Verteporfin

Verteporfin

File:Verteporfin.svg
Clinical data
Routes of administration	Intravenous
ATC code	L01XD02 (WHO)
Identifiers
CAS Number	129497-78-5
PubChem CID	5362420
DrugBank	APRD01290
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C41H42N4O8
Molar mass	718.794 g/mol

Verteporfin, otherwise known as benzoporphyrin derivative (trade name Visudyne®), is a medication used as a photosensitizer for photodynamic therapy to eliminate the abnormal blood vessels in the eye associated with conditions such as the wet form of macular degeneration. Verteporfin accumulates in these abnormal blood vessels and, when stimulated by nonthermal red light with a wavelength of 693 nm in the presence of oxygen, produces highly reactive short-lived singlet oxygen and other reactive oxygen radicals, resulting in local damage to the endothelium and blockage of the vessels.

Administration

Verteporfin is given intravenously, within 15 minutes before laser treatment.

Side effects

Most commonly, blurred vision. Also, photosensitivity; it is advised to avoid exposure to sunlight and unscreened lighting until 48 hours after the injection of verteporfin.

External links

• Visudyne® information

Template:Pharma-stub

Template:WikiDoc Sources