiency Causes an Intellectual Disability Syndrome Featuring Transcriptional and Chromatin Dysfunction.">{{cite journal | vauthors = Gabriele M, Vulto-van Silfhout AT, Germain PL, Vitriolo A, Kumar R, Douglas E, Haan E, Kosaki K, Takenouchi T, Rauch A, Steindl K, Frengen E, Misceo D, Pedurupillay CR, Stromme P, Rosenfeld JA, Shao Y, Craigen WJ, Schaaf CP, Rodriguez-Buritica D, Farach L, Friedman J, Thulin P, McLean SD, Nugent KM, Morton J, Nicholl J, Andrieux J, Stray-Pedersen A, Chambon P, Patrier S, Lynch SA, Kjaergaard S, Tørring PM, Brasch-Andersen C, Ronan A, van Haeringen A, Anderson PJ, Powis Z, Brunner HG, Pfundt R, Schuurs-Hoeijmakers JH, van Bon BW, Lelieveld S, Gilissen C, Nillesen WM, Vissers LE, Gecz J, Koolen DA, Testa G, de Vries BB | display-authors = 6 | title = YY1 Haploinsufficiency Causes an Intellectual Disability Syndrome Featuring Transcriptional and Chromatin Dysfunction | journal = American Journal of Human Genetics | volume = 100 | issue = 6 | pages = 907–925 | date = June 2017 | pmid = 28575647 | doi = 10.1016/j.ajhg.2017.05.006 }}</ref> It is available a website to share and collect clinical information between clinical doctors and families of mutated indididuals. <ref>{{cite web |title=YY1 - Collect information about clinic management and research projects |url=http://humandiseasegenes.nl/yy1/ |website=YY1}}</ref>
==Further reading==
 
{{refbegin | 2}}
 
{{PBB_Further_reading
 
| citations =
 
*{{cite journal | author=Thomas MJ, Seto E |title=Unlocking the mechanisms of transcription factor YY1: are chromatin modifying enzymes the key? |journal=Gene |volume=236 |issue= 2 |pages= 197-208 |year= 1999 |pmid= 10452940 |doi=  }}
== Interactions ==
*{{cite journal  | author=Shi Y, Seto E, Chang LS, Shenk T |title=Transcriptional repression by YY1, a human GLI-Krüppel-related protein, and relief of repression by adenovirus E1A protein. |journal=Cell |volume=67 |issue= 2 |pages= 377-88 |year= 1991 |pmid= 1655281 |doi= }}
 
*{{cite journal  | author=Park K, Atchison ML |title=Isolation of a candidate repressor/activator, NF-E1 (YY-1, delta), that binds to the immunoglobulin kappa 3' enhancer and the immunoglobulin heavy-chain mu E1 site. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 21 |pages= 9804-8 |year= 1991 |pmid= 1946405 |doi=  }}
YY1 has been shown to [[Protein-protein interaction|interact]] with:
*{{cite journal | author=Yang WM, Inouye CJ, Seto E |title=Cyclophilin A and FKBP12 interact with YY1 and alter its transcriptional activity. |journal=J. Biol. Chem. |volume=270 |issue= 25 |pages= 15187-93 |year= 1995 |pmid= 7541038 |doi=  }}
{{div col|colwidth=20em}}
*{{cite journal | author=Lee JS, Galvin KM, See RH, ''et al.'' |title=Relief of YY1 transcriptional repression by adenovirus E1A is mediated by E1A-associated protein p300. |journal=Genes Dev. |volume=9 |issue= 10 |pages= 1188-98 |year= 1995 |pmid= 7758944 |doi=  }}
* [[ATF6]],<ref name = pmid10866666>{{cite journal | vauthors = Li M, Baumeister P, Roy B, Phan T, Foti D, Luo S, Lee AS | title = ATF6 as a transcription activator of the endoplasmic reticulum stress element: thapsigargin stress-induced changes and synergistic interactions with NF-Y and YY1 | journal = Molecular and Cellular Biology | volume = 20 | issue = 14 | pages = 5096–106 | date = Jul 2000 | pmid = 10866666 | pmc = 85959 | doi =  10.1128/mcb.20.14.5096-5106.2000}}</ref>
*{{cite journal | author=Zhou Q, Gedrich RW, Engel DA |title=Transcriptional repression of the c-fos gene by YY1 is mediated by a direct interaction with ATF/CREB. |journal=J. Virol. |volume=69 |issue= 7 |pages= 4323-30 |year= 1995 |pmid= 7769693 |doi= }}
* [[EP300]],<ref name = pmid11486036/><ref name = pmid7758944>{{cite journal | vauthors = Lee JS, Galvin KM, See RH, Eckner R, Livingston D, Moran E, Shi Y | title = Relief of YY1 transcriptional repression by adenovirus E1A is mediated by E1A-associated protein p300 | journal = Genes & Development | volume = 9 | issue = 10 | pages = 1188–98 | date = May 1995 | pmid = 7758944 | doi =  10.1101/gad.9.10.1188}}</ref>
*{{cite journal | author=Zhu W, Lossie AC, Camper SA, Gumucio DL |title=Chromosomal localization of the transcription factor YY1 in the mouse and human. |journal=Mamm. Genome |volume=5 |issue= 4 |pages= 234-6 |year= 1994 |pmid= 7912122 |doi=  }}
* [[FKBP3]],<ref name = pmid11532945>{{cite journal | vauthors = Yang WM, Yao YL, Seto E | title = The FK506-binding protein 25 functionally associates with histone deacetylases and with transcription factor YY1 | journal = The EMBO Journal | volume = 20 | issue = 17 | pages = 4814–25 | date = Sep 2001 | pmid = 11532945 | pmc = 125595 | doi = 10.1093/emboj/20.17.4814 }}</ref>
*{{cite journal | author=Shrivastava A, Saleque S, Kalpana GV, ''et al.'' |title=Inhibition of transcriptional regulator Yin-Yang-1 by association with c-Myc. |journal=Science |volume=262 |issue= 5141 |pages= 1889-92 |year= 1994 |pmid= 8266081 |doi=  }}
* [[HDAC3]],<ref name = pmid11486036/><ref name = pmid9346952/>
*{{cite journal | author=Becker KG, Swergold GD, Ozato K, Thayer RE |title=Binding of the ubiquitous nuclear transcription factor YY1 to a cis regulatory sequence in the human LINE-1 transposable element. |journal=Hum. Mol. Genet. |volume=2 |issue= 10 |pages= 1697-702 |year= 1994 |pmid= 8268924 |doi=  }}
* [[Histone deacetylase 2]],<ref name = pmid11486036>{{cite journal | vauthors = Yao YL, Yang WM, Seto E | title = Regulation of transcription factor YY1 by acetylation and deacetylation | journal = Molecular and Cellular Biology | volume = 21 | issue = 17 | pages = 5979–91 | date = Sep 2001 | pmid = 11486036 | pmc = 87316 | doi =  10.1128/mcb.21.17.5979-5991.2001}}</ref><ref name = pmid9346952>{{cite journal | vauthors = Yang WM, Yao YL, Sun JM, Davie JR, Seto E | title = Isolation and characterization of cDNAs corresponding to an additional member of the human histone deacetylase gene family | journal = The Journal of Biological Chemistry | volume = 272 | issue = 44 | pages = 28001–7 | date = Oct 1997 | pmid = 9346952 | doi =  10.1074/jbc.272.44.28001}}</ref><ref name = pmid9016636>{{cite journal | vauthors = Kalenik JL, Chen D, Bradley ME, Chen SJ, Lee TC | title = Yeast two-hybrid cloning of a novel zinc finger protein that interacts with the multifunctional transcription factor YY1 | journal = Nucleic Acids Research | volume = 25 | issue = 4 | pages = 843–9 | date = Feb 1997 | pmid = 9016636 | pmc = 146511 | doi =  10.1093/nar/25.4.843}}</ref>
*{{cite journal | author=Margolis DM, Somasundaran M, Green MR |title=Human transcription factor YY1 represses human immunodeficiency virus type 1 transcription and virion production. |journal=J. Virol. |volume=68 |issue= 2 |pages= 905-10 |year= 1994 |pmid= 8289393 |doi=  }}
* [[Myc]],<ref name = pmid8266081>{{cite journal | vauthors = Shrivastava A, Saleque S, Kalpana GV, Artandi S, Goff SP, Calame K | title = Inhibition of transcriptional regulator Yin-Yang-1 by association with c-Myc | journal = Science | volume = 262 | issue = 5141 | pages = 1889–92 | date = Dec 1993 | pmid = 8266081 | doi =  10.1126/science.8266081}}</ref>
*{{cite journal | author=Lee JS, Galvin KM, Shi Y |title=Evidence for physical interaction between the zinc-finger transcription factors YY1 and Sp1. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 13 |pages= 6145-9 |year= 1993 |pmid= 8327494 |doi= }}
* [[NOTCH1]],<ref name = pmid12913000>{{cite journal | vauthors = Yeh TS, Lin YM, Hsieh RH, Tseng MJ | title = Association of transcription factor YY1 with the high molecular weight Notch complex suppresses the transactivation activity of Notch | journal = The Journal of Biological Chemistry | volume = 278 | issue = 43 | pages = 41963–9 | date = Oct 2003 | pmid = 12913000 | doi = 10.1074/jbc.M304353200 }}</ref>
*{{cite journal | author=Yang WM, Inouye C, Zeng Y, ''et al.'' |title=Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 23 |pages= 12845-50 |year= 1996 |pmid= 8917507 |doi= }}
* [[RYBP]],<ref name = pmid10369680>{{cite journal | vauthors = García E, Marcos-Gutiérrez C, del Mar Lorente M, Moreno JC, Vidal M | title = RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1 | journal = The EMBO Journal | volume = 18 | issue = 12 | pages = 3404–18 | date = Jun 1999 | pmid = 10369680 | pmc = 1171420 | doi = 10.1093/emboj/18.12.3404 }}</ref> and
*{{cite journal | author=Houbaviy HB, Usheva A, Shenk T, Burley SK |title=Cocrystal structure of YY1 bound to the adeno-associated virus P5 initiator. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 24 |pages= 13577-82 |year= 1997 |pmid= 8942976 |doi=  }}
* [[SAP30]].<ref name = huang>{{cite journal | vauthors = Huang NE, Lin CH, Lin YS, Yu WC | title = Modulation of YY1 activity by SAP30 | journal = Biochemical and Biophysical Research Communications | volume = 306 | issue = 1 | pages = 267–75 | date = Jun 2003 | pmid = 12788099 | doi =  10.1016/s0006-291x(03)00966-5}}</ref>
*{{cite journal | author=Kalenik JL, Chen D, Bradley ME, ''et al.'' |title=Yeast two-hybrid cloning of a novel zinc finger protein that interacts with the multifunctional transcription factor YY1. |journal=Nucleic Acids Res. |volume=25 |issue= 4 |pages= 843-9 |year= 1997 |pmid= 9016636 |doi=  }}
* [[Seryl-tRNA Synthetase]].<ref name = fu>{{cite journal | vauthors = Fu CY, Wang P, Tsai HJ, | title = Competitive binding between Seryl-tRNA synthetase/YY1 complex and NFKB1 at the distal segment results in differential regulation of human vegfa promoter activity during angiogenesis | journal = Nucleic Acids Research | volume = 45 | issue = 5 | pages = 2423–2437 | date = Nov 2017 | doi =  10.1093/nar/gkw1187}}</ref> {{Div col end}}
*{{cite journal  | author=Cole EG, Gaston K |title=A functional YY1 binding site is necessary and sufficient to activate Surf-1 promoter activity in response to serum growth factors. |journal=Nucleic Acids Res. |volume=25 |issue= 18 |pages= 3705-11 |year= 1997 |pmid= 9278494 |doi=  }}
 
*{{cite journal | author=Yang WM, Yao YL, Sun JM, ''et al.'' |title=Isolation and characterization of cDNAs corresponding to an additional member of the human histone deacetylase gene family. |journal=J. Biol. Chem. |volume=272 |issue= 44 |pages= 28001-7 |year= 1997 |pmid= 9346952 |doi= }}
== References ==
*{{cite journal | author=Romerio F, Gabriel MN, Margolis DM |title=Repression of human immunodeficiency virus type 1 through the novel cooperation of human factors YY1 and LSF. |journal=J. Virol. |volume=71 |issue= 12 |pages= 9375-82 |year= 1997 |pmid= 9371597 |doi= }}
{{Reflist}}
*{{cite journal | author=McNeil S, Guo B, Stein JL, ''et al.'' |title=Targeting of the YY1 transcription factor to the nucleolus and the nuclear matrix in situ: the C-terminus is a principal determinant for nuclear trafficking. |journal=J. Cell. Biochem. |volume=68 |issue= 4 |pages= 500-10 |year= 1998 |pmid= 9493912 |doi= }}
 
*{{cite journal | author=Viles JH, Patel SU, Mitchell JB, ''et al.'' |title=Design, synthesis and structure of a zinc finger with an artificial beta-turn. |journal=J. Mol. Biol. |volume=279 |issue= 4 |pages= 973-86 |year= 1998 |pmid= 9642075 |doi= 10.1006/jmbi.1998.1764 }}
== Further reading ==
*{{cite journal | author=Yao YL, Dupont BR, Ghosh S, ''et al.'' |title=Cloning, chromosomal localization and promoter analysis of the human transcription factor YY1. |journal=Nucleic Acids Res. |volume=26 |issue= 16 |pages= 3776-83 |year= 1998 |pmid= 9685495 |doi=  }}
{{Refbegin | 2}}
}}
* {{cite journal | vauthors = Thomas MJ, Seto E | title = Unlocking the mechanisms of transcription factor YY1: are chromatin modifying enzymes the key? | journal = Gene | volume = 236 | issue = 2 | pages = 197–208 | date = Aug 1999 | pmid = 10452940 | doi = 10.1016/S0378-1119(99)00261-9 }}
{{refend}}
* {{cite journal | vauthors = Park K, Atchison ML | title = Isolation of a candidate repressor/activator, NF-E1 (YY-1, delta), that binds to the immunoglobulin kappa 3' enhancer and the immunoglobulin heavy-chain mu E1 site | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 88 | issue = 21 | pages = 9804–8 | date = Nov 1991 | pmid = 1946405 | pmc = 52809 | doi = 10.1073/pnas.88.21.9804 }}
* {{cite journal | vauthors = Yang WM, Inouye CJ, Seto E | title = Cyclophilin A and FKBP12 interact with YY1 and alter its transcriptional activity | journal = The Journal of Biological Chemistry | volume = 270 | issue = 25 | pages = 15187–93 | date = Jun 1995 | pmid = 7541038 | doi = 10.1074/jbc.270.25.15187 }}
* {{cite journal | vauthors = Lee JS, Galvin KM, See RH, Eckner R, Livingston D, Moran E, Shi Y | title = Relief of YY1 transcriptional repression by adenovirus E1A is mediated by E1A-associated protein p300 | journal = Genes & Development | volume = 9 | issue = 10 | pages = 1188–98 | date = May 1995 | pmid = 7758944 | doi = 10.1101/gad.9.10.1188 }}
* {{cite journal | vauthors = Zhou Q, Gedrich RW, Engel DA | title = Transcriptional repression of the c-fos gene by YY1 is mediated by a direct interaction with ATF/CREB | journal = Journal of Virology | volume = 69 | issue = 7 | pages = 4323–30 | date = Jul 1995 | pmid = 7769693 | pmc = 189172 | doi =  }}
* {{cite journal | vauthors = Shrivastava A, Saleque S, Kalpana GV, Artandi S, Goff SP, Calame K | title = Inhibition of transcriptional regulator Yin-Yang-1 by association with c-Myc | journal = Science | volume = 262 | issue = 5141 | pages = 1889–92 | date = Dec 1993 | pmid = 8266081 | doi = 10.1126/science.8266081 }}
* {{cite journal | vauthors = Becker KG, Swergold GD, Ozato K, Thayer RE | title = Binding of the ubiquitous nuclear transcription factor YY1 to a cis regulatory sequence in the human LINE-1 transposable element | journal = Human Molecular Genetics | volume = 2 | issue = 10 | pages = 1697–702 | date = Oct 1993 | pmid = 8268924 | doi = 10.1093/hmg/2.10.1697 }}
* {{cite journal | vauthors = Margolis DM, Somasundaran M, Green MR | title = Human transcription factor YY1 represses human immunodeficiency virus type 1 transcription and virion production | journal = Journal of Virology | volume = 68 | issue = 2 | pages = 905–10 | date = Feb 1994 | pmid = 8289393 | pmc = 236527 | doi =  }}
* {{cite journal | vauthors = Lee JS, Galvin KM, Shi Y | title = Evidence for physical interaction between the zinc-finger transcription factors YY1 and Sp1 | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 90 | issue = 13 | pages = 6145–9 | date = Jul 1993 | pmid = 8327494 | pmc = 46884 | doi = 10.1073/pnas.90.13.6145 }}
* {{cite journal | vauthors = Yang WM, Inouye C, Zeng Y, Bearss D, Seto E | title = Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3 | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 93 | issue = 23 | pages = 12845–50 | date = Nov 1996 | pmid = 8917507 | pmc = 24008 | doi = 10.1073/pnas.93.23.12845 }}
* {{cite journal | vauthors = Houbaviy HB, Usheva A, Shenk T, Burley SK | title = Cocrystal structure of YY1 bound to the adeno-associated virus P5 initiator | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 93 | issue = 24 | pages = 13577–82 | date = Nov 1996 | pmid = 8942976 | pmc = 19349 | doi = 10.1073/pnas.93.24.13577 }}
* {{cite journal | vauthors = Kalenik JL, Chen D, Bradley ME, Chen SJ, Lee TC | title = Yeast two-hybrid cloning of a novel zinc finger protein that interacts with the multifunctional transcription factor YY1 | journal = Nucleic Acids Research | volume = 25 | issue = 4 | pages = 843–9 | date = Feb 1997 | pmid = 9016636 | pmc = 146511 | doi = 10.1093/nar/25.4.843 }}
* {{cite journal | vauthors = Cole EG, Gaston K | title = A functional YY1 binding site is necessary and sufficient to activate Surf-1 promoter activity in response to serum growth factors | journal = Nucleic Acids Research | volume = 25 | issue = 18 | pages = 3705–11 | date = Sep 1997 | pmid = 9278494 | pmc = 146936 | doi = 10.1093/nar/25.18.3705 }}
* {{cite journal | vauthors = Yang WM, Yao YL, Sun JM, Davie JR, Seto E | title = Isolation and characterization of cDNAs corresponding to an additional member of the human histone deacetylase gene family | journal = The Journal of Biological Chemistry | volume = 272 | issue = 44 | pages = 28001–7 | date = Oct 1997 | pmid = 9346952 | doi = 10.1074/jbc.272.44.28001 }}
* {{cite journal | vauthors = Romerio F, Gabriel MN, Margolis DM | title = Repression of human immunodeficiency virus type 1 through the novel cooperation of human factors YY1 and LSF | journal = Journal of Virology | volume = 71 | issue = 12 | pages = 9375–82 | date = Dec 1997 | pmid = 9371597 | pmc = 230241 | doi =  }}
* {{cite journal | vauthors = McNeil S, Guo B, Stein JL, Lian JB, Bushmeyer S, Seto E, Atchison ML, Penman S, van Wijnen AJ, Stein GS | title = Targeting of the YY1 transcription factor to the nucleolus and the nuclear matrix in situ: the C-terminus is a principal determinant for nuclear trafficking | journal = Journal of Cellular Biochemistry | volume = 68 | issue = 4 | pages = 500–10 | date = Mar 1998 | pmid = 9493912 | doi = 10.1002/(SICI)1097-4644(19980315)68:4<500::AID-JCB9>3.0.CO;2-U }}
* {{cite journal | vauthors = Viles JH, Patel SU, Mitchell JB, Moody CM, Justice DE, Uppenbrink J, Doyle PM, Harris CJ, Sadler PJ, Thornton JM | title = Design, synthesis and structure of a zinc finger with an artificial beta-turn | journal = Journal of Molecular Biology | volume = 279 | issue = 4 | pages = 973–86 | date = Jun 1998 | pmid = 9642075 | doi = 10.1006/jmbi.1998.1764 }}
* {{cite journal | vauthors = Yao YL, Dupont BR, Ghosh S, Fang Y, Leach RJ, Seto E | title = Cloning, chromosomal localization and promoter analysis of the human transcription factor YY1 | journal = Nucleic Acids Research | volume = 26 | issue = 16 | pages = 3776–83 | date = Aug 1998 | pmid = 9685495 | pmc = 147783 | doi = 10.1093/nar/26.16.3776 }}
{{Refend}}
 
== External links ==
* {{FactorBook|YY1}}
{{PDB Gallery|geneid=7528}}
{{Use dmy dates|date=March 2012}}
 
{{Transcription factors|g2}}


[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{Transcription factors}}
{{protein-stub}}
{{WikiDoc Sources}}

Latest revision as of 06:26, 10 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
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Ensembl

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RefSeq (mRNA)

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RefSeq (protein)

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YY1 (Yin Yang 1)[1] is a transcriptional repressor protein in humans that is encoded by the YY1 gene.[2][3]

Function

YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. Hence, the YY in the name stands for "yin-yang." YY1 may direct histone deacetylases and histone acetyltransferases to a promoter in order to activate or repress the promoter, thus implicating histone modification in the function of YY1.[4] YY1 promotes enhancer-promoter chromatin loops by forming dimers and promoting DNA interactions. Its disregulation disrupts enhancer-promoter loops and gene expression.[5][6]

Clinical significance

YY1 heterozygous deletions, missense, and nonsense mutations cause Gabriele-DeVries syndrome (GADEVS) [7], an autosomal dominant neurodevelopmental disorder characterized by intellectual disability, dysmorphic facial features, feeding problems, intrauterine growth restriction, variable cognitive impairment, behavioral problems and other congenital malformations.[6] It is available a website to share and collect clinical information between clinical doctors and families of mutated indididuals. [8]



Interactions

YY1 has been shown to interact with:

References

  1. ↑ Thiaville MM, Kim J (2011). "Oncogenic potential of yin yang 1 mediated through control of imprinted genes". Critical Reviews in Oncogenesis. 16 (3–4): 199–209. doi:10.1615/critrevoncog.v16.i3-4.40. PMC 3392609. PMID 22248054.
  2. ↑ Shi Y, Seto E, Chang LS, Shenk T (Oct 1991). "Transcriptional repression by YY1, a human GLI-Krüppel-related protein, and relief of repression by adenovirus E1A protein". Cell. 67 (2): 377–88. doi:10.1016/0092-8674(91)90189-6. PMID 1655281.
  3. ↑ Zhu W, Lossie AC, Camper SA, Gumucio DL (Apr 1994). "Chromosomal localization of the transcription factor YY1 in the mouse and human". Mammalian Genome. 5 (4): 234–6. doi:10.1007/BF00360552. PMID 7912122.
  4. ↑ "Entrez Gene: YY1 YY1 transcription factor".
  5. ↑ Weintraub AS, Li CH, Zamudio AV, Sigova AA, Hannett NM, Day DS, et al. (December 2017). "YY1 Is a Structural Regulator of Enhancer-Promoter Loops". Cell. 171 (7): 1573–1588.e28. doi:10.1016/j.cell.2017.11.008. PMID 29224777.
  6. ↑ 6.0 6.1 Gabriele M, Vulto-van Silfhout AT, Germain PL, Vitriolo A, Kumar R, Douglas E, et al. (June 2017). "YY1 Haploinsufficiency Causes an Intellectual Disability Syndrome Featuring Transcriptional and Chromatin Dysfunction". American Journal of Human Genetics. 100 (6): 907–925. doi:10.1016/j.ajhg.2017.05.006. PMID 28575647.
  7. ↑ "OMIM:GABRIELE-DE VRIES SYNDROME".
  8. ↑ "YY1 - Collect information about clinic management and research projects". YY1.
  9. ↑ Li M, Baumeister P, Roy B, Phan T, Foti D, Luo S, Lee AS (Jul 2000). "ATF6 as a transcription activator of the endoplasmic reticulum stress element: thapsigargin stress-induced changes and synergistic interactions with NF-Y and YY1". Molecular and Cellular Biology. 20 (14): 5096–106. doi:10.1128/mcb.20.14.5096-5106.2000. PMC 85959. PMID 10866666.
  10. ↑ 10.0 10.1 10.2 Yao YL, Yang WM, Seto E (Sep 2001). "Regulation of transcription factor YY1 by acetylation and deacetylation". Molecular and Cellular Biology. 21 (17): 5979–91. doi:10.1128/mcb.21.17.5979-5991.2001. PMC 87316. PMID 11486036.
  11. ↑ Lee JS, Galvin KM, See RH, Eckner R, Livingston D, Moran E, Shi Y (May 1995). "Relief of YY1 transcriptional repression by adenovirus E1A is mediated by E1A-associated protein p300". Genes & Development. 9 (10): 1188–98. doi:10.1101/gad.9.10.1188. PMID 7758944.
  12. ↑ Yang WM, Yao YL, Seto E (Sep 2001). "The FK506-binding protein 25 functionally associates with histone deacetylases and with transcription factor YY1". The EMBO Journal. 20 (17): 4814–25. doi:10.1093/emboj/20.17.4814. PMC 125595. PMID 11532945.
  13. ↑ 13.0 13.1 Yang WM, Yao YL, Sun JM, Davie JR, Seto E (Oct 1997). "Isolation and characterization of cDNAs corresponding to an additional member of the human histone deacetylase gene family". The Journal of Biological Chemistry. 272 (44): 28001–7. doi:10.1074/jbc.272.44.28001. PMID 9346952.
  14. ↑ Kalenik JL, Chen D, Bradley ME, Chen SJ, Lee TC (Feb 1997). "Yeast two-hybrid cloning of a novel zinc finger protein that interacts with the multifunctional transcription factor YY1". Nucleic Acids Research. 25 (4): 843–9. doi:10.1093/nar/25.4.843. PMC 146511. PMID 9016636.
  15. ↑ Shrivastava A, Saleque S, Kalpana GV, Artandi S, Goff SP, Calame K (Dec 1993). "Inhibition of transcriptional regulator Yin-Yang-1 by association with c-Myc". Science. 262 (5141): 1889–92. doi:10.1126/science.8266081. PMID 8266081.
  16. ↑ Yeh TS, Lin YM, Hsieh RH, Tseng MJ (Oct 2003). "Association of transcription factor YY1 with the high molecular weight Notch complex suppresses the transactivation activity of Notch". The Journal of Biological Chemistry. 278 (43): 41963–9. doi:10.1074/jbc.M304353200. PMID 12913000.
  17. ↑ García E, Marcos-Gutiérrez C, del Mar Lorente M, Moreno JC, Vidal M (Jun 1999). "RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1". The EMBO Journal. 18 (12): 3404–18. doi:10.1093/emboj/18.12.3404. PMC 1171420. PMID 10369680.
  18. ↑ Huang NE, Lin CH, Lin YS, Yu WC (Jun 2003). "Modulation of YY1 activity by SAP30". Biochemical and Biophysical Research Communications. 306 (1): 267–75. doi:10.1016/s0006-291x(03)00966-5. PMID 12788099.
  19. ↑ Fu CY, Wang P, Tsai HJ (Nov 2017). "Competitive binding between Seryl-tRNA synthetase/YY1 complex and NFKB1 at the distal segment results in differential regulation of human vegfa promoter activity during angiogenesis". Nucleic Acids Research. 45 (5): 2423–2437. doi:10.1093/nar/gkw1187.

Further reading

External links

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